María Camila Trillos-Almanza
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View article: Branched‐chain amino acids and all‐cause mortality in patients with liver cirrhosis, and the onset of diabetes in liver transplant recipients
Branched‐chain amino acids and all‐cause mortality in patients with liver cirrhosis, and the onset of diabetes in liver transplant recipients Open
Background and Aims Branched‐chain amino acids ( BCAA ) have gained increasing recognition for their role in liver disease. This study investigated plasma BCAA alterations in patients with cirrhosis and liver transplant recipients ( LTRs )…
View article: Arctigenin Attenuates Hepatic Stellate Cell Activation via Endoplasmic Reticulum-Associated Degradation (ERAD)-Mediated Restoration of Lipid Homeostasis
Arctigenin Attenuates Hepatic Stellate Cell Activation via Endoplasmic Reticulum-Associated Degradation (ERAD)-Mediated Restoration of Lipid Homeostasis Open
Arctigenin, a natural lignan from Arctium lappa L., exhibits potent antifibrotic activity, yet its molecular mechanisms remain unclear. Endoplasmic reticulum (ER) stress is known to promote hepatic stellate cell (HSC) activation and…
View article: Plasma Beta-Hydroxybutyrate and All-Cause Mortality in Patients with Liver Cirrhosis
Plasma Beta-Hydroxybutyrate and All-Cause Mortality in Patients with Liver Cirrhosis Open
Background: Liver cirrhosis is often accompanied by metabolic dysfunction. Circulating β-hydroxybutyrate (BHB), the most abundant ketone body, is an emerging metabolic biomarker of mitochondrial dysfunction. Methods: In this prospective ob…
View article: Plasma GlycA, a Glycoprotein Marker of Chronic Inflammation, and All-Cause Mortality in Cirrhotic Patients and Liver Transplant Recipients
Plasma GlycA, a Glycoprotein Marker of Chronic Inflammation, and All-Cause Mortality in Cirrhotic Patients and Liver Transplant Recipients Open
Low-grade chronic inflammation may impact liver disease. We investigated the extent to which circulating GlycA, a glycoprotein biomarker of low-grade inflammation, and high-sensitivity C-reactive protein (hs-CRP) are altered in patients wi…
View article: Circulating Citrate Is Reversibly Elevated in Patients with End-Stage Liver Disease: Association with All-Cause Mortality
Circulating Citrate Is Reversibly Elevated in Patients with End-Stage Liver Disease: Association with All-Cause Mortality Open
Circulating citrate may serve as a proxy for mitochondrial dysfunction which plays a role in the progression of end-stage liver disease (ESLD). This study aimed to determine the extent of alterations in circulating citrate in patients with…
View article: Branched-chain amino acids and their metabolites decrease human and rat hepatic stellate cell activation
Branched-chain amino acids and their metabolites decrease human and rat hepatic stellate cell activation Open
View article: Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients
Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients Open
Liver transplant recipients (LTRs) have lower long-term survival rates compared with the general population. This underscores the necessity for developing biomarkers to assess post-transplantation mortality. Here we compared plasma trimeth…
View article: Optimization of protocols for blood-derived extracellular vesicles for studies in liver diseases
Optimization of protocols for blood-derived extracellular vesicles for studies in liver diseases Open
Aim: Extracellular vesicles (EVs) have gained significant attention for their diagnostic and therapeutic potential in various diseases, including liver disorders. This study focuses on optimizing the isolation and characterization of small…
View article: Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver
Clinical and Therapeutic Implications of BCAAs Metabolism during Chronic Liver Disease in Humans: Crosstalk between Skeletal Muscle and Liver Open
This comprehensive review focuses on the dynamics of branched-chain amino acids (BCAAs) metabolism and its clinical implications in chronic liver disease, with emphasis on the emerging concept of muscle–liver crosstalk. BCAAs, indispensabl…
View article: Branched Chain Amino Acids Are Associated with Physical Performance in Patients with End-Stage Liver Disease
Branched Chain Amino Acids Are Associated with Physical Performance in Patients with End-Stage Liver Disease Open
Decreased circulating branched chain amino acids (BCAA) represent a prominent change in amino acid profiles in patients with end-stage liver disease (ESLD). These alterations are considered to contribute to sarcopenia and hepatic encephalo…
View article: Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis
Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis Open
Activation of hepatic stellate cells (HSC) is a key event in the initiation of liver fibrosis. Activated HSCs proliferate and secrete excessive amounts of extracellular matrix (ECM), disturbing liver architecture and function, leading to f…
View article: Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications Open
The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steatohepatitis (NASH) with advanced fibrosis o…
View article: Branched chain amino acids are associated with metabolic complications in liver transplant recipients
Branched chain amino acids are associated with metabolic complications in liver transplant recipients Open
Elevated BCAA plasma levels are associated with T2D, MetS and use of Sirolimus in liver transplant recipients. BCAA plasma levels may represent a valuable biomarker for cardiometabolic complications after OLTx.
View article: Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults
Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults Open
Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity.Methods: A cross-sectional study was performed in sedentary adults with or without metabolic syndrom…
View article: How to manage: liver abscess
How to manage: liver abscess Open
The diagnosis of pyogenic liver abscess (PLA) represents a challenge for physicians due to their association with multiple pre-existing conditions.
Its incidence varies between 2.3 and 17.59 per 100 000 inhabitants per year,1–3 and in hos…
View article: Caracterización de pacientes con hepatitis C crónica tratados en un hospital de alta complejidad de Medellín
Caracterización de pacientes con hepatitis C crónica tratados en un hospital de alta complejidad de Medellín Open
Introducción: la hepatitis C (HepC) representa un problema de salud pública a nivel mundial. Se estima que en Colombia la prevalencia de virus de la hepatitis C (VHC) está entre el 0,5-1 %, y asciende al 2,1 % en pacientes mayores de 50 añ…