Maria Elisabeth Street
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View article: Challenges in assessing bone health in early infancy: a narrative review of existing technologies
Challenges in assessing bone health in early infancy: a narrative review of existing technologies Open
To date, no shared guidelines have been approved for the diagnosis and management of low bone mineral density (BMD), especially in early infancy. Therefore, there is an increasing demand for new methodologies to allow the assessment of bon…
View article: Multidisciplinary Treatment of Patients With Noonan Syndrome
Multidisciplinary Treatment of Patients With Noonan Syndrome Open
Importance Noonan syndrome (NS) is a rare developmental disorder and the most common condition among the RASopathies. Diagnosis and treatment of NS can be challenging due to the wide phenotypic variability of its manifestations. A multidis…
View article: EndoCompass project: environmental endocrinology
EndoCompass project: environmental endocrinology Open
Background Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal i…
View article: Perinatal oxidative stress and bone development in the first year of life: A preliminary study using REMS
Perinatal oxidative stress and bone development in the first year of life: A preliminary study using REMS Open
Background: Oxidative stress has been implicated in impairing tissue development, but its impact on early postnatal skeletal growth in humans remains poorly understood. This study investigates the relationship between perinatal redox statu…
View article: Early bone health: exploring relationship between oxidative stress and skeletal development in newborn infants
Early bone health: exploring relationship between oxidative stress and skeletal development in newborn infants Open
Bone health during childhood is critical for proper skeletal development and long-term quality of life. The process of bone formation relies on a balance of mineralization and cellular activity, which is regulated by oxidative stress (OS).…
View article: Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies
Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies Open
Childhood obesity is a growing global health concern, with established links to physical activity, nutrition, and, increasingly, to prenatal and perinatal factors. Emerging evidence highlights the significant role of maternal conditions su…
View article: Beyond Muscle Weakness: Unraveling Endocrine and Metabolic Dysfunctions in Duchenne Muscular Dystrophy, a Narrative Review
Beyond Muscle Weakness: Unraveling Endocrine and Metabolic Dysfunctions in Duchenne Muscular Dystrophy, a Narrative Review Open
Background: Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder caused by mutations in the DMD gene, leading to progressive muscle degeneration, loss of ambulation, and multi-systemic complications. Beyond its imp…
View article: Changes in Coping Strategies of Parents and Girls with Central Precocious Puberty Before and After the COVID-19 Lockdown: Data from Four Italian Pediatric Endocrinology Centers
Changes in Coping Strategies of Parents and Girls with Central Precocious Puberty Before and After the COVID-19 Lockdown: Data from Four Italian Pediatric Endocrinology Centers Open
The increased stress during the COVID-19 pandemic may have influenced the coping strategies used by children and parents who adapted to a diagnosis of central precocious puberty (CPP). This study aimed to explore whether the coping mechani…
View article: Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone)
Radiofrequency echographic multi-spectrometry for early bone health: The REMS-bone study protocol (Trial acronym: REMS-bone) Open
View article: Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic review
Use of gonadotropin-releasing hormone agonists in transgender and gender diverse youth: a systematic review Open
Introduction Puberty suppression using gonadotropin-releasing hormone agonists (GnRHa) is a reversible medical intervention that halts endogenous puberty, allowing transgender and gender-diverse (TGD) adolescents to avoid the development o…
View article: The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 1: Metabolic Changes
The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 1: Metabolic Changes Open
Childhood obesity is a growing global health issue. Its rising prevalence is linked to genetic, environmental, and lifestyle factors. Obesity in children could lead to different comorbidities and complications with an increased risk of met…
View article: Acute Suppurative and Subacute Thyroiditis: From Diagnosis to Management
Acute Suppurative and Subacute Thyroiditis: From Diagnosis to Management Open
Background: Acute suppurative thyroiditis (AST) and subacute thyroiditis (SAT) are two distinct inflammatory conditions of the thyroid gland with different clinical presentation and treatment and that recognize different causes. AST is a r…
View article: The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 2: Comorbidities
The Role of Nutraceuticals and Probiotics in Addition to Lifestyle Intervention in the Management of Childhood Obesity—Part 2: Comorbidities Open
Pediatric obesity is associated with a wide range of comorbidities beyond metabolic changes, affecting cardiovascular, endocrine, reproductive, musculoskeletal systems, and also mental health. Hypertension, commonly observed in children wi…
View article: Various sexual identities among a cohort of Italian adolescents: from their own perception of selves to social and healthcare acceptance
Various sexual identities among a cohort of Italian adolescents: from their own perception of selves to social and healthcare acceptance Open
Background: Gender incongruence (GI) is the conflict between the sex assigned at birth and the perceived gender identity, sometimes leading to significant distress (gender dysphoria). The WPATH Standards of Care (SOC) estimate that transge…
View article: An analysis of real-life data of infants born to mothers with autoimmune thyroiditis: do they need to be followed-up?
An analysis of real-life data of infants born to mothers with autoimmune thyroiditis: do they need to be followed-up? Open
View article: Landscape of paediatric endocrine clinical practice in Italy: results from a survey of the Italian Society for Paediatric Endocrinology and Diabetology (ISPED)
Landscape of paediatric endocrine clinical practice in Italy: results from a survey of the Italian Society for Paediatric Endocrinology and Diabetology (ISPED) Open
Background Pediatric endocrinology has developed enormously over the last 30 years. Many conditions followed-up are rare and/or chronic complex diseases requiring a high level of expertise. Therefore, defining pediatric endocrinology workf…
View article: Acute Suppurative and Subacute Thyroiditis: from Diagnosis to Management
Acute Suppurative and Subacute Thyroiditis: from Diagnosis to Management Open
Background: Acute Suppurative Thyroiditis (AST) and Subacute Thyroiditis (SAT) are two distinct inflammatory conditions of the thyroid gland with different clinical presentation, treatment and that recognize different causes. AST is a rare…
View article: Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data
Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data Open
Context There has been concern about a potential increase in the incidence or severity of coronavirus disease 2019 (COVID-19) in individuals with adrenal insufficiency (AI). Data on the course of SARS-CoV-2 infection in AI children are lac…
View article: Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study
Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study Open
Background The aim of the study was to explore a radiomic model that could assist physicians in the diagnosis of central precocious puberty (CPP). A predictive model based on radiomic features (RFs), extracted form magnetic resonance imagi…
View article: Correction to: Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope®) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study
Correction to: Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope®) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study Open
View article: Systematic review on Endocrine Disrupting Chemicals in breastmilk and neuro-behavioral development: Insight into the early ages of life
Systematic review on Endocrine Disrupting Chemicals in breastmilk and neuro-behavioral development: Insight into the early ages of life Open
Breast milk (BM) is the main nutrition source for infants that plays a key role on growth and development. Human milk composition includes endogenous and exogenous substances, including endocrine disrupting chemicals (EDCs). EDCs are man-m…
View article: The impact of telemedicine on pediatric type 1 diabetes management: benefits, challenges, and future directions
The impact of telemedicine on pediatric type 1 diabetes management: benefits, challenges, and future directions Open
Telemedicine (TM) has emerged as a valuable tool in managing pediatric type 1 diabetes (T1D), particularly during the COVID-19 pandemic when traditional in-person visits were limited. This narrative review examines the impact of TM on pati…
View article: Insights into pubertal development: a narrative review on the role of epigenetics
Insights into pubertal development: a narrative review on the role of epigenetics Open
Purpose Puberty is a key phase of growth and development, characterized by psychophysical transformations. It is driven by a combination of genetic, hormonal, and environmental variables. Epigenetic mechanisms, including histone post-trans…
View article: Telemedicine for Managing Type 1 Diabetes in Children and Adolescents Before and After the COVID-19 Pandemic
Telemedicine for Managing Type 1 Diabetes in Children and Adolescents Before and After the COVID-19 Pandemic Open
The COVID-19 pandemic has catalyzed the rapid expansion of telemedicine for managing chronic conditions such as type 1 diabetes (T1D) in children and adolescents. This narrative review aims to explore the role of telemedicine in pediatric …
View article: Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope®) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study
Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope®) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study Open
This final analysis extends the interim analysis findings from the PATRO Children study and confirms the long-term safety and effectiveness of Omnitrope® in Italian pediatric patients with growth disturbances.
View article: Study of Endocrine-Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE-MILCH PROJECT
Study of Endocrine-Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE-MILCH PROJECT Open
Exposure to endocrine-disrupting chemicals (EDCs) is inevitable, and growing scientific evidence indicates that even very low doses can negatively impact human health, particularly during pregnancy and the neonatal period. As part of the E…
View article: Study of Endocrine Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE‐MILCH PROJECT
Study of Endocrine Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE‐MILCH PROJECT Open
Exposure to endocrine-disrupting chemicals (EDCs) is inevitable, and growing scientific evidence indicates that even very low doses can negatively impact human health, particularly during pregnancy and the neonatal period. As part of the E…
View article: Cardiometabolic risk in children and adolescents with obesity: a position paper of the Italian Society for Pediatric Endocrinology and Diabetology
Cardiometabolic risk in children and adolescents with obesity: a position paper of the Italian Society for Pediatric Endocrinology and Diabetology Open
View article: Which is the current knowledge on man-made endocrine- disrupting chemicals in follicular fluid? An overview of effects on ovarian function and reproductive health
Which is the current knowledge on man-made endocrine- disrupting chemicals in follicular fluid? An overview of effects on ovarian function and reproductive health Open
The increase in female reproductive disorders, such as polycystic ovary syndrome, endometriosis, and diminished ovarian reserve that lead to subfertility and infertility, has encouraged researchers to search and discover their underlying c…
View article: Osteoporosis and Bone Fragility in Children: Diagnostic and Treatment Strategies
Osteoporosis and Bone Fragility in Children: Diagnostic and Treatment Strategies Open
The incidence of osteoporosis in children is increasing because of the increased survival rate of children with chronic diseases and the increased use of bone-damaging drugs. As childhood bone fragility has several etiologies, its manageme…