Maria Elena Flacco
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View article: Sleep Disturbances Across Dementias and Cognitive Decline: Study Protocol for a Systematic Review and Network Meta-Analysis of Polysomnographic Findings
Sleep Disturbances Across Dementias and Cognitive Decline: Study Protocol for a Systematic Review and Network Meta-Analysis of Polysomnographic Findings Open
Sleep disturbances are increasingly recognized as early and clinically meaningful features in the pathophysiology of neurodegenerative diseases. Polysomnography (PSG), i.e., the gold standard for objectively characterizing sleep architectu…
View article: Predictors of Weight Reduction in a Multidisciplinary Community Program for Children with Overweight and Obesity: A Study from Emilia-Romagna, Italy
Predictors of Weight Reduction in a Multidisciplinary Community Program for Children with Overweight and Obesity: A Study from Emilia-Romagna, Italy Open
Background: The worldwide prevalence of obesity in children and adolescents quadrupled in the past decades, becoming a public health priority. Following the recommendation by the Italian Minister of Health, the Emilia-Romagna Region starte…
View article: Clinical Utility of Remote Teleassessment of Motor Performance in Individuals With Neurologic Disabilities: A COSMIN Systematic Review
Clinical Utility of Remote Teleassessment of Motor Performance in Individuals With Neurologic Disabilities: A COSMIN Systematic Review Open
Several measurement tools have been identified for remote evaluation of motor performance in people with neurologic disorders, but few of them can be suggested for clinical and scientific purposes. A higher methodological quality of studie…
View article: Assessing vaccination intentions and perceptions among pregnant women in Italy: A multicenter cross-sectional study in the context of mandatory policies and the COVID-19 pandemic
Assessing vaccination intentions and perceptions among pregnant women in Italy: A multicenter cross-sectional study in the context of mandatory policies and the COVID-19 pandemic Open
These findings highlight the crucial role of healthcare professionals in shaping positive vaccination intentions, providing valuable insights for policymakers seeking to enhance vaccination coverage in the post-pandemic era.
View article: Predictors of epilepsy as presenting symptom of cerebral cavernomas
Predictors of epilepsy as presenting symptom of cerebral cavernomas Open
Background: Cerebral cavernous malformations (CCMs) are vascular lesions frequently presenting with seizures on presentation. Studies have widely analyzed topography as a determinant of epileptogenesis. However, the association between les…
View article: Prevalence of Hepatitis C in the Emilia-Romagna Region of Italy: Population-Wide Screening
Prevalence of Hepatitis C in the Emilia-Romagna Region of Italy: Population-Wide Screening Open
In agreement with WHO recommendations, the Emilia-Romagna Region, Italy, implemented a population-wide HCV screening program for the treatment of the large asymptomatic infected population. From January 2022, the free-of-charge screening t…
View article: Outcomes of intended temporary stomas in Crohn's disease (INTESTINE study): international, multicentre, retrospective study
Outcomes of intended temporary stomas in Crohn's disease (INTESTINE study): international, multicentre, retrospective study Open
Background Patients with ileocolic Crohn’s disease often require surgery that can result in temporary stoma formation. Stomas are associated with a morbidity and can negatively impact quality of life. This study aimed to investigate the sh…
View article: Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy
Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy Open
Decompressive craniectomy (DC) is a critical surgical intervention for elevated intracranial pressure. However, the impact of preoperative antiplatelet or anticoagulant therapy on outcomes and complications remains unclear. A retrospective…
View article: Vaccination hesitancy: agreement between WHO and ChatGPT-4.0 or Gemini Advanced.
Vaccination hesitancy: agreement between WHO and ChatGPT-4.0 or Gemini Advanced. Open
The rate of agreement between WHO answers and Chat-GPT-4.0 or Gemini Advanced was very high, as both provided 36 (94.7%) appropriate responses. The few discrepancies between WHO and AI-chatbots answers could not be considered "harmful", an…
View article: Evaluation of clinical outcome and predictive factors for thromboembolism or hemorrhagic complications in patients treated for chronic subdural hematoma. A prospective observational study
Evaluation of clinical outcome and predictive factors for thromboembolism or hemorrhagic complications in patients treated for chronic subdural hematoma. A prospective observational study Open
The impact of anticoagulant and antiplatelet medications on clinical outcome and risk of complications is uncertain in chronic subdural hematoma (CSDH) patients. Currently, evidence-based guidelines and specific neurosurgical scores lacks.…
View article: The Effectiveness of Four Quadrivalent, Inactivated Influenza Vaccines Administered Alone or in Combination with Pneumococcal and/or SARS-CoV-2 Vaccines: A Population-Wide Cohort Study
The Effectiveness of Four Quadrivalent, Inactivated Influenza Vaccines Administered Alone or in Combination with Pneumococcal and/or SARS-CoV-2 Vaccines: A Population-Wide Cohort Study Open
Background: Several influenza vaccine formulations are available, including adjuvanted, high-dose, trivalent, and quadrivalent vaccines, and direct, comparative evidence on the relative effectiveness is limited. Real-life data on the poten…
View article: Blood phosphorylated Tau217 distinguishes amyloid-positive from amyloid-negative subjects in the Alzheimer's disease continuum. A systematic review and meta-analysis
Blood phosphorylated Tau217 distinguishes amyloid-positive from amyloid-negative subjects in the Alzheimer's disease continuum. A systematic review and meta-analysis Open
View article: Influenza vaccination hesitancy and related factors among pregnant and breastfeeding women: A cross-sectional study
Influenza vaccination hesitancy and related factors among pregnant and breastfeeding women: A cross-sectional study Open
Achieving safe influenza vaccination coverage among pregnant and breastfeeding women is a global health goal due to the potential risks of serious influenza for both mother and child. However, vaccine hesitancy remains a significant barrie…
View article: COVID-19 vaccination, all-cause mortality, and hospitalization for cancer: 30-month cohort study in an Italian province
COVID-19 vaccination, all-cause mortality, and hospitalization for cancer: 30-month cohort study in an Italian province Open
Anecdotal reports suggested an association between SARS-CoV-2 vaccination and some cancers, but no formal assessment has been published. This population-wide cohort analysis was aimed at evaluating the risk of all-cause death and cancer ho…
View article: Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis
Blood phosphorylated Tau181 reliably differentiates amyloid‐positive from amyloid‐negative subjects in the Alzheimer's disease continuum: A systematic review and meta‐analysis Open
INTRODUCTION Blood‐based biomarkers seem promising for the diagnosis of Alzheimer's disease (AD). METHODS We performed a systematic review and meta‐analysis on the potential of blood phosphorylated Tau181 (p‐tau181) to differentiate amyloi…
View article: Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy.
Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy. Open
Background Decompressive craniectomy (DC) is a critical surgical intervention for elevated intracranial pressure. However, the impact of preoperative antiplatelet or anticoagulant therapy on outcomes and complications remains unclear. Meth…
View article: Immunogenicity and Safety of Chikungunya Vaccines: A Systematic Review and Meta-Analysis
Immunogenicity and Safety of Chikungunya Vaccines: A Systematic Review and Meta-Analysis Open
Several vaccines against chikungunya fever have been developed and tested, and one has been recently licensed. We performed a meta-analysis to estimate the immunogenicity and safety of all chikungunya vaccines that have been progressed to …
View article: Chronobiological variation in takotsubo syndrome: an updated systematic review and meta-analysis
Chronobiological variation in takotsubo syndrome: an updated systematic review and meta-analysis Open
View article: Real-Life Comparative Effectiveness of IL-23 Inhibitors in the Treatment of Moderate to Severe Psoriasis: A Multicenter Experience
Real-Life Comparative Effectiveness of IL-23 Inhibitors in the Treatment of Moderate to Severe Psoriasis: A Multicenter Experience Open
With the aim of assessing and comparing IL23 inhibitors’ effectiveness, safety and drug survival in a real life setting, we performed a retrospective study involving all psoriasis centers of Emilia Romagna, northern Italy.
View article: How strong is the evidence supporting the <scp>WHO</scp> guidelines on physical activity, sedentary behaviour and sleep in early childhood?
How strong is the evidence supporting the <span>WHO</span> guidelines on physical activity, sedentary behaviour and sleep in early childhood? Open
Background The WHO issued recommendations about the ideal amount of physical activity, sedentary behaviour and sleep in infants, toddlers and preschool children. To facilitate their interpretation and translation into public health policie…
View article: Factors Influencing COVID-19 Vaccine Hesitancy in Pregnant and Breastfeeding/Puerperium Women: A Cross-Sectional Study
Factors Influencing COVID-19 Vaccine Hesitancy in Pregnant and Breastfeeding/Puerperium Women: A Cross-Sectional Study Open
Vaccination among pregnant and breastfeeding women is critical for protecting this vulnerable population and their children. COVID-19 vaccination is recommended both during pregnancy and breastfeeding; however, we still do not fully unders…
View article: Immunogenicity, Safety and Efficacy of the Dengue Vaccine TAK-003: A Meta-Analysis
Immunogenicity, Safety and Efficacy of the Dengue Vaccine TAK-003: A Meta-Analysis Open
The TAK-003 dengue vaccine was licensed in Europe in December 2022, and the official recommendations from most EU countries are still under formulation. To support policymakers, we performed a meta-analysis to quantify TAK-003’s immunogeni…
View article: Author response to: Comment on: Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study
Author response to: Comment on: Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study Open
View article: Effectiveness of tailored talks between a cancer screening specialist and general practitioners to improve the uptake of colorectal cancer screening in Ancona (Italy) during the pandemic period
Effectiveness of tailored talks between a cancer screening specialist and general practitioners to improve the uptake of colorectal cancer screening in Ancona (Italy) during the pandemic period Open
Persons cared for by GPs who received a tailored talk with a cancer screening specialist avoided a drop in CRC screening adherence, which characterised all other Italian screening programmes during the COVID-19 emergency. If future randomi…
View article: Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients
Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients Open
View article: Impact of the Italian Healthcare Outcomes Program (PNE) on the Care Quality of the Poorest Performing Hospitals
Impact of the Italian Healthcare Outcomes Program (PNE) on the Care Quality of the Poorest Performing Hospitals Open
One of the main aims of the Italian National Healthcare Outcomes Program (Programma Nazionale Esiti, PNE) is the identification of the hospitals with the lowest performance, leading them to improve their quality. In order to evaluate PNE i…
View article: Effects of a sphenopalatine ganglion block on postcraniotomy pain management: a randomized, double-blind, clinical trial
Effects of a sphenopalatine ganglion block on postcraniotomy pain management: a randomized, double-blind, clinical trial Open
OBJECTIVE Postcraniotomy pain (PCP) is a common finding after neurosurgical procedures, occurring in as many 87% of patients. The sphenopalatine ganglion (SPG) has a pivotal role in several headache syndromes, and its anesthetic block is c…
View article: Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study
Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study Open
Background The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications…
View article: Chronic Obstructive Pulmonary Disease Overdiagnosis and Overtreatment: A Meta-Analysis
Chronic Obstructive Pulmonary Disease Overdiagnosis and Overtreatment: A Meta-Analysis Open
This meta-analysis of observational studies aimed at estimating the overall prevalence of overdiagnosis and overtreatment in subjects with a clinical diagnosis of Chronic Obstructive Pulmonary Disease (COPD). MedLine, Scopus, Embase and Co…
View article: Developing a Strategy for COVID-19 Control Among Hard-to-Reach Migrant Communities: The Experience of Roma 2 Local Health Authority
Developing a Strategy for COVID-19 Control Among Hard-to-Reach Migrant Communities: The Experience of Roma 2 Local Health Authority Open
Roma 2 Local Health Authority (ASL) developed a strategy to control the COVID-19 epidemic in Hard-to-reach (HTR) migrant communities, addressing both the containment of clusters in informal settlements and access to COVID-19 vaccination. T…