Maria Eugénia Marques Da Costa
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View article: Valorization of pumpkin-seed press-cake and hulls from agri-food waste streams
Valorization of pumpkin-seed press-cake and hulls from agri-food waste streams Open
View article: Harnessing Insects as Novel Food Ingredients: Nutritional, Functional, and Processing Perspectives
Harnessing Insects as Novel Food Ingredients: Nutritional, Functional, and Processing Perspectives Open
The rising demand for sustainable protein is driving interest in insects as a raw material for advanced food ingredients. This review collates and critically analyses over 300 studies on the conversion of crickets, mealworms, black soldier…
View article: Targeting metastasis in paediatric bone sarcomas
Targeting metastasis in paediatric bone sarcomas Open
View article: Kidney Outcomes in Children with Posterior Urethral Valves
Kidney Outcomes in Children with Posterior Urethral Valves Open
View article: Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy
Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy Open
Oncogenic metabolism depends on multifaceted mechanisms, including bidirectional inter-organelle communication between mitochondria and the nucleus, facilitating cellular adaptation at the transcriptomic, proteomic, and metabolomic levels.…
View article: Leveraging quantitative structure-activity relationships to design and optimize wall material formulations for antioxidant encapsulation via spray drying
Leveraging quantitative structure-activity relationships to design and optimize wall material formulations for antioxidant encapsulation via spray drying Open
This study addresses the critical challenge of optimizing antioxidant encapsulation to enhance stability and bioavailability during spray drying. To address this, the research integrates quantitative structure–activity relationship (QSAR) …
View article: SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types
SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types Open
Epigenetic modifications, which reversibly regulate gene expression without altering the DNA sequence, are increasingly described in the literature as essential elements in the processes leading to cancer development. SETDB1 regulates hist…
View article: Endometriose e qualidade de vida: impacto do cotidiano da mulher
Endometriose e qualidade de vida: impacto do cotidiano da mulher Open
View article: Functional profile of patients with heart failure followed up in a referral ambulatory in southern Brazil
Functional profile of patients with heart failure followed up in a referral ambulatory in southern Brazil Open
Heart failure (HF) is a complex clinical syndrome, and its prevalence has been increasing in recent years. Despite advancements in pharmacological therapy, symptoms such as fatigue, dyspnea, and exercise intolerance are still likely to per…
View article: Figure S7 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S7 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
CosMx 64-plex human immuno-oncology protein panel
View article: Figure S4 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S4 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Performances of the deep-learning cell detection model in TCGA cohorts (oral cavity, uterine cervix and larynx SCC) and GR cohorts (oral cavity SCC)
View article: Figure S10 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S10 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Agreement between two pathologists
View article: Supplementary Table S9 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Supplementary Table S9 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
This table provides the DEG between MGC spots and non-MGC spots
View article: Supplementary Video S2 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Supplementary Video S2 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Representative video of granulomas made of multiple MGC in oral cavity SCC from GR cohort
View article: Figure S6 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S6 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Immunohistochemistry for representative Visium markers
View article: Figure S1 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S1 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Association between keratin, MGC and clinical outcome
View article: Figure S5 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S5 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Supervised MGC signature
View article: Supplementary Table S8 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Supplementary Table S8 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
This table provides the DEG for the seven main clusters of the Visium experiment
View article: Figure S8 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S8 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
CosMx protein panel showing stainings in MGC
View article: Supplementary Video S1 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Supplementary Video S1 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Representative video of an isolated MGC in oral cavity SCC from GR cohort
View article: Supplementary Tables S1 to S7 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Supplementary Tables S1 to S7 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Clinical Tables and Statistical Analyses
View article: Data from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Data from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Patients with head and neck squamous cell carcinomas (HNSCC) often have poor outcomes due to suboptimal risk management and treatment strategies; yet integrating novel prognostic biomarkers into clinical practice is challenging. Here, we r…
View article: Figure S9 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S9 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Microscopic visualization of MGC
View article: Figure S2 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S2 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Quantification of TILs, CD68-positive mononuclear macrophages and tumor grade
View article: Figure S3 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Figure S3 from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Pathological response to induction chemotherapy
View article: Supplementary Videos Legends from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
Supplementary Videos Legends from TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Legends of the two videos S1 and S2
View article: Data-Driven R&D&I Management for Societal Impacts: Introduction and Application of AgroRadarEval
Data-Driven R&D&I Management for Societal Impacts: Introduction and Application of AgroRadarEval Open
Recognizing evaluation results as a crucial source of information to support RD&I management, this article introduces 'AgroRadarEval', an interactive tool aimed at fulfilling theoretical, conceptual, and practical gaps concerning the syste…
View article: Probiotication of Plum Pulp and Conditions Effects Freeze-Drying in Cell Viability, Functional Properties and Antioxidant Activity
Probiotication of Plum Pulp and Conditions Effects Freeze-Drying in Cell Viability, Functional Properties and Antioxidant Activity Open
This study investigated the effects of fermenting plum pulp with Bifidobacterium animalis ssp. lactis (BAL) on its physicochemical and bioactive properties, as well as the optimization of the freeze-drying (FD) process to develop a fruit-b…
View article: TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma
TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma Open
Patients with head and neck squamous cell carcinomas (HNSCC) often have poor outcomes due to suboptimal risk management and treatment strategies; yet integrating novel prognostic biomarkers into clinical practice is challenging. Here, we r…
View article: Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs
Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs Open