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View article: Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli
Late Clinical Outcomes of Balloon-Expandable Valves in Small Annuli Open
Five-year clinical outcomes were excellent and comparable between patients with small vs large aortic annuli. Outcomes in patients with small annuli were not affected by 30-day MG or PPM.
View article: A Randomized Trial of Cardiac Catheterization With Fasting Versus Liberal Oral Intake: The CALORI Trial
A Randomized Trial of Cardiac Catheterization With Fasting Versus Liberal Oral Intake: The CALORI Trial Open
In this single-center randomized trial, a liberal nonfasting strategy prior to cardiac catheterization significantly improved patient well-being and satisfaction without compromising safety. Given the findings of this and other studies, ro…
View article: Contemporary Review of the Methods for Rapid Ventricular Pacing During Transcatheter Aortic Valve Replacement
Contemporary Review of the Methods for Rapid Ventricular Pacing During Transcatheter Aortic Valve Replacement Open
Transcatheter aortic valve replacement (TAVR) is a widely accepted treatment strategy for patients with severe aortic stenosis across all risk profiles. Pacing stimulation of the right ventricle (RV) is the conventional method used during …
View article: LB-4 | Cardiac Catheterization with Liberal Oral Intake: The CALORI trial
LB-4 | Cardiac Catheterization with Liberal Oral Intake: The CALORI trial Open
Routine pre-procedural fasting before cardiac catheterization remains standard of care, despite a lack of robust evidence to support this practice. We investigated the impact of a liberal non-fasting strategy versus standardized nil per os…
View article: Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints Open
Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR …
View article: Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints Open
Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR …
View article: Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints Open
Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR …
View article: Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial
Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial Open
Background Left ventricular (LV) global longitudinal strain (GLS) provides incremental prognostic information over LV ejection fraction in patients with heart failure (HF) and secondary mitral regurgitation. We examined the prognostic impa…
View article: Severity of and Recovery From Anemia After Transcatheter Aortic Valve Replacement: An Analysis of the PARTNER Trials and Registries
Severity of and Recovery From Anemia After Transcatheter Aortic Valve Replacement: An Analysis of the PARTNER Trials and Registries Open
In patients undergoing TAVR, moderate-to-severe anemia is independently associated with increased 1-year mortality, and recovery from anemia after TAVR is associated with favorable outcomes. Further efforts are needed to determine whether …
View article: Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes
Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes Open
In patients with severe aortic stenosis and LVEF less than 50%, 1 in 3 experience LVEF improvement within 1 month after TAVR. Early LVEF improvement is associated with lower 5-year all-cause and cardiac death.
View article: Minimum Core Data Elements for Evaluation of TAVR
Minimum Core Data Elements for Evaluation of TAVR Open
Transcatheter aortic valve replacement (TAVR) is the standard of care for severe, symptomatic aortic stenosis. Real-world TAVR data collection contributes to benefit/risk assessment and safety evidence for the U.S. Food and Drug Administra…
View article: Impact of Flow on Prosthesis-Patient Mismatch Following Transcatheter and Surgical Aortic Valve Replacement
Impact of Flow on Prosthesis-Patient Mismatch Following Transcatheter and Surgical Aortic Valve Replacement Open
Background: Severe prosthesis-patient mismatch (PPM) is diagnosed by an indexed effective orifice area <0.65 cm 2 /m 2 , which is derived from stroke volume index. We examined the impact of flow, determined by stroke volume index, on sever…
View article: Postoperative Atrial Fibrillation or Flutter Following Transcatheter or Surgical Aortic Valve Replacement
Postoperative Atrial Fibrillation or Flutter Following Transcatheter or Surgical Aortic Valve Replacement Open
In the PARTNER 3 trial, early POAF was more frequent following SAVR compared with TAVR. Late POAF, but not early POAF, was significantly associated with worse outcomes at 2 years, irrespective of treatment modality.
View article: Prosthesis-Patient Mismatch After Aortic Valve Replacement in the PARTNER 2 Trial and Registry
Prosthesis-Patient Mismatch After Aortic Valve Replacement in the PARTNER 2 Trial and Registry Open
EOAi measured by echocardiography results in a higher incidence of PPM following SAVR or TAVR than PPM based on predicted EOAi. Severe PPMP is rare (<1.5%), but is associated with increased all-cause death and rehospitalization after SAVR,…
View article: Impact of Predilation During Transcatheter Aortic Valve Replacement: Insights From the PARTNER 3 Trial
Impact of Predilation During Transcatheter Aortic Valve Replacement: Insights From the PARTNER 3 Trial Open
Background: The use of predilation during transcatheter aortic valve replacement (TAVR) is variable, and its association with outcomes remains unknown. We evaluated the impact of predilation versus no predilation (direct TAVR) in the low-r…
View article: Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research
Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research Open
Acknowledging the dynamic and evolving nature of less-invasive aortic valve therapies, further refinements of clinical research processes are required. The adoption of these updated and newly proposed VARC-3 endpoints and definitions will …
View article: A neural system dynamics modeling platform and its applications in randomized controlled trial data analysis
A neural system dynamics modeling platform and its applications in randomized controlled trial data analysis Open
Background: Conventional statistical methods used in clinical trials lack the ability to predict patient specific risk and very often do not consider the effects of time varying interventions. The aim of this study is to test a novel artif…
View article: Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research
Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research Open
Aims The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trial…
View article: Association of Natriuretic Peptide Levels After Transcatheter Aortic Valve Replacement With Subsequent Clinical Outcomes
Association of Natriuretic Peptide Levels After Transcatheter Aortic Valve Replacement With Subsequent Clinical Outcomes Open
Elevated BNP levels after TAVR was independently associated with increased subsequent mortality and rehospitalizations. Further studies to determine how best to mitigate this risk are warranted.
View article: Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement
Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement Open
Background: Although aortic valve replacement is associated with a major benefit in high-gradient (HG) severe aortic stenosis (AS), the results in low-gradient (LG, mean gradient <40 mm Hg) AS are conflicting. LG severe AS may be subdivide…