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View article: Dexamethasone, Rituximab and Cyclophosphamide with Bortezomib is a rapidly acting and highly efficient first-line treatment in Waldenström's Macroglobulinemia: Final analysis of ECWM-1 trial of the European Consortium for Waldenström's Macroglobulinemia (ECWM)
Dexamethasone, Rituximab and Cyclophosphamide with Bortezomib is a rapidly acting and highly efficient first-line treatment in Waldenström's Macroglobulinemia: Final analysis of ECWM-1 trial of the European Consortium for Waldenström's Macroglobulinemia (ECWM) Open
Beside Rituximab-Bendamustine, the Dexamethasone, Rituximab and Cyclophospamide (DRC) regimen is still one of the most frequently used first-line treatments for patients with Waldenström's Macroglobulinemia (WM). It was originally reported…
View article: Prognostic impact of specific IGHV rearrangements in younger untreated Mantle Cell Lymphoma patients is independent of p53 alterations and may be modified by ibrutinib-based regimens: Insights from the TRIANGLE trial within the MULTIPLY project
Prognostic impact of specific IGHV rearrangements in younger untreated Mantle Cell Lymphoma patients is independent of p53 alterations and may be modified by ibrutinib-based regimens: Insights from the TRIANGLE trial within the MULTIPLY project Open
Introduction The TRIANGLE trial (Dreyling et al, Lancet 2024) compared three treatment arms in untreated, younger patients with mantle cell lymphoma (MCL): arm I (IR-CHOP/R-DHAP + ibrutinib maintenance [Im]), arm A+I (IR-CHOP/R-DHAP + ASCT…
View article: Metabolomic Profiling of Citrus Grafts Challenged by <i>Phytophthora citrophthora</i> : Using the Same Samples Previously Analyzed for Epigenetic Responses
Metabolomic Profiling of Citrus Grafts Challenged by <i>Phytophthora citrophthora</i> : Using the Same Samples Previously Analyzed for Epigenetic Responses Open
Phytophthora citrophthora infection severely affects citrus crops, demanding improved diagnostic and control strategies. In a previous study, epigenetic responses, including DNA methylation patterns, were analyzed in grafted citrus plants …
View article: Development of Xanthyletin-Loaded Nanoparticles for the Control of Leucoagaricus gongylophorus
Development of Xanthyletin-Loaded Nanoparticles for the Control of Leucoagaricus gongylophorus Open
This study describes the development, characterization and in vitro evaluation of poly(ε-caprolactone) (PCL) nanoparticles loaded with xanthyletin for the control of Atta sexdens rubropilosa through the inhibition of its symbiotic fungus L…
View article: Selective Native N<sub>(in)</sub>–H Bond Activation in Peptides with Metallaphotocatalysis
Selective Native N<sub>(in)</sub>–H Bond Activation in Peptides with Metallaphotocatalysis Open
The development of chemical methods enabling site-selective incorporation of noncanonical amino acids into peptide backbones with precise functional tailoring remains a critical challenge. Particularly compelling is the use of underexplore…
View article: Green Extraction and NMR Analysis of Bioactives from Orange Juice Waste
Green Extraction and NMR Analysis of Bioactives from Orange Juice Waste Open
Brazil is a global leader in the orange industry, producing approximately one-fourth of the world’s oranges and generating over 50% of the associated waste. These by-products are rich in bioactive compounds; however, their improper disposa…
View article: Chemical Compounds from Ocotea neesiana (Miq.) Kosterm Demolition Wood and Their Effect on the Growth of Xanthomonas citri subsp. citri
Chemical Compounds from Ocotea neesiana (Miq.) Kosterm Demolition Wood and Their Effect on the Growth of Xanthomonas citri subsp. citri Open
Citrus canker is a bacterial disease that is caused by Xanthomonas citri subsp. citri (Xcc) and affects all commercially important Citrus species. In this paper, we report a phytochemical study of Ocotea neesiana demolition wood, and the a…
View article: Chemistry in the Service of Dengue Protection
Chemistry in the Service of Dengue Protection Open
Dengue fever, a mosquito-borne disease caused by the dengue virus, is a major public health concern worldwide. With no specific treatment or widely available vaccine, prevention is key. This is where chemistry steps in, offering solutions …
View article: Antioxidant activity of an Mg(<scp>ii</scp>) compound containing ferulic acid as a chelator: potential application for active packaging and riboflavin stabilisation
Antioxidant activity of an Mg(<span>ii</span>) compound containing ferulic acid as a chelator: potential application for active packaging and riboflavin stabilisation Open
A novel Mg( ii )-based antioxidant with high electrochemical stabilization and enhanced antioxidant activity. The complex is able to stabilize and protect Rf from photodegradation and showed antimicrobial effect enabling its use for meat p…
View article: Biodegradation of the Antibiotic Doxycycline by Bacteria from the Gastrointestinal Tract of Cucurbit Beetles (Diabrotica speciosa)
Biodegradation of the Antibiotic Doxycycline by Bacteria from the Gastrointestinal Tract of Cucurbit Beetles (Diabrotica speciosa) Open
Antibiotics can contaminate the environment as a result of improper disposal. The induction of doxycycline in the environment could give rise to lineages of the cucurbit beetle Diabrotica speciosa containing resistant endosymbiotic microor…
View article: Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking
Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking Open
Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its leaves are valued for their high content of phragmalin-type limonoids, a subclass of…
View article: Multicomponent Reactions Promoted by Ecocatalyst from Metal Hyperaccumulating Plant Pluchea sagittalis
Multicomponent Reactions Promoted by Ecocatalyst from Metal Hyperaccumulating Plant Pluchea sagittalis Open
Phytoremediation has been considered a sustainable environmental technology for heavy metals decontamination. In this work, we evaluated the metal contents by inductively coupled plasma optical emission spectrometry (ICP-OES) of three plan…
View article: Occurrence of Multiple Glyphosate-Resistant Weeds in Brazilian Citrus Orchards
Occurrence of Multiple Glyphosate-Resistant Weeds in Brazilian Citrus Orchards Open
Glyphosate is the most widely used herbicide for weed control in citrus orchards in Brazil; therefore, it is likely that several species have gained resistance to this herbicide and that more than one resistant species can be found in the …
View article: Herbicide resistance status of sourgrass
Herbicide resistance status of sourgrass Open
Sourgrass [ Digitaria insularis (L.) Mez ex Ekman] is one of the most challenging herbicide-resistant weeds in the grain-producing areas of Southeast, Central-west, and Northeast of Brazil. This species is a perennial grass that is highly …
View article: MALDI-TOF Mass Spectrometry for the Diagnosis of Citrus Canker Caused by Xanthomonas citri subsp. citri
MALDI-TOF Mass Spectrometry for the Diagnosis of Citrus Canker Caused by Xanthomonas citri subsp. citri Open
Citrus canker, caused by the bacterium Xanthomonas citri subsp. citri (Xcc), is a disease that causes serious problems to the global citrus industry. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry …
View article: Exploring chemical diversity in Glycine max cultivars: A multivariate approach in the search for bioactive compounds against Spodoptera cosmioides
Exploring chemical diversity in Glycine max cultivars: A multivariate approach in the search for bioactive compounds against Spodoptera cosmioides Open
Soybean crop is regulated by abiotic and biotic stresses with great potential in reducing grain yield and quality. The selection of resistant cultivars is a promising approach for mitigating these damages. We evaluated the chemical profile…
View article: The Symbiotic Fungus Leucoagaricus gongylophorus (Möller) Singer (Agaricales, Agaricaceae) as a Target Organism to Control Leaf-Cutting Ants
The Symbiotic Fungus Leucoagaricus gongylophorus (Möller) Singer (Agaricales, Agaricaceae) as a Target Organism to Control Leaf-Cutting Ants Open
Atta and Acromyrmex are the main genera of leaf-cutting ants present in North and South America, causing extensive damage to agroforestry. Control of the ants requires high handling costs with few effective methods available to decrease th…
View article: SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals
SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals Open
There are large differences in the shape and size of regional SARS-CoV-2 epidemics in Brazil. Here we tested monthly blood donation samples for IgG antibodies from March 2020 to March 2021 in eight of Brazil’s most populous cities. There w…
View article: Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-As
Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-As Open
The aim of the current study was the valorization of hesperidin, the dominant flavonoid in citrus processing waste, by microwave-assisted synthesis of hesperidin-Mg complex, improving its antioxidant activity and insecticidal potential. He…
View article: Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-Assisted Synthesis of Hesperidin-Mg Complex and Their Insecticidal Activity
Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-Assisted Synthesis of Hesperidin-Mg Complex and Their Insecticidal Activity Open
The aim of the current study was the valorization of hesperidin, the dominant flavonoid in citrus processing waste, by microwave-assisted synthesis of hesperidin-Mg complex, improving its antioxidant activity and insecticidal potential. He…
View article: Quality Control for Lignin and Gelatin Microcapsules Loaded with Orange Essential Oil
Quality Control for Lignin and Gelatin Microcapsules Loaded with Orange Essential Oil Open
Sustainable natural product-based microstructured systems and biopolymers are strong candidates for use in crop protection. Lignin and gelatin microcapsules loaded with orange essential oil were developed with spray-drying in order to enha…
View article: Adoptive immunotherapy with double‐bright (CD56<sup>bright</sup>/CD16<sup>bright</sup>) expanded natural killer cells in patients with relapsed or refractory acute myeloid leukaemia: a proof‐of‐concept study
Adoptive immunotherapy with double‐bright (CD56<sup>bright</sup>/CD16<sup>bright</sup>) expanded natural killer cells in patients with relapsed or refractory acute myeloid leukaemia: a proof‐of‐concept study Open
Summary Patients with acute myeloid leukaemia (AML) have a five‐year survival rate of 28·7%. Natural killer (NK)‐cell have anti‐leukaemic activity. Here, we report on a series of 13 patients with high‐risk R/R AML, treated with repeated in…
View article: Encapsulation of B. bassiana in Biopolymers: Improving Microbiology of Insect Pest Control
Encapsulation of B. bassiana in Biopolymers: Improving Microbiology of Insect Pest Control Open
The fungus Beauveria bassiana is widely used for pest control; however, biostability and dispersion for broth pulverization are limiting factors for its application in the field. In this context, formulation techniques such as microencapsu…
View article: Historical Analysis of the Role of Governance Systems in the Sustainable Development of Biofuels in Brazil and the United States of America (USA)
Historical Analysis of the Role of Governance Systems in the Sustainable Development of Biofuels in Brazil and the United States of America (USA) Open
The United States of America and Brazil are the world’s first and second-largest biofuels producers. The United States (U.S.) has dedicated a significant portion of agricultural land for crops to produce biodiesel, while Brazil has been us…
View article: Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools
Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools Open
Anomalocalyx uleanus (Pax & K. Hoffm.) Ducke (Euphorbiaceae) is a singular species in the genus and is restricted and exclusive to the Brazilian Amazon. A phytochemical study of A. uleanus leaves was performed, yielding the isolation of fi…
View article: Flavonoids and Insecticidal Activity Against Spodoptera frugiperda of Myrsine coriacea (Primulaceae)
Flavonoids and Insecticidal Activity Against Spodoptera frugiperda of Myrsine coriacea (Primulaceae) Open
This study was conducted to evaluate the insecticidal effects of Myrsine coriacea (Primulaceae) against one of the main pests of maize, the fall armyworm (Spodoptera frugiperda), as well as performing the phytochemical study of M. coriacea…
View article: Evaluation of Lignins of Trunk and Roots from Citrus sinensis L. Osbeck: A Large Available Brazilian Biomass
Evaluation of Lignins of Trunk and Roots from Citrus sinensis L. Osbeck: A Large Available Brazilian Biomass Open
Citrus biomass is a source of biobased products and presents extensive chemical diversity. Among the structural macromolecules, lignins have been used in resins, bioplastics, and nanoencapsulation. Brazil has a large source of lignins, whi…