María Albertina Romaniuk
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View article: THE PROTECTIVE POWER OF PHYSICAL ACTIVITY: INSIGHTS INTO COLON POLYPS AND COLORECTAL CANCER
THE PROTECTIVE POWER OF PHYSICAL ACTIVITY: INSIGHTS INTO COLON POLYPS AND COLORECTAL CANCER Open
Background: Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide. Regular physical activity (PA) is increasingly recognized as a modifiable factor influencing both cancer prevention and patient outcomes. This re…
View article: EXPLORING THE THERAPEUTIC POTENTIAL OF FECAL MICROBIOTA TRANSPLANTATION IN INFLAMMATORY BOWEL DISEASE
EXPLORING THE THERAPEUTIC POTENTIAL OF FECAL MICROBIOTA TRANSPLANTATION IN INFLAMMATORY BOWEL DISEASE Open
Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic, relapsing inflammatory disorder of the gastrointestinal tract associated with dysbiosis of the gut microbiota. Fecal mi…
View article: Extracellular vesicles and chronic inflammation during HIV infection
Extracellular vesicles and chronic inflammation during HIV infection Open
Inflammation is a hallmark of HIV infection. Among the multiple stimuli that can induce inflammation in untreated infection, ongoing viral replication is a primary driver. After initiation of effective combined antiretroviral therapy (cART…
View article: The RNA-binding protein TcUBP1 up-regulates an RNA regulon for a cell surface–associated Trypanosoma cruzi glycoprotein and promotes parasite infectivity
The RNA-binding protein TcUBP1 up-regulates an RNA regulon for a cell surface–associated Trypanosoma cruzi glycoprotein and promotes parasite infectivity Open
The regulation of transcription in trypanosomes is unusual. To modulate protein synthesis during their complex developmental stages, these unicellular microorganisms rely largely on post-transcriptional gene expression pathways. These path…
Translational repression by an RNA-binding protein promotes differentiation to infective forms in Trypanosoma cruzi Open
View article: Regulation of RNA binding proteins in trypanosomatid protozoan parasites
Regulation of RNA binding proteins in trypanosomatid protozoan parasites Open
Posttranscriptional mechanisms have a critical role in the overall outcome of gene expression. These mechanisms are especially relevant in protozoa from the genus Trypanosoma, which is composed by death threatening parasites affecting peop…
View article: Association of <scp>UBP</scp>1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional <scp>P</scp>32 protein
Association of <span>UBP</span>1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional <span>P</span>32 protein Open
Summary Regulation of gene expression in trypanosomatid parasitic protozoa is mainly achieved posttranscriptionally. RNA ‐binding proteins ( RBPs ) associate to 3′ untranslated regions in m RNA s through dedicated domains such as the RNA r…