María Ángeles Espinosa
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View article: MON-829 Sex-Specific Cardiometabolic Benefits of Tirzepatide: A Real-World Study on ASCVD Risk Mitigation
MON-829 Sex-Specific Cardiometabolic Benefits of Tirzepatide: A Real-World Study on ASCVD Risk Mitigation Open
Disclosure: R.D. Rivera Gutierrez: None. D. Bechenati: None. R. Castaneda: None. M.A. Espinosa: None. J.L. Villamarin: None. E. Tama: None. J.L. Meek: None. T.M. Taaffe: None. P.K. Bennett: None. A.J. Acosta: Novo Nordisk, Gila Therapeutic…
View article: SAT-688 One-Year Real-World Weight Loss Outcomes with Tirzepatide in Postmenopausal Women with and without Hormone Therapy
SAT-688 One-Year Real-World Weight Loss Outcomes with Tirzepatide in Postmenopausal Women with and without Hormone Therapy Open
Disclosure: D. Bechenati: None. R. Castaneda: None. R.D. Rivera Gutierrez: None. M.A. Espinosa: None. J.L. Villamarin: None. E. Tama: None. J.L. Meek: None. S. Faubion: Era Women’s Health Platform, PriMed, AiCME, MedAll, Medscape, Weight W…
View article: MON-720 Beyond Age: Sex as the Key Weight Loss Predictor with Tirzepatide
MON-720 Beyond Age: Sex as the Key Weight Loss Predictor with Tirzepatide Open
Disclosure: R. Castaneda: None. D. Bechenati: None. R.D. Rivera Gutierrez: None. M.A. Espinosa: None. J.L. Villamarin: None. E. Tama: None. J.L. Meek: None. P. Bennett: None. A. Acosta: Novo Nordisk, Gila Therapeutics, Amgen Inc, Regeneron…
View article: Rare Genetic Variants in Young Adults Requiring Pacemaker Implantation
Rare Genetic Variants in Young Adults Requiring Pacemaker Implantation Open
Unrecognized rare genetic variants increase the risk of CCD in young adults with CCD of unknown etiology. Genetic testing should be performed in patients age ≤60 years with CCD of unknown etiology. The role of genetic variants in sarcomeri…
View article: Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy Open
Patients with nonischemic dilated cardiomyopathy (NIDCM) are at higher risk of stroke than their age-matched population. However, the risk of bleeding neutralizes the benefit of preventive oral anticoagulation. In this work, we show that i…
View article: Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives
Penetrance of Dilated Cardiomyopathy in Genotype-Positive Relatives Open
View article: Cardiac Stasis Imaging, Stroke and Silent Brain Infarcts in Patients with Non-Ischemic Dilated Cardiomyopathy
Cardiac Stasis Imaging, Stroke and Silent Brain Infarcts in Patients with Non-Ischemic Dilated Cardiomyopathy Open
Background Cardioembolic stroke is one of the most devastating complications of non-ischemic dilated cardiomyopathy (NIDCM). However, in clinical trials of primary prevention, the benefits of anticoagulation were hampered by the risk of bl…
View article: Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction
Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction Open
BACKGROUND: Twitch-independent tension has been demonstrated in cardiomyocytes, but its role in heart failure (HF) is unclear. We aimed to address twitch-independent tension as a source of diastolic dysfunction by isolating the effects of …
View article: Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation
Late gadolinium enhancement distribution patterns in non-ischaemic dilated cardiomyopathy: genotype–phenotype correlation Open
Aims Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM); there is little information about its frequency and distribution pattern according to the underlying genetic substrate. We sought to …
View article: Phenotype and clinical outcomes of Glu89Lys hereditary transthyretin amyloidosis: a new endemic variant in Spain
Phenotype and clinical outcomes of Glu89Lys hereditary transthyretin amyloidosis: a new endemic variant in Spain Open
Background
\nThe p.Glu109Lys variant (Glu89Lys) is a rare cause of hereditary transthyretin amyloidosis (ATTRv) for which clinical spectrum remains unresolved. We sought to describe the clinical characteristics and outcomes of ATTR Glu89Ly…
View article: Exercise unmasks impaired vascular and cardiac hemodynamic in patients with hypertrophic cardiomyopathy
Exercise unmasks impaired vascular and cardiac hemodynamic in patients with hypertrophic cardiomyopathy Open
Background/Introduction Exertional dyspnea is a common finding in patients with Hypertrophic Cardiomyopathy (HCM), yet little data is available regarding the hemodynamic disturbances that lead to symptom development in this population. Pur…
View article: Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy
Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy Open
View article: Natural History of MYH7-Related Dilated Cardiomyopathy
Natural History of MYH7-Related Dilated Cardiomyopathy Open
View article: Evidence-based Standards in the Design of Family Support Programmes in Spain
Evidence-based Standards in the Design of Family Support Programmes in Spain Open
The positive parenting approach has highlighted the importance of supporting families to perform the functions associated
\nwith their parental role and to improve children’s well-being. The aims of this study were to identify and describ…
View article: Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non‐ischaemic dilated cardiomyopathy
Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non‐ischaemic dilated cardiomyopathy Open
Aims Genotype and left ventricular scar on cardiac magnetic resonance (CMR) are increasingly recognized as risk markers for adverse outcomes in non‐ischaemic dilated cardiomyopathy (DCM). We investigated the combined influence of genotype …
View article: Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy
Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy Open
In this study, DCM patients with pathogenic or likely pathogenic variants had worse prognosis than genotype-negative individuals. Clinical course differed depending on the underlying affected gene.
View article: Founder mutation in myosin-binding protein C with an early onset and a high penetrance in males
Founder mutation in myosin-binding protein C with an early onset and a high penetrance in males Open
Objective One of the challenges in hypertrophic cardiomyopathy (HCM) is to determine the pathogenicity of genetic variants and to establish genotype/phenotype correlations. This study aimed to: (1) demonstrate that MYBPC3 c.2149–1G>A is a …
View article: Clinical characteristics and natural history of PRKAG2 syndrome
Clinical characteristics and natural history of PRKAG2 syndrome Open
Purpose Mutations in the PRKAG2 gene cause a syndrome characterized by hypertrophic cardiomyopathy, conduction disease and ventricular preexcitation. Only a small number of cases have been reported, and the natural history of the disease i…
View article: Prospective follow-up in various subtypes of cardiomyopathies: insights from the ESC EORP Cardiomyopathy Registry
Prospective follow-up in various subtypes of cardiomyopathies: insights from the ESC EORP Cardiomyopathy Registry Open
Aims The European Society of Cardiology (ESC) European Observational Research Programme (EORP) Cardiomyopathy Registry is a prospective multinational registry of consecutive patients with cardiomyopathies. The objective of this report is t…
View article: La educación para el desarrollo y los derechos de la infancia: el papel de las agencias internacionales y el impacto de la formación en la transformación de los contextos
La educación para el desarrollo y los derechos de la infancia: el papel de las agencias internacionales y el impacto de la formación en la transformación de los contextos Open
El objetivo del artículo es describir el papel que las agencias internacionales tienen en la educación para el desarrollo desde un enfoque de derechos de la infancia. Considerando, como uno de los principales hitos, la aprobación en 1989 d…
View article: Clinical Features and Natural History of PRKAG2 Variant Cardiac Glycogenosis
Clinical Features and Natural History of PRKAG2 Variant Cardiac Glycogenosis Open
PRKAG2 syndrome is a progressive cardiomyopathy characterized by high rates of atrial fibrillation, conduction disease, advanced heart failure, and life-threatening arrhythmias. Classical features of pre-excitation and severe LVH are not u…
View article: Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry
Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry Open
View article: Negative screening of Fabry disease in patients with conduction disorders requiring a pacemaker
Negative screening of Fabry disease in patients with conduction disorders requiring a pacemaker Open
View article: Role of copy number variants in sudden cardiac death and related diseases: genetic analysis and translation into clinical practice
Role of copy number variants in sudden cardiac death and related diseases: genetic analysis and translation into clinical practice Open
View article: Sudden Death in a Young Patient with Atrial Fibrillation
Sudden Death in a Young Patient with Atrial Fibrillation Open
Sudden cardiac death (SCD) in young patients without structural heart disease is frequently due to inherited channelopathies such as long QT syndrome (LQTS), Brugada syndrome or Catecholaminergic polymorphic ventricular tachycardia. Accord…
View article: Additional value of screening for minor genes and copy number variants in hypertrophic cardiomyopathy
Additional value of screening for minor genes and copy number variants in hypertrophic cardiomyopathy Open
A small percentage of HCM cases without point mutations in the 5 main genes are explained by P/LP variants in minor or candidate genes and CNVs. Screening for variants in TTN in HCM patients drastically increases the number of inconclusive…
View article: P4507Genotype-phenotype correlations in a mediterranean cohort of hypertrophic cardiomyopathy with high prevalence of apical variant
P4507Genotype-phenotype correlations in a mediterranean cohort of hypertrophic cardiomyopathy with high prevalence of apical variant Open
View article: Diffuse myocardial fibrosis - a therapeutic target? Proof of regression at 1-year following aortic valve replacement: the RELIEF-AS study
Diffuse myocardial fibrosis - a therapeutic target? Proof of regression at 1-year following aortic valve replacement: the RELIEF-AS study Open
View article: T1 mapping in severe aortic stenosis: insights into LV remodeling
T1 mapping in severe aortic stenosis: insights into LV remodeling Open