Maria Guo
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View article: AR-V7 condensates drive androgen-independent transcription in castration resistant prostate cancer
AR-V7 condensates drive androgen-independent transcription in castration resistant prostate cancer Open
Summary Biomolecular condensates organize cellular environments and regulate key processes such as transcription. We previously showed that full-length androgen receptor (AR-FL), a major oncogenic driver in prostate cancer (PCa), forms nuc…
View article: Novel Inhibitors of androgen receptor's DNA binding domain identified using an ultra‐large virtual screening
Novel Inhibitors of androgen receptor's DNA binding domain identified using an ultra‐large virtual screening Open
Androgen receptor (AR) inhibition remains the primary strategy to combat the progression of prostate cancer (PC). However, all clinically used AR inhibitors target the ligand‐binding domain (LBD), which is highly susceptible to truncations…