Maria Giovanna Lupo
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View article: Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships
Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships Open
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia‐related diseases. A new class of small‐molecule inhibitors of PCSK9 transcription, characterized by a 4‐amino‐2‐…
View article: Sex-dependent behavioral responses and phenotypic traits of Pcsk9 knockout mice in anxiety- and depression-like paradigms
Sex-dependent behavioral responses and phenotypic traits of Pcsk9 knockout mice in anxiety- and depression-like paradigms Open
Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) regulates plasma LDL cholesterol by promoting the degradation of LDL receptors. Beyond lipid metabolism, PCSK9 has been implicated in neuropsychiatric conditions, including depression a…
View article: Glucagon-like peptide-1 receptor agonists and muscle mass effects
Glucagon-like peptide-1 receptor agonists and muscle mass effects Open
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed the management of obesity, demonstrating significant efficacy in inducing weight loss and improving metabolic parameters. However, emerging clinical and paraclinical ev…
View article: Pro-Inflammatory and Lipid Metabolism Dysregulating Effects of ANGPTL3 in THP-1 Macrophages
Pro-Inflammatory and Lipid Metabolism Dysregulating Effects of ANGPTL3 in THP-1 Macrophages Open
Background and aim: ANGPTL3 is a hepatokine acting as a negative regulator of lipoprotein lipase (LPL) through its N-terminal domain. Besides this activity, the C-terminal domain of ANGPTL3 interacts with integrin αVβ3. Since integrins are…
View article: Treatment With Inclisiran During Peritoneal Dialysis
Treatment With Inclisiran During Peritoneal Dialysis Open
View article: <i> <b>PCSK9</b> </i> <b>genetic variants, carotid atherosclerosis and vascular remodelling</b>
<i> <b>PCSK9</b> </i> <b>genetic variants, carotid atherosclerosis and vascular remodelling</b> Open
Background Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein chole…
View article: <i>PCSK9</i>genetic variants, carotid atherosclerosis and vascular remodelling
<i>PCSK9</i>genetic variants, carotid atherosclerosis and vascular remodelling Open
Background and aims Circulating PCSK9 is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein cholesterol (LDL-C) and reduced cardiovascul…
View article: Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization
Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization Open
View article: Neuronal PCSK9 Regulates Cognitive Performances via the Modulation of ApoER2 Synaptic Localization
Neuronal PCSK9 Regulates Cognitive Performances via the Modulation of ApoER2 Synaptic Localization Open
View article: Effects of ‘Mapo’ tangelo ( <i>Citrus</i> × <i>tangelo</i> ) extracts, essential oil, and isolated compounds on LDL receptor and PCSK9 expression in the human hepatocarcinoma cell line Huh7
Effects of ‘Mapo’ tangelo ( <i>Citrus</i> × <i>tangelo</i> ) extracts, essential oil, and isolated compounds on LDL receptor and PCSK9 expression in the human hepatocarcinoma cell line Huh7 Open
Peel, pulp extract and essential oil of Citrus × tangelo were studied for their ability to act on the expression of the LDL receptor and PCSK9 in the human hepatocarcinoma cell line Huh7.
View article: Extracellular vesicles powered cancer immunotherapy: Targeted delivery of adenovirus-based cancer vaccine in humanized melanoma model
Extracellular vesicles powered cancer immunotherapy: Targeted delivery of adenovirus-based cancer vaccine in humanized melanoma model Open
Malignant melanoma, a rapidly spreading form of skin cancer, is becoming more prevalent worldwide. While surgery is successful in treating early-stage melanoma, patients with advanced disease have only a 20 % chance of surviving beyond fiv…
View article: Advancements in risk stratification and management strategies in primary cardiovascular prevention
Advancements in risk stratification and management strategies in primary cardiovascular prevention Open
View article: Gene Silencing of Angiopoietin-like 3 (ANGPTL3) Induced De Novo Lipogenesis and Lipid Accumulation in Huh7 Cell Line
Gene Silencing of Angiopoietin-like 3 (ANGPTL3) Induced De Novo Lipogenesis and Lipid Accumulation in Huh7 Cell Line Open
Angiopoietin-like 3 (ANGPTL3) is a hepatokine acting as a negative regulator of lipoprotein lipase (LPL). Vupanorsen, an ANGPTL3 directed antisense oligonucleotide, showed an unexpected increase in liver fat content in humans. Here, we inv…
View article: Cytotoxic Pt(<scp>ii</scp>) complexes containing alizarin: a selective carrier for DNA metalation
Cytotoxic Pt(<span>ii</span>) complexes containing alizarin: a selective carrier for DNA metalation Open
A series of neutral Pt( ii ) complexes, bearing alizarin, were synthesized and characterized. In vitro cytotoxicity against triple negative breast cancer cell lines and their interaction with potential biological targets, were evaluated.
View article: Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability Open
Among the strategies to overcome the underperformance of statins in cardiovascular diseases (CVDs), the development of drugs targeting the Proprotein Convertase Subtilisin-like Kexin type 9 (PCSK9) is considered one of the most promising. …
View article: PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice
PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice Open
View article: Legacy perfluoro-alkyl substances impair LDL-cholesterol uptake independently from PCSK9-function
Legacy perfluoro-alkyl substances impair LDL-cholesterol uptake independently from PCSK9-function Open
View article: Bergamot (Citrus bergamia) peel extract as new hypocholesterolemic agent modulating PCSK9 expression
Bergamot (Citrus bergamia) peel extract as new hypocholesterolemic agent modulating PCSK9 expression Open
Citrus bergamia extracts have been studied for the management of hypercholesterolemia disorders. Up to now limited information is available concerning the activity of its main phytoconstituents towards the main targets of the cholesterol h…
View article: A differential proteomic analysis on HuH7 human hepatocarcinoma cell line naturally overexpressing or hypoexpressing LDLR: New proteins/pathways involved in cholesterol and triglycerides metabolism
A differential proteomic analysis on HuH7 human hepatocarcinoma cell line naturally overexpressing or hypoexpressing LDLR: New proteins/pathways involved in cholesterol and triglycerides metabolism Open
View article: ANGPTL3 silencing induces fat accumulation in hepatic HUH7 cell line
ANGPTL3 silencing induces fat accumulation in hepatic HUH7 cell line Open
View article: In vitro and in vivo studies on novel pcsk9 inhibitors as pharmacological approach for the treatment of alzheimer’s disease
In vitro and in vivo studies on novel pcsk9 inhibitors as pharmacological approach for the treatment of alzheimer’s disease Open
Aim: Impairment of cholesterol homeostasis is one of the multiple etiopathological mechanisms at the origin of both cardiovascular and neurodegenerative diseases. The PCSK9 protein, known for its role in the degradation of hepatic LDLR and…
View article: PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease
PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease Open
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer’s disease (AD) is poorly investigated. We evaluated the in vitro PCSK9 modulation of astrocyte cholesterol metabolism and neuronal cholesterol supplying, wh…
View article: Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9 Open
View article: In Vitro and In Vivo Sucrosomial® Berberine Activity on Insulin Resistance
In Vitro and In Vivo Sucrosomial® Berberine Activity on Insulin Resistance Open
Background: Berberine is a natural alkaloid with hypoglycemic properties. However, its therapeutic use is limited by a very low oral bioavailability. Here we developed a new oral formulation of berberine based on Sucrosomial® technology an…
View article: Deciphering the molecular mechanisms underlying the increase in PCSK9 plasma levels in response to anti-PCSK9 mabs: In vitro study in human hepatoma-derived Huh7 cells
Deciphering the molecular mechanisms underlying the increase in PCSK9 plasma levels in response to anti-PCSK9 mabs: In vitro study in human hepatoma-derived Huh7 cells Open
View article: ANGPTL3 induces a proinflammatory response in THP-1 derived macrophages
ANGPTL3 induces a proinflammatory response in THP-1 derived macrophages Open
View article: An innovative berberine formulation is able to improve bbr bioavailability and the lipid and glycemic profile in HFD-fed mice
An innovative berberine formulation is able to improve bbr bioavailability and the lipid and glycemic profile in HFD-fed mice Open
View article: Effects on lipids and pharmacokinetics parameters of PCSK9 mabs in a real life setting high CV risk patients
Effects on lipids and pharmacokinetics parameters of PCSK9 mabs in a real life setting high CV risk patients Open
View article: HDL Cholesterol Efflux and Serum Cholesterol Loading Capacity Alterations Associate to Macrophage Cholesterol Accumulation in FH Patients with Achilles Tendon Xanthoma
HDL Cholesterol Efflux and Serum Cholesterol Loading Capacity Alterations Associate to Macrophage Cholesterol Accumulation in FH Patients with Achilles Tendon Xanthoma Open
Achilles tendon xanthoma (ATX) formation involves macrophage cholesterol accumulation within the tendon, similar to that occurring in atheroma. Macrophage cholesterol homeostasis depends on serum lipoprotein functions, namely the high-dens…
View article: Investigating the in vitro mode of action of okra (Abelmoschus esculentus) as hypocholesterolemic, anti-inflammatory, and antioxidant food
Investigating the in vitro mode of action of okra (Abelmoschus esculentus) as hypocholesterolemic, anti-inflammatory, and antioxidant food Open