Maria Dalby
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View article: Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study
Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study Open
Background Attentional control is a critical component of executive functioning involved in numerous psychiatric and neurological disorders, yet its etiological relationships with many cognitive and behavioral phenotypes remain underexplor…
View article: TREM2 Agonism Affects Human Microglia Response in the Presence of Amyloid Pathology In Vivo
TREM2 Agonism Affects Human Microglia Response in the Presence of Amyloid Pathology In Vivo Open
Background Pharmacological activation of TREM2 represents a novel therapeutic approach to slow Alzheimer´s disease (AD) progression. Mutations in microglial gene, TREM2, confers increased risk to developing late‐onset AD. Moreover, animal …
View article: The association between persistent cognitive difficulties and depression and functional outcomes in people with major depressive disorder
The association between persistent cognitive difficulties and depression and functional outcomes in people with major depressive disorder Open
Background Cognitive symptoms are common during and following episodes of depression. Little is known about the persistence of self-reported and performance-based cognition with depression and functional outcomes. Methods This is a seconda…
View article: Polygenic heterogeneity in antidepressant treatment and placebo response
Polygenic heterogeneity in antidepressant treatment and placebo response Open
The genetic architecture of antidepressant response is poorly understood. Polygenic risk scores (PRS), exploration of placebo response and the use of sub-scales might provide insights. Here, we investigate the association between PRSs for …
View article: The association between persistent cognitive difficulties and depression and functional outcomes in people with Major Depressive Disorder
The association between persistent cognitive difficulties and depression and functional outcomes in people with Major Depressive Disorder Open
Background: Cognitive symptoms are common during and following episodes of depression. Little is known about the persistence of self-reported and performance-based cognition with depression and functional outcomes. Methods: This is a secon…
View article: Further validation of the THINC‐it tool and extension of the normative data set in a study of<i>n</i> = 10.019 typical controls
Further validation of the THINC‐it tool and extension of the normative data set in a study of<i>n</i> = 10.019 typical controls Open
Introduction We report further validation and normative data for the THINC‐Integrated Tool (THINC‐it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in fur…
View article: Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US
Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US Open
There has recently been marked progress in identifying genetic risk factors for major depression (MD) and bipolar disorder (BD); however, few systematic efforts have been made to elucidate heterogeneity that exists within and across these …
View article: Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network Open
View article: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network Open
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a spe…
View article: Fantom5 Transcribed Enhancers In Mm10
Fantom5 Transcribed Enhancers In Mm10 Open
Overview Transcribed enhancers were identified and their expression was quantified across all human FANTOM5 libraries, following the re-aligned FANTOM5 CAGE data upon mm10 (GRCm38) (obtained from http://fantom.gsc.riken.jp…
View article: Fantom5 Transcribed Enhancers In Mm10
Fantom5 Transcribed Enhancers In Mm10 Open
Overview Transcribed enhancers were identified and their expression was quantified across all human FANTOM5 libraries, following the re-aligned FANTOM5 CAGE data upon mm10 (GRCm38) (obtained from http://fantom.gsc.riken.jp…
View article: MCM2 promotes symmetric inheritance of modified histones during DNA replication
MCM2 promotes symmetric inheritance of modified histones during DNA replication Open
How cells ensure symmetric inheritance Parental histones with modifications are recycled to newly replicated DNA strands during genome replication, but do the two sister chromatids inherit modified histones equally? Yu et al. and Petryk et…
View article: Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities
Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities Open
Mammalian gene promoters and enhancers share many properties. They are composed of a unified promoter architecture of divergent transcripton initiation and gene promoters may exhibit enhancer function. However, it is currently unclear how …
View article: Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions
Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions Open
View article: Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes Open
View article: Transcription start site analysis reveals widespread divergent transcription in <i>D. melanogaster</i> and core promoter-encoded enhancer activities
Transcription start site analysis reveals widespread divergent transcription in <i>D. melanogaster</i> and core promoter-encoded enhancer activities Open
Mammalian gene promoters and enhancers share many properties. They are composed of a unified promoter architecture of divergent transcripton initiation and gene promoters may exhibit enhancer function. However, it is currently unclear how …
View article: Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions
Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions Open
Transcriptional regulation is tightly coupled with chromosomal positioning and three-dimensional chromatin architecture. However, it is unclear what proportion of transcriptional activity is reflecting such organisation, how much can be in…
View article: Transcriptional Decomposition Reveals Active Chromatin Architectures And Cell Specific Regulatory Interactions
Transcriptional Decomposition Reveals Active Chromatin Architectures And Cell Specific Regulatory Interactions Open
Summary Resource data across the 76 cell types from FANTOM5 analysed in our paper titled "Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions". Project abs…
View article: Fantom5 Transcribed Enhancers In Hg38
Fantom5 Transcribed Enhancers In Hg38 Open
Overview Transcribed enhancers were identified and their expression was quantified across all human FANTOM5 libraries, following the re-aligned FANTOM5 CAGE data upon hg38 (GRCh38) (obtained from http://fantom.gsc.riken.jp…