Maria G. Roubelakis
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View article: Putrescine functions as a metabolic checkpoint in replication stress-induced senescence
Putrescine functions as a metabolic checkpoint in replication stress-induced senescence Open
View article: A proteomics resource investigating fibrosis: proof-of-concept for identifying novel drug candidates
A proteomics resource investigating fibrosis: proof-of-concept for identifying novel drug candidates Open
View article: Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources
Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources Open
Mesenchymal Stromal/Stem Cells (MSCs) have attracted considerable attention in the field of regenerative medicine. Their unique properties make them suitable for various therapeutic applications. This article reviews accepted methods and g…
View article: Liver-Targeted Fetal MSC-Derived Extracellular Vesicles: A Therapeutic Approach in a Mouse Model of Acute Hepatic Failure
Liver-Targeted Fetal MSC-Derived Extracellular Vesicles: A Therapeutic Approach in a Mouse Model of Acute Hepatic Failure Open
BackgroundAcute hepatic failure (AHF) is a rapid deterioration of hepatocellular function, which includes coagulopathy and hepatic encephalopathy and it is related with high mortality rate. To date, liver replacement is the sole successful…
View article: A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations
A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations Open
Collagen type I (COL(I)) is a key component of the extracellular matrix (ECM) and is involved in cell signaling and migration through cell receptors. Collagen degradation produces bioactive peptides (matrikines), which influence cellular p…
View article: A naturally occurring urinary collagen type I alpha 1-derived peptide inhibits collagen type I-induced endothelial cell migration at physiological concentrations
A naturally occurring urinary collagen type I alpha 1-derived peptide inhibits collagen type I-induced endothelial cell migration at physiological concentrations Open
Collagen type I (COL(I)) is a key component of the extracellular matrix (ECM) and is involved in cell signalling and migration through cell receptors. Collagen degradation produces bioactive peptides (matrikines), which influence cellular …
View article: A proteomics resource investigating fibrosis: proof-of-concept for identifying novel drug candidates
A proteomics resource investigating fibrosis: proof-of-concept for identifying novel drug candidates Open
View article: Figure 6 from Repurposing Amiodarone for Bladder Cancer Treatment
Figure 6 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Amiodarone inhibits mTOR and MAPK pathways. Cells were treated for 24 hours with increasing concentrations of amiodarone (0, 12.5, and 25 μmol/L), and the expression of the proteins AKT, mTOR, S6, and p44/42 MAPK, both phosphorylated (p-) …
View article: Supplementary Table 2 from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary Table 2 from Repurposing Amiodarone for Bladder Cancer Treatment Open
List of differentially abundant proteins between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC)
View article: Figure 4 from Repurposing Amiodarone for Bladder Cancer Treatment
Figure 4 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Amiodarone induces apoptosis in bladder cancer cell lines. Cells were treated for 48 or 72 hours with amiodarone (0, 25, and 50 μmol/L for UMUC3; 0, 12.5, and 25 μmol/L for HT1197, BFTC905, and RT112). A, Apoptosis was evaluated usi…
View article: Supplementary Figure 2 from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary Figure 2 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Supplementary Figure 2. The effect of amiodarone is bladder cancer specific. Real-time proliferation assays in the benign bladder cells HBLAK using the IncucyteS3 System. The cells were treated with increasing concentrations of amiodarone …
View article: Figure 1 from Repurposing Amiodarone for Bladder Cancer Treatment
Figure 1 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Development of molecular signature and CMap analysis. A, A molecular signature was established through the integration of significant changes between MIBC and NMIBC derived from multiomics data (proteomics and transcriptomics), furt…
View article: Supplementary Table 1 from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary Table 1 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Differentially expressed genes (DEGs) between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NBIMC).
View article: Figure 2 from Repurposing Amiodarone for Bladder Cancer Treatment
Figure 2 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Amiodarone decreases proliferation in bladder cancer cell lines. Real-time proliferation assays in UMUC3, HT1197, BFTC905, and RT112 were conducted using the Incucyte S3 system. The cells were treated with increasing concentrations of amio…
View article: Figure 3 from Repurposing Amiodarone for Bladder Cancer Treatment
Figure 3 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Amiodarone decreases colony formation capacity in bladder cancer cell lines. Cells seeded in six-well plates were treated with increasing concentrations of amiodarone (0–5 μmol/L). After incubation for 7 to 10 days, the cells were stained …
View article: Supplementary Figure Legends from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary Figure Legends from Repurposing Amiodarone for Bladder Cancer Treatment Open
File contains 2 Supplementary Figure legends
View article: Figure 5 from Repurposing Amiodarone for Bladder Cancer Treatment
Figure 5 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Amiodarone reduces bladder cancer tumor growth in vivo. Tumor growth in BFTC905-bearing NOD/SCID mice treated with 75 mg/kg of amiodarone. A, Tumor volume over time in control (n = 6) and amiodarone-treated (n =…
View article: Supplementary File 2 from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary File 2 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Gene expression results
View article: Supplementary File 1 from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary File 1 from Repurposing Amiodarone for Bladder Cancer Treatment Open
The analysis based on the previously generated proteomics data
View article: Supplementary Figure 1 from Repurposing Amiodarone for Bladder Cancer Treatment
Supplementary Figure 1 from Repurposing Amiodarone for Bladder Cancer Treatment Open
Supplementary Figure 1. Fluvoxamine, amiodarone, isradipine, and amodiaquine reduce viability in BC cell lines. A, UMUC3, HT1197, BFTC905, and RT112 cells were treated for 96 h with increasing concentrations (0–100 μM) of fluvoxamine (A), …
View article: Data from Repurposing Amiodarone for Bladder Cancer Treatment
Data from Repurposing Amiodarone for Bladder Cancer Treatment Open
Cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy is the main treatment for muscle-invasive bladder cancer (MIBC). However, low survival rates highlight the necessity for new therapeutic strategies. Drug repurposing h…
View article: Repurposing Amiodarone for Bladder Cancer Treatment
Repurposing Amiodarone for Bladder Cancer Treatment Open
Cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy is the main treatment for muscle-invasive bladder cancer (MIBC). However, low survival rates highlight the necessity for new therapeutic strategies. Drug repurposing h…
View article: Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity
Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity Open
Objective: The study objective was to determine whether the clinical response of older adults with knee osteoarthritis and overweight or obesity to 18 months of diet and exercise (D + E) or attention control (C) interventions differed betw…
View article: Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges
Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges Open
Human hematopoietic stem cells (HSCs) have traditionally been viewed as self-renewing, multipotent cells with enormous potential in sustaining essential steady state blood and immune cell production throughout life. Indeed, around 86% (101…
View article: Prevalence and Clinical Characteristics of Sleep Disorders in Patients on Chronic Hemodialysis
Prevalence and Clinical Characteristics of Sleep Disorders in Patients on Chronic Hemodialysis Open
View article: Benefits and limits of decellularization on mass‐spectrometry‐based extracellular matrix proteome analysis of mouse kidney
Benefits and limits of decellularization on mass‐spectrometry‐based extracellular matrix proteome analysis of mouse kidney Open
The extracellular matrix (ECM) is composed of collagens, ECM glycoproteins, and proteoglycans (also named core matrisome proteins) that are critical for tissue structure and function, and matrisome‐associated proteins that balance the prod…
View article: Benefits and limits of decellularization on mass-spectrometry-based extracellular matrix proteome analysis of mouse kidney
Benefits and limits of decellularization on mass-spectrometry-based extracellular matrix proteome analysis of mouse kidney Open
Extracellular matrix (ECM) proteins, including collagens, ECM glycoproteins, and proteoglycans, are critical components of tissue structure and function. In addition to the core matrisome, there are matrisome-associated proteins that balan…
View article: Recent Advances in Mesenchymal Stem/Stromal Cell-Based Therapy for Alcohol-Associated Liver Disease and Non-alcoholic Fatty Liver Disease
Recent Advances in Mesenchymal Stem/Stromal Cell-Based Therapy for Alcohol-Associated Liver Disease and Non-alcoholic Fatty Liver Disease Open
Alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) represent pathological conditions that include many distinct stages, potentially leading to the final stage of cirrhotic liver. To date, liver transplanta…
View article: From multi-omics integrated signatures to repurposed drugs for bladder cancer treatment: The case of cephaeline
From multi-omics integrated signatures to repurposed drugs for bladder cancer treatment: The case of cephaeline Open
View article: MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology
MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology Open