Maria Clara Zanon Zotin

Association of Blood Pressure Mean and Variability with Hippocampal Subfield Volumes in Cerebral Amyloid Angiopathy with Mild Cognitive Symptoms Open

Lukas Sveikata, Maria Clara Zanon Zotin, Dorothée Schoemaker, Valentina Perosa, Frédéric Assal , et al. · 2024

Background The interaction between Alzheimer's pathology and cerebral amyloid angiopathy (CAA), a common cerebral small vessel disease, plays a crucial role in cognitive impairment development in older adults. Recent studies suggest that i…

Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy Open

Nazanin Makkinejad, Maria Clara Zanon Zotin, Hilde van den Brink, Corinne A. Auger, Kali A. vom Eigen , et al. · 2024

Background White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs in CAA are unclear, and it …

High prevalence of intracranial arterial stenosis among acute ischemic stroke patients in a Brazilian center: a transcranial color-coded duplex sonography study Open

Letícia Januzi de Almeida Rocha, Maria Clara Zanon Zotin, Renata da Silva Almeida Santos, Milena Carvalho Libardi, Millene Rodrigues Camilo , et al. · 2024

Background There is limited data available regarding the prevalence of intracranial arterial stenosis (ICAS) among acute ischemic stroke (AIS) patients in Brazil and Latin America. Objective The present study sought to investigate the freq…

Association of Long-Term Blood Pressure Variability with Cerebral Amyloid Angiopathy-related Brain Injury and Cognitive Decline Open

Lukas Sveikata, Maria Clara Zanon Zotin, Dorothée Schoemaker, Yuan Ma, Valentina Perosa , et al. · 2024

Introduction Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the underlying mechanisms are largely unknown. We aimed to investigate the association between long-term blood pres…

Intravascular Lymphoma: A Diagnostic Challenge for a Treatable Cause of Rapidly Progressive Dementia Open

Trajano Aguiar Pires Gonçalves, Juliana Naback Toniolo, Matheus Compart Hemerly, Maria Clara Zanon Zotin, Anna Letícia de Moraes Alves , et al. · 2024

Acute carotid web thrombosis and early reocclusion after successful thrombectomy: a case report Open

João Miguel Santos, Letícia Escorse Requião, Victória Sabbado Menezes, Atsushi ESAKI, Luis O.B. Afonso , et al. · 2024

Case presentation: A 58-year-old Black woman presented with sudden onset aphasia, right-sided weakness, and numbness 11 hours prior to admission at the Emergency Unit. On examination, her NIHSS score was 13, indicating a left middle cerebr…

Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy Open

Valentina Perosa, Maria Clara Zanon Zotin, Dorothée Schoemaker, Lukas Sveikata, Mark R. Etherton , et al. · 2023

These results suggest that hippocampal integrity is an independent contributor to cognitive impairment in patients with CAA and that it might be related to loss of integrity in the white matter. Further studies exploring potential causes a…

Sensitivity and Specificity of the Boston Criteria Version 2.0 for the Diagnosis of Cerebral Amyloid Angiopathy in a Community-Based Sample Open

Maria Clara Zanon Zotin, Nazanin Makkinejad, Julie A. Schneider, Konstantinos Arfanakis, Andreas Charidimou , et al. · 2023

This study provides Class II evidence that the Boston criteria v2.0 accurately distinguishes people with CAA from those without CAA.

The Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy Open

Nazanin Makkinejad, Maria Clara Zanon Zotin, Hilde van den Brink, Corinne A. Auger, Juan Eugenio Iglesias , et al. · 2023

Background Cerebral amyloid angiopathy (CAA) is a common cause of intracerebral hemorrhage and cognitive impairment in older individuals. Hallmark manifestations of CAA on MRI include cortical hemorrhages, as well as perivascular spaces (P…

Dilated optic nerve sheath by ultrasound predicts mortality among patients with acute intracerebral hemorrhage Open

Francisco Antunes Dias, Maria Clara Zanon Zotin, Frederico Fernandes Alessio-Alves, Rui Martins, Clara Barreira , et al. · 2023

Background Intracerebral hemorrhage (ICH) is a deadly disease and increased intracranial pressure (ICP) is associated with worse outcomes in this context. Objective We evaluated whether dilated optic nerve sheath diameter (ONSD) depicted b…

Histopathological Correlates of Lobar Microbleeds in False‐Positive Cerebral Amyloid Angiopathy Cases Open

Valentina Perosa, Corinne A. Auger, Maria Clara Zanon Zotin, Jan Oltmer, Matthew P. Frosch , et al. · 2023

Objective A definite diagnosis of cerebral amyloid angiopathy (CAA), characterized by the accumulation of amyloid β in walls of cerebral small vessels, can only be obtained through pathological examination. A diagnosis of probable CAA duri…

Peak width of skeletonized mean diffusivity and cognitive performance in cerebral amyloid angiopathy Open

Mitchell J Horn, Elif Gökçal, Jana Becker, Alvin S. Das, Kristin Schwab , et al. · 2023

Background Cerebral Amyloid Angiopathy (CAA) is a cerebral small vessel disease that can lead to microstructural disruption of white matter (WM), which can be measured by the Peak Width of Skeletonized Mean Diffusivity (PSMD). We hypothesi…

Apathy in Patients With Cerebral Amyloid Angiopathy Open

Anthipa Chokesuwattanaskul, Maria Clara Zanon Zotin, Dorothée Schoemaker, Lukas Sveikata, M. Edip Gurol , et al. · 2023

Our findings revealed the orbitofrontal cortex as a key region in the reward circuit associated with apathy in sporadic cerebral amyloid angiopathy, independent from depression. Apathy was shown to be associated with a higher CAA-SVD score…

Peak Width of Skeletonized Mean Diffusivity: A Neuroimaging Marker for White Matter Injury Open

Maria Clara Zanon Zotin, Pınar Yilmaz, Lukas Sveikata, Dorothée Schoemaker, Susanne J. van Veluw , et al. · 2023

A leading cause of white matter (WM) injury in older individuals is cerebral small vessel disease (SVD). Cerebral SVD is the most prevalent vascular contributor to cognitive impairment and dementia. Therapeutic progress for cerebral SVD an…

Elderly man presenting with focal seizures, encephalopathy and tumefactive lesion on imaging scans Open

Gabriela Lopes de Morais, Ellen Silva de Carvalho, Anny Karoliny de Santana Nogueira, Sarah Lima Ribeiro, Elisa Coutinho Moura , et al. · 2023

An 84-year-old man with cardiomyopathy and a pacemaker was admitted to our hospital due to a focal impaired awareness seizure. Computed tomography (CT) scan on admittance evidenced right parieto-occipital hypodensity with mild mass effect.…

Influence of cerebral blood flow on volumetric loss related to Alzheimer’s disease Open

Maria Izaura Sedoguti Scudeler Agnollitto, Renata Ferranti Leoni, Maria Paula Foss, Julia Palaretti, Marcela Cayres , et al. · 2023

CBF measured with Arterial Spin Labeling (ASL) obtained by Magnetic Resonance Imaging (MRI) may become an important biomarker by showing changes in early stages of AD, such as in the prodromal stage of Mild Cognitive Impairment (MCI). Obje…

Peak width of skeletonized mean diffusivity in cerebral amyloid angiopathy: Spatial signature, cognitive, and neuroimaging associations Open

Maria Clara Zanon Zotin, Dorothée Schoemaker, Nicolas Raposo, Valentina Perosa, Martin Bretzner , et al. · 2022

Background Peak width of skeletonized mean diffusivity (PSMD) is a promising diffusion tensor imaging (DTI) marker that shows consistent and strong cognitive associations in the context of different cerebral small vessel diseases (cSVD). P…

A Causal Classification System for Intracerebral Hemorrhage Subtypes Open

Nicolas Raposo, Maria Clara Zanon Zotin, David Seiffge, Qi Li, Martina Goeldlin , et al. · 2022

Objective Determining the underlying causes of intracerebral hemorrhage (ICH) is of major importance, because risk factors, prognosis, and management differ by ICH subtype. We developed a new causal CLASsification system for ICH Subtypes, …

Keeping our balance in cerebellar ataxia: the contribution of neuroimaging to clinical investigation Open

Maria Clara Zanon Zotin · 2022

Peak width of skeletonized mean diffusivity (PSMD) as neuroimaging biomarker for vascular cognitive impairment in the context of cerebral amyloid angiopathy Open

Maria Clara Zanon Zotin · 2022

\n Introduction - An unmet need in the field of cerebral small vessel diseases (cSVDs) is how to measure the widespread white matter (WM) injury that underlies vascular cognitive impairment in a feasible and clinically meaningful way. Thou…

White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia Open

Dorothée Schoemaker, Maria Clara Zanon Zotin, Kewei Chen, Kay C. Igwe, Clara Vila‐Castelar , et al. · 2022

Corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy Open

Whitney M. Freeze, Maria Clara Zanon Zotin, Ashley A. Scherlek, Valentina Perosa, Corinne A. Auger , et al. · 2022

The impact of vascular lesions on cognition is location dependent. Here, we assessed the contribution of small vessel disease lesions in the corpus callosum to vascular cognitive impairment in cerebral amyloid angiopathy, as a model for ce…

Radiomic signature of DWI‐FLAIR mismatch in large vessel occlusion stroke Open

Robert W. Regenhardt, Martin Bretzner, Maria Clara Zanon Zotin, Anna K. Bonkhoff, Mark R. Etherton , et al. · 2021

Background and Purpose Ischemic diffusion‐weighted imaging‐fluid‐attenuated inversion recovery (DWI‐FLAIR) mismatch may be useful in guiding acute stroke treatment decisions given its relationship to onset time and parenchymal viability; h…

Cranial US in Infants Exposed to Zika Virus: The NATZIG Cohort Open

Sara Reis Teixeira, Jorge Elías, Conrado Milani Coutinho, Maria Clara Zanon Zotin, Aparecida Yulie Yamamoto , et al. · 2021

Background Studies addressing neuroimaging findings as primary outcomes of congenital Zika virus infection are variable regarding inclusion criteria and confirmatory laboratory testing. Purpose To investigate cranial US signs of prenatal Z…

Association of Memory Impairment With Concomitant Tau Pathology in Patients With Cerebral Amyloid Angiopathy Open

Dorothée Schoemaker, Andreas Charidimou, Maria Clara Zanon Zotin, Nicolas Raposo, Keith A. Johnson , et al. · 2021

This study provides Class II evidence that tau-PET retention is related to the presence of objective memory impairment in patients with CAA.

Peak Width of Skeletonized Mean Diffusivity as Neuroimaging Biomarker in Cerebral Amyloid Angiopathy Open

Nicolas Raposo, Maria Clara Zanon Zotin, Dorothée Schoemaker, Li Xiong, Panagiotis Fotiadis , et al. · 2021

Peak width of skeletonized mean diffusivity is altered in cerebral amyloid angiopathy and is associated with performance in processing speed. This DTI-based method may reflect the degree of white matter structural disruption in cerebral am…

Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management Open

Maria Clara Zanon Zotin, Lukas Sveikata, Anand Viswanathan, Pınar Yilmaz · 2021

Purpose of review We present recent developments in the field of small vessel disease (SVD)-related vascular cognitive impairment, including pathological mechanisms, updated diagnostic criteria, cognitive profile, neuroimaging markers and …

Strategic corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy Open

Whitney M. Freeze, Maria Clara Zanon Zotin, Andrew D. Warren, Louise van der Weerd, M. Edip Gurol , et al. · 2020

Background Cerebral amyloid angiopathy (CAA) is highly prevalent in Alzheimer’s disease (AD) and is associated with hemorrhagic and ischemic brain lesions. CAA is increasingly recognized as an important independent cause of cognitive impai…

Memory impairment is a clinical marker of tau pathology in cerebral amyloid angiopathy Open

Dorothée Schoemaker, Andreas Charidimou, Maria Clara Zanon Zotin, Nicolas Raposo, Keith A. Johnson , et al. · 2020

Background Cerebral Amyloid Angiopathy (CAA) shows a high comorbidity with Alzheimer’s Disease (AD). Nonetheless, CAA is an independent neuropathological disorder, and over half of CAA cases present without AD‐related tau pathology. Differ…

CT-Visible Convexity Subarachnoid Hemorrhage is Associated With Cortical Superficial Siderosis and Predicts Recurrent ICH Open

Qi Li, Maria Clara Zanon Zotin, Andrew D. Warren, Yuan Ma, M. Edip Gurol , et al. · 2020

This study provides Class II evidence that cSAH accurately predicts recurrent stroke in patients with CAA.

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