Maria Elisa Giuliani
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View article: Mechanisms of Cellular Responses of the Natural Alkaloid Caulerpin and Its Similarities with the Lipid-Lowering Agent Fenofibrate in Mytilus galloprovincialis
Mechanisms of Cellular Responses of the Natural Alkaloid Caulerpin and Its Similarities with the Lipid-Lowering Agent Fenofibrate in Mytilus galloprovincialis Open
Marine-derived natural products have attracted increasing attention due to their promising pharmacological potential against various diseases. The present study investigated the hypolipidemic properties of the alkaloid caulerpin, a seconda…
View article: A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice
A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice Open
Background Grip strength is a key functional marker of musculoskeletal aging, widely used to assess sarcopenia. In preclinical research, multiple measurement methods are often combined to enhance reliability, but standardization remains ch…
View article: The aging choroid plexus and its relationship with gut dysbiosis and Klotho decline: possible intervention strategies
The aging choroid plexus and its relationship with gut dysbiosis and Klotho decline: possible intervention strategies Open
View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the article A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties by Sandra Atlante et al., https://doi.org/10.1111/acel.70047. [Image: see text]
View article: A Novel Cognitive Frailty Index for Geriatric Mice
A Novel Cognitive Frailty Index for Geriatric Mice Open
Loss of cognitive function is a significant challenge in aging, and developing models to understand and target cognitive decline is crucial for the development of Geroscience‐based interventions. Aged mice offer a valuable model as they sh…
View article: A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties Open
The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents—compounds that selectively eliminate senescent cells—is a critical priority. Heat shock protein 90 (HSP90) inhibito…
View article: Integrative oxidative stress biomarkers in gills and digestive gland of the combined exposure to citalopram and bezafibrate with polyethylene microplastics on mussels Mytilus galloprovincialis
Integrative oxidative stress biomarkers in gills and digestive gland of the combined exposure to citalopram and bezafibrate with polyethylene microplastics on mussels Mytilus galloprovincialis Open
View article: Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery
Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery Open
Major depressive disorder (MDD) is a severe psychiatric condition that significantly impacts the overall quality of life. Although MDD can occur across all age groups, it is notably prevalent among older individuals, with the aggravating c…
View article: Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes
Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes Open
Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to …
View article: Subcellular effects and lipid metabolism alterations in the gilthead seabream Sparus aurata fed on ovatoxins-contaminated mussels.
Subcellular effects and lipid metabolism alterations in the gilthead seabream Sparus aurata fed on ovatoxins-contaminated mussels. Open
View article: Integrative Oxidative Stress Biomarkers in Gills and Digestive Gland of the Combined Exposure to Citalopram and Bezafibrate with Polyethylene Microplastics on Mussels Mytilus Galloprovincialis
Integrative Oxidative Stress Biomarkers in Gills and Digestive Gland of the Combined Exposure to Citalopram and Bezafibrate with Polyethylene Microplastics on Mussels Mytilus Galloprovincialis Open
View article: Cellular senescence and frailty: a comprehensive insight into the causal links
Cellular senescence and frailty: a comprehensive insight into the causal links Open
View article: Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty
Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty Open
The spreading of senescent cells’ burden holds profound implications for frailty, prompting the exploration of novel therapeutic targets. In this perspective review, we delve into the intricate mechanisms underlying senescent cell spreadin…
View article: Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice
Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice Open
The homozygous genotype of the Longevity-Associated Variant (LAV) in Bactericidal/Permeability-Increasing Fold-Containing Family B member 4 (BPIFB4) is enriched in long-living individuals of three independent populations and its genetic tr…
View article: Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice
Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice Open
View article: Toxicological effects of cigarette butts for marine organisms
Toxicological effects of cigarette butts for marine organisms Open
Cigarette butts (CBs), one of the most common litter items found on beaches, represent a still unexplored environmental hazard. This study aimed at a multidisciplinary characterization of their toxicological risks on marine organisms integ…
View article: Trophic Transfer and Subcellular Effects of Ovatoxins in the Gilthead Seabream Sparus Aurata: A Focus on Lipid Metabolism Alterations
Trophic Transfer and Subcellular Effects of Ovatoxins in the Gilthead Seabream Sparus Aurata: A Focus on Lipid Metabolism Alterations Open
View article: Application of a Multidisciplinary Weight of Evidence Approach as a Tool for Monitoring the Ecological Risk of Dredging Activities
Application of a Multidisciplinary Weight of Evidence Approach as a Tool for Monitoring the Ecological Risk of Dredging Activities Open
The use of multidisciplinary investigations for the evaluation of aquatic ecosystems status is recommended by the European Directives, but it is still a challenging practice. In this study, we apply a quantitative weight of evidence (WOE) …
View article: Emerging environmental stressors and oxidative pathways in marine organisms: Current knowledge on regulation mechanisms and functional effects
Emerging environmental stressors and oxidative pathways in marine organisms: Current knowledge on regulation mechanisms and functional effects Open
Oxidative stress is a critical condition derived from the imbalance between the generation of reactive oxygen species and the sophisticated network of antioxidant mechanisms. Several pollutants and environmental factors can affect this sys…
View article: Tetrodotoxins (TTXs) and Vibrio alginolyticus in Mussels from Central Adriatic Sea (Italy): Are They Closely Related?
Tetrodotoxins (TTXs) and Vibrio alginolyticus in Mussels from Central Adriatic Sea (Italy): Are They Closely Related? Open
Tetrodotoxins (TTXs), potent neurotoxins, have become an increasing concern in Europe in recent decades, especially because of their presence in mollusks. The European Food Safety Authority published a Scientific Opinion setting a recommen…
View article: Transcriptional and Catalytic Responsiveness of the Antarctic Fish Trematomus bernacchii Antioxidant System toward Multiple Stressors
Transcriptional and Catalytic Responsiveness of the Antarctic Fish Trematomus bernacchii Antioxidant System toward Multiple Stressors Open
Ocean-warming and acidification jeopardize Antarctic marine species, adapted to cold and constant conditions and naturally exposed to high pro-oxidant pressures and cadmium (Cd) bioavailability. The aim of this study was to investigate if …
View article: Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems
Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems Open
Background The display of recombinant proteins on cell surfaces has a plethora of applications including vaccine development, screening of peptide libraries, whole-cell biocatalysts and biosensor development for diagnostic, industrial or e…
View article: Additional file 1 of Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems
Additional file 1 of Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems Open
Additional file 1: Table S1. List of primers used in this study.
View article: Additional file 3 of Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems
Additional file 3 of Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems Open
Additional file 3: Table S2. List of expression plasmids used in this study.
View article: 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents
4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents Open
View article: Omics approaches for conservation biology research on the bivalve Chamelea gallina
Omics approaches for conservation biology research on the bivalve Chamelea gallina Open
The striped venus ( Chamelea gallina ) is an important economic resource in the Mediterranean Basin; this species has exhibited a strong quantitative decline in the Adriatic Sea. The aim of this work was to provide a comprehensive view of …
View article: Decorating the Surface of Escherichia Coli with Bacterial Lipoproteins: A Comparative Analysis of Different Display Systems
Decorating the Surface of Escherichia Coli with Bacterial Lipoproteins: A Comparative Analysis of Different Display Systems Open
Background: The display of recombinant proteins on cell surfaces has a plethora of applications including vaccine development, screening of peptide libraries, whole-cell biocatalysts and biosensor development for diagnostic, industrial or …
View article: Multicomponent meningococcal serogroup B vaccination elicits cross-reactive immunity in infants against genetically diverse serogroup C, W and Y invasive disease isolates
Multicomponent meningococcal serogroup B vaccination elicits cross-reactive immunity in infants against genetically diverse serogroup C, W and Y invasive disease isolates Open
This is the first study in which 147 non-MenB serogroup isolates have been analysed in hSBA to evaluate the potential of a MenB vaccine to cover strains belonging to other serogroups. These data demonstrate that antibodies raised by 4CMenB…
View article: Genomic Characterization of Invasive Meningococcal Serogroup B Isolates and Estimation of 4CMenB Vaccine Coverage in Finland
Genomic Characterization of Invasive Meningococcal Serogroup B Isolates and Estimation of 4CMenB Vaccine Coverage in Finland Open
4CMenB is a 4-component vaccine used against invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup B (MenB). We investigated the genetic variability of MenB in Finland and evaluated 4CMenB strain coverage by 2 dif…
View article: Season specific influence of projected ocean changes on the response to cadmium of stress-related genes in Mytilus galloprovincialis
Season specific influence of projected ocean changes on the response to cadmium of stress-related genes in Mytilus galloprovincialis Open