Maria Dimitrova
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View article: In situ development of an artificial intelligence (AI) model for early detection of adverse drug reactions (ADRs) to ensure drug safety
In situ development of an artificial intelligence (AI) model for early detection of adverse drug reactions (ADRs) to ensure drug safety Open
Pharmacovigilance is a vital component of public health systems, aiming to ensure the safe use of medicinal products. In this study, an artificial intelligence (AI)-based model was developed using TensorFlow to predict the likelihood of ad…
View article: Incorporating cost considerations into shared decision-making: lessons from Bulgaria
Incorporating cost considerations into shared decision-making: lessons from Bulgaria Open
This study aims to explore the need for and acceptability of incorporating treatment costs into shared decision-making (SDM) among patients and healthcare providers (HCPs) in Bulgaria. This study is a qualitative, non-interventional evalua…
View article: How Medicinal is Dried Angelica archangelica Relative to the Fresh Plant?
How Medicinal is Dried Angelica archangelica Relative to the Fresh Plant? Open
The chemical composition of natural products is responsible for their medicinal properties. Angelica archangelica is known for its antimicrobial properties, which stem from terpenes that make up the bulk of the extract of the fresh plant. …
View article: Outcomes of a Risk-Stratified Protocol for Preventing Peristomal Skin Complications in Patients with an Ostomy: A Cohort Study
Outcomes of a Risk-Stratified Protocol for Preventing Peristomal Skin Complications in Patients with an Ostomy: A Cohort Study Open
Background/Objectives: Peristomal skin complications (PSCs) are common among patients with ostomies, significantly impacting quality of life and increasing healthcare utilization. This study aimed to evaluate the effects of the Dermamecum …
View article: Incidence, patient characteristics and treatment patterns of early-stage triple-negative breast cancer (TNBC) in Bulgaria: A retrospective analysis based on real-world data
Incidence, patient characteristics and treatment patterns of early-stage triple-negative breast cancer (TNBC) in Bulgaria: A retrospective analysis based on real-world data Open
Breast cancer (BC) is the third most common cancer, making up 10.8% of cases in both men and women. In Bulgaria, it has the highest rates of diagnosis (23.3%) and death among women, with around 3558 new cases each year, 5–7% of which are a…
View article: Opportunities for implementing digital applications to monitor the impact of risk-minimization measures within the pharmacovigilance process: Scoping review of published literature
Opportunities for implementing digital applications to monitor the impact of risk-minimization measures within the pharmacovigilance process: Scoping review of published literature Open
The study provides an overview of innovative digital solutions to meet the evolving needs of drug safety monitoring and improve patient outcomes, focusing on implementing digital applications to enhance the monitoring of additional risk-mi…
View article: From Space to Health: The Impact of Earth Observation Research on the Smart4COV19 Telemedicine project
From Space to Health: The Impact of Earth Observation Research on the Smart4COV19 Telemedicine project Open
This study investigates the potential of Earth observation research in improving air quality management and supporting telemedicine initiatives in response to the COVID-19 pandemic. Utilizing ground stations in Sofia and Burgas, we collect…
View article: Adverse Drug Reactions of Cardiovascular Classes of Medicines—Data for Bulgarian Population
Adverse Drug Reactions of Cardiovascular Classes of Medicines—Data for Bulgarian Population Open
Objective: Hypertensionis one of the most common chronic diseases, affecting more than 20% of the population. The side effects experienced due to antihypertensive medications, such as tiredness, muscle pain, and insomnia, are often a signi…
View article: Proton therapy for head and neck cancer therapy: A real-world data case study from Bulgaria
Proton therapy for head and neck cancer therapy: A real-world data case study from Bulgaria Open
Head and neck cancers (HNC) are one of the most severe types of cancer in Europe, accounting for almost 4.5% of all cancer types, according to GLOBOCAN. The incidence is geographically variable, with higher rates observed in Eastern and So…
View article: Role of pharmacists in adherence in oncology patients
Role of pharmacists in adherence in oncology patients Open
Adherence is the degree to which the patient’s behaviour and actions correspond to the physician’s established treatment regimen regarding timing, dose and frequency. Patient counselling by both oncologists and pharmacists and optimization…
View article: Economic consequences of the implementation of primary DNA-HPV genotype testing in Bulgaria
Economic consequences of the implementation of primary DNA-HPV genotype testing in Bulgaria Open
There is a global call for action for cervical cancer elimination as a public health problem—WHO Strategy 90-70-90. One of the strategic pillars, alongside vaccination, is cervical cancer screening. This aims to assess the economic consequ…
View article: Prosocial Behavior and Organizational Climate: A Multifactor Analysis
Prosocial Behavior and Organizational Climate: A Multifactor Analysis Open
This publication explores the impact of prosocial behavior within organizational settings, focusing on its connection to organizational climate. Utilizing various empirical and theoretical sources, this paper addresses the key internal and…
View article: Personality and Situational Factors Influencing Prosocial Behavior in Organizational Contexts
Personality and Situational Factors Influencing Prosocial Behavior in Organizational Contexts Open
This paper examines the personality and situational factors that shape prosocial behavior in organizations, analyzing the impact of organizational climate, leadership styles, and individual traits. Employing both theoretical and empirical …
View article: COST-EFFECTIVENESS OF DISEASE-MODIFYING TREATMENTS FOR MULTIPLE SCLEROSIS IN BULGARIA BASED ON EVIDENCE FROM REAL WORLD SETTINGS
COST-EFFECTIVENESS OF DISEASE-MODIFYING TREATMENTS FOR MULTIPLE SCLEROSIS IN BULGARIA BASED ON EVIDENCE FROM REAL WORLD SETTINGS Open
This study aims to provide insight into the early application of high efficacy 2 nd line DMDs (disease-modifying drugs) from a Bulgarian public payer perspective, referring to RWD (real-world data).An Excel-based model was developed to com…
View article: Decentralized Clinical Trials – Current Environment, Potential Barriers and Facilitators for Implementation and Risk Mitigation: A Review of the Literature
Decentralized Clinical Trials – Current Environment, Potential Barriers and Facilitators for Implementation and Risk Mitigation: A Review of the Literature Open
Introduction Decentralized clinical trials are a new approach in health technology research and development that take advantage of innovative digital technologies in data collection for clinical trial purposes. Decentralized clinical trial…
View article: Analysis Of Patients' Opinion Of Prescribed Medicines: A Questionnaire - Based Pilot Study In Bulgaria
Analysis Of Patients' Opinion Of Prescribed Medicines: A Questionnaire - Based Pilot Study In Bulgaria Open
Evaluation of rational drug utilization (RDU) through WHO indicators is used to provide information about the level of development of national policy and to identify the necessity of further regulatory, patients or healthcare professionals…
View article: Digital health in Bulgaria: Imagination or possible reality?
Digital health in Bulgaria: Imagination or possible reality? Open
Digital health is an emerging, strategic health priority for years. Even prior to the COVID-19 pandemic, the use of digital health technologies to make health systems and services more effective was widely recognized. Many countries around…
View article: Editorial: Advances in the potential treatments of gastrointestinal and liver diseases: addressing the public health burden
Editorial: Advances in the potential treatments of gastrointestinal and liver diseases: addressing the public health burden Open
The present Research Topic consists of twenty articles: 3 systematic reviews with meta-analysis, 3 reviews, and 14 original research articles. These articles provide a diverse range of innovative viewpoints on the significance of comprehen…
View article: Recommendations for patient involvement in health technology assessment in Central and Eastern European countries
Recommendations for patient involvement in health technology assessment in Central and Eastern European countries Open
Introduction Meaningful patient involvement in health technology assessment (HTA) is essential in ensuring that the interests of the affected patient population, their families, and the general public are accurately reflected in coverage a…
View article: Cost-effectiveness of disease-modifying treatments for multiple sclerosis in Bulgaria based on evidence from real world settings
Cost-effectiveness of disease-modifying treatments for multiple sclerosis in Bulgaria based on evidence from real world settings Open
Background : This study aims to provide insight on the early application of high efficacy 2 nd line DMDs from Bulgarian public payer perspective, referring to RWD. Methods: An Excel-based model was developed to compare the effectiveness of…
View article: Awareness of healthcare professionals about risk minimization measures associated with COVID-19 vaccines: international cross-sectional study
Awareness of healthcare professionals about risk minimization measures associated with COVID-19 vaccines: international cross-sectional study Open
The Coronavirus 2019 (COVID-19) pandemic caused the global healthcare to face one of the most significant challenges since the World Health Organization was founded over 70 years ago. The development and approval of marketing authorization…
View article: Treatment patterns, adherence to international guidelines, and financial mechanisms of the market access of advanced breast cancer therapy in Bulgaria
Treatment patterns, adherence to international guidelines, and financial mechanisms of the market access of advanced breast cancer therapy in Bulgaria Open
Introduction Breast cancer is the most common type of cancer affecting women in Europe. Advanced breast cancer (ABC) poses a significant therapeutic challenge, and therefore, timely access to treatment is crucial. The aim of the present st…
View article: Guidance on using real-world evidence from Western Europe in Central and Eastern European health policy decision making
Guidance on using real-world evidence from Western Europe in Central and Eastern European health policy decision making Open
Aim: Real-world data and real-world evidence (RWE) are becoming more important for healthcare decision making and health technology assessment. We aimed to propose solutions to overcome barriers preventing Central and Eastern European (CEE…
View article: Methodological Quality of Retrospective Observational Studies Investigating Effects of Diabetes Monitoring Systems: a Systematic Review
Methodological Quality of Retrospective Observational Studies Investigating Effects of Diabetes Monitoring Systems: a Systematic Review Open
Background Retrospective observational studies (ROSs) have been frequently used to investigate treatment effects of diabetes monitoring systems (DMS), i.e. medical devices to monitor blood glucose. However, due to quality concerns, the fin…
View article: Space Distribution of NO2 Pollution over Bulgaria
Space Distribution of NO2 Pollution over Bulgaria Open
In this work, we aim to track the behaviour of nitrogen dioxide over Bulgaria for the period 30th April 2018 to the end of July 2022 based on data from the Sentinel 5P data. We conclude that the biggest pollutant still remains the industri…