Francisca Arez
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View article: 3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV Open
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the pre-clinical models, resulting in therapy failure. Liver …
View article: 3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV Open
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the preclinical models, resulting in therapy failure. Liver i…
View article: Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems Open
Primary human hepatocytes (PHHs) are the preferred cell source to address liver function. Despite originating from the native tissue, one of the bottlenecks when using primary material is the donor-to-donor variability. Cryopreserved PHHs …
View article: Drug Interaction Studies of Cabamiquine:Ganaplacide Combination against Hepatic <i>Plasmodium berghei</i>
Drug Interaction Studies of Cabamiquine:Ganaplacide Combination against Hepatic <i>Plasmodium berghei</i> Open
New antimalarial combination therapies with novel modes of action are required to counter the emergence and spread of Plasmodium drug resistance against existing therapeutics. Here, we present a study to evaluate the preventive activity of…
View article: Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside Open
Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibit…
View article: Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical <i>Plasmodium</i> Infection Models
Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical <i>Plasmodium</i> Infection Models Open
Combination therapies have emerged to mitigate Plasmodium drug resistance, which has hampered the fight against malaria. M5717 is a potent multistage antiplasmodial drug under clinical development, which inhibits parasite protein synthesis…
View article: Bioengineered Liver Cell Models of Hepatotropic Infections
Bioengineered Liver Cell Models of Hepatotropic Infections Open
Hepatitis viruses and liver-stage malaria are within the liver infections causing higher morbidity and mortality rates worldwide. The highly restricted tropism of the major human hepatotropic pathogens—namely, the human hepatitis B and C v…
View article: iPSC-derived neurospheroids recapitulate development and pathological signatures of human brain microenvironment
iPSC-derived neurospheroids recapitulate development and pathological signatures of human brain microenvironment Open
In present study, the capabilities of multiple linear regression (MLR) and adaptive neuro-fuzzy inference system (ANFIS) in developing pedotransfer functions (PTFs) for estimating geometric mean diameter (GMD) and mean weight diameter (MWD…
View article: Novel in vitro human 3D neural model derived from induced pluripotent stem cells
Novel in vitro human 3D neural model derived from induced pluripotent stem cells Open
The limited access to human neurons has hindered the development of accurate models to mimic human central nervous system (CNS) disease, and consequently the development of efficient therapies for neuropathologies. The current models rely …