Maria Donaldson Collier
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View article: Fasting boosts breast cancer therapy efficacy via glucocorticoid activation
Fasting boosts breast cancer therapy efficacy via glucocorticoid activation Open
The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocr…
View article: TRIM24 as a therapeutic target in endocrine treatment–resistant breast cancer
TRIM24 as a therapeutic target in endocrine treatment–resistant breast cancer Open
While Estrogen receptor alpha (ERα)+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since ERα is still the main driver in most therapy-resistant tumors, alternative therapeutic strategies are ne…
View article: 3′-end ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editors
3′-end ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editors Open
Gene editing makes precise changes in DNA to restore normal function or expression of genes; however, the advancement of gene editing to the clinic is limited by the potential genotoxicity of off-target editing. To comprehensively identify…
View article: Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions
Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions Open
Estrogen Receptor 1 (ESR1; also known as ERα, encoded by ESR1 gene) is the main driver and prime drug target in luminal breast cancer. ESR1 chromatin binding is extensively studied in cell lines and a limited number of human tumors, using …
View article: Estrogen Receptor α/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer
Estrogen Receptor α/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer Open
Summary Endocrine resistance in breast cancer treatment is a major clinical hurdle, causing an urgent need for alternative treatment modalities. The suppressive protein-protein interaction (PPI) between Estrogen Receptor alpha (ERα) and th…
View article: Breast cancer risk SNPs converge on estrogen receptor binding sites commonly shared between breast tumors to locally alter estrogen signalling output
Breast cancer risk SNPs converge on estrogen receptor binding sites commonly shared between breast tumors to locally alter estrogen signalling output Open
Estrogen Receptor alpha (ERα) is the main driver and prime drug target in luminal breast. ERα chromatin binding is extensively studied in cell lines and a limited number of human tumors, using consensi of peaks shared among samples. Howeve…
View article: Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Figure S1: RNA sequencing and pathway analysis of CTCs from Bone(+) versus Visceral(+) breast cancer patients. Supplementary Figure S2: Correlation between AR expression and AR signatures. Supplementary Figure S3: ER and PR e…
View article: Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Table S1: Patients and clinical information. Supplementary Table S2: Genes used to determine the AR signature.
View article: Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Figures S1 - S10 from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Figure S1: RNA sequencing and pathway analysis of CTCs from Bone(+) versus Visceral(+) breast cancer patients. Supplementary Figure S2: Correlation between AR expression and AR signatures. Supplementary Figure S3: ER and PR e…
View article: Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Supplementary Tables from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Supplementary Table S1: Patients and clinical information. Supplementary Table S2: Genes used to determine the AR signature.
View article: Data from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Data from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing was performed of circulating tumor cells (CTC) isolated from blood samples of wo…
View article: Data from AR Expression in Breast Cancer CTCs Associates with Bone Metastases
Data from AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing was performed of circulating tumor cells (CTC) isolated from blood samples of wo…
View article: UMI-4C data from Sungalee et al. for lymphoma cell lines
UMI-4C data from Sungalee et al. for lymphoma cell lines Open
UMI-4C datasets generated in Sungalee et al. are provided as raw fastq sequencing files The following target_regions/lymphoma cell lines/conditions are available: BCL11A WSU-DLCL2 DMSO BCL11A WSU-DLCL2 A-485 48h BCL11A DoHH2 Vector BCL11A …
View article: ChIPSeq data from Sungalee et al. 2021
ChIPSeq data from Sungalee et al. 2021 Open
ChIPSeq data generated in Sungalee et al. are provided as bamfiles WSU-DLCL2 DMSO H3K27ac Rep1 WSU-DLCL2 DMSO H3K27ac Rep2 WSU-DLCL2 DMSO H3K36me3 Rep1 WSU-DLCL2 DMSO H3K36me3 Rep2 CTCF Karpas-422 DMSO Rep1 CTCF Karpas-422 DMSO Rep2 CTCF K…
View article: HiC matrices from Sungalee et al. for lymphoma cell lines
HiC matrices from Sungalee et al. for lymphoma cell lines Open
Hi-C datasets generated in Sungalee et al. are provided as intra-chromosomal contact lists and matrices, divided by cell line/condition and chromosome. The following lymphoma cell lines/conditions are available: - WSU-DLCL2 (WSU_A485 treat…
View article: RNASeq data (1) from Sungalee et al. for lymphoma cell lines
RNASeq data (1) from Sungalee et al. for lymphoma cell lines Open
RNASeq datasets (1) generated in Sungalee et al. are provided as raw fastq sequencing files
View article: RNASeq data (2) from Sungalee et al. for lymphoma cell lines
RNASeq data (2) from Sungalee et al. for lymphoma cell lines Open
RNASeq data from Sungalee et al. for lymphoma cell lines
View article: UMI-4C data from Sungalee et al. for lymphoma cell lines
UMI-4C data from Sungalee et al. for lymphoma cell lines Open
UMI-4C datasets generated in Sungalee et al. are provided as raw fastq sequencing files The following target_regions/lymphoma cell lines/conditions are available: BCL11A WSU-DLCL2 DMSO BCL11A WSU-DLCL2 A-485 48h BCL11A DoHH2 Vector BCL11A …
View article: RNASeq data (1) from Sungalee et al. for lymphoma cell lines
RNASeq data (1) from Sungalee et al. for lymphoma cell lines Open
RNASeq datasets (1) generated in Sungalee et al. are provided as raw fastq sequencing files
View article: ChIPSeq data from Sungalee et al. 2021
ChIPSeq data from Sungalee et al. 2021 Open
ChIPSeq data generated in Sungalee et al. are provided as bamfiles WSU-DLCL2 DMSO H3K27ac Rep1 WSU-DLCL2 DMSO H3K27ac Rep2 WSU-DLCL2 DMSO H3K36me3 Rep1 WSU-DLCL2 DMSO H3K36me3 Rep2 CTCF Karpas-422 DMSO Rep1 CTCF Karpas-422 DMSO Rep2 CTCF K…
View article: HiC matrices from Sungalee et al. for lymphoma cell lines
HiC matrices from Sungalee et al. for lymphoma cell lines Open
Hi-C datasets generated in Sungalee et al. are provided as intra-chromosomal contact lists and matrices, divided by cell line/condition and chromosome. The following lymphoma cell lines/conditions are available: - WSU-DLCL2 (WSU_A485 treat…
View article: RNASeq data (2) from Sungalee et al. for lymphoma cell lines
RNASeq data (2) from Sungalee et al. for lymphoma cell lines Open
RNASeq data from Sungalee et al. for lymphoma cell lines
View article: A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer
A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer Open
Epigenetics plays an important role in cancer development and progression. Cancer cells hijack the epigenome by modifying the histone protein units responsible for packaging DNA, or by modifying the DNA itself, resulting in changes to chro…
View article: Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma
Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma Open
Key Points Inhibition of BTK in patients who are resistant to ibrutinib changes signaling tumor dependencies and promotes MYC upregulation. Multitarget inhibition of LYN, FYN, and BLK is therapeutically effective in patients with DLBCL ind…
View article: AR Expression in Breast Cancer CTCs Associates with Bone Metastases
AR Expression in Breast Cancer CTCs Associates with Bone Metastases Open
Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing was performed of circulating tumor cells (CTC) isolated from blood samples of wo…
View article: Intrachromosomal Hi-C Matrices Of Lymphoma Cell Lines
Intrachromosomal Hi-C Matrices Of Lymphoma Cell Lines Open
Intrachromosomal Hi-C matrices in .hic format that can be visualized with JuiceBox software. The following lymphoma cell lines/conditions are available: - Karpas-422 (KARPAS_DMSO and KARPAS_GSK treatment) - WSU-DLCL2 (WSU_DMSO and WSU_GSK…
View article: Intrachromosomal Hi-C Contact Lists And Matrices Of Lymphoma Cell Lines
Intrachromosomal Hi-C Contact Lists And Matrices Of Lymphoma Cell Lines Open
Hi-C datasets generated in Donaldson, Sungalee, Zufferey, Tavernari et al. are provided as intrachromosomal contact lists and matrices, divided by cell line/condition and chromosome. The following lymphoma cell lines/conditions are availa…
View article: Intrachromosomal Hi-C Contact Lists And Matrices Of Lymphoma Cell Lines
Intrachromosomal Hi-C Contact Lists And Matrices Of Lymphoma Cell Lines Open
Hi-C datasets generated in Donaldson, Sungalee, Zufferey, Tavernari et al. are provided as intrachromosomal contact lists and matrices, divided by cell line/condition and chromosome. The following lymphoma cell lines/conditions are availa…