Maria J. Aristizabal
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View article: Uncovering allosteric communication in cancer-related histone mutations
Uncovering allosteric communication in cancer-related histone mutations Open
Background Histone mutations have been implicated in various cancers, but their mechanistic effects on chromatin dynamics remain largely unexplored. Aim To investigate how allosteric communication influences the functional outcomes of canc…
View article: Assessing the biological and molecular impacts of wildfire smoke exposure
Assessing the biological and molecular impacts of wildfire smoke exposure Open
Wildfire smoke exposure is an emerging health threat as wildfires increase in frequency and severity due to climate change. Wildfire smoke particulates contain organic free radicals and polycyclic aromatic hydrocarbons known to cause infla…
View article: Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability
Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability Open
Histones are key epigenetic factors that regulate the accessibility and compaction of eukaryotic genomes, affecting DNA replication and repair, and gene expression. Recent studies have demonstrated that histone missense mutations can pertu…
View article: Characteristics of early career health researchers and experiences of burnout during the COVID-19 pandemic in Canada
Characteristics of early career health researchers and experiences of burnout during the COVID-19 pandemic in Canada Open
Introduction The COVID-19 pandemic disrupted research globally. How it impacted Canadian early-career health researchers (ECHRs) remains unclear. We administered a survey to understand the composition of ECHRs in Canada, their job experien…
View article: An important role for triglyceride in regulating spermatogenesis
An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Author Response: An important role for triglyceride in regulating spermatogenesis
Author Response: An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Reviewer #1 (Public Review): An important role for triglyceride in regulating spermatogenesis
Reviewer #1 (Public Review): An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Reviewer #2 (Public Review): An important role for triglyceride in regulating spermatogenesis
Reviewer #2 (Public Review): An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: An important role for triglyceride in regulating spermatogenesis
An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: An important role for triglyceride in regulating spermatogenesis
An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Author Response: An important role for triglyceride in regulating spermatogenesis
Author Response: An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Reviewer #1 (Public Review): An important role for triglyceride in regulating spermatogenesis
Reviewer #1 (Public Review): An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Reviewer #2 (Public Review): An important role for triglyceride in regulating spermatogenesis
Reviewer #2 (Public Review): An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Low Glycolysis Is Neuroprotective during Anoxic Spreading Depolarization (SD) and Reoxygenation in Locusts
Low Glycolysis Is Neuroprotective during Anoxic Spreading Depolarization (SD) and Reoxygenation in Locusts Open
Migratory locusts enter a reversible hypometabolic coma to survive environmental anoxia, wherein the cessation of CNS activity is driven by spreading depolarization (SD). While glycolysis is recognized as a crucial anaerobic energy source …
View article: Leveraging Gene Redundancy to Find New Histone Drivers in Cancer
Leveraging Gene Redundancy to Find New Histone Drivers in Cancer Open
Histones play a critical role in chromatin function but are susceptible to mutagenesis. In fact, numerous mutations have been observed in several cancer types, and a few of them have been associated with carcinogenesis. Histones are peculi…
View article: An important role for triglyceride in regulating spermatogenesis
An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to normal sperm development is largely unknown.…
View article: An important role for triglyceride in regulating spermatogenesis
An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: Author Response: An important role for triglyceride in regulating spermatogenesis
Author Response: An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to normal sperm development is largely unknown.…
View article: Rapid cold hardening modifies mechanisms of ion regulation to delay anoxia-induced spreading depolarization in the CNS of<i>Locusta migratoria</i>
Rapid cold hardening modifies mechanisms of ion regulation to delay anoxia-induced spreading depolarization in the CNS of<i>Locusta migratoria</i> Open
Insects live in varied habitats and experience different kinds of environmental stresses. These stresses can impair neural performance, leading to spreading depolarization (SD) of nerve cells and neural shutdown underlying coma. The sensit…
View article: An important role for triglyceride in regulating spermatogenesis
An important role for triglyceride in regulating spermatogenesis Open
Drosophila is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emergi…
View article: A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in <i>Saccharomyces cerevisiae</i> and humans
A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in <i>Saccharomyces cerevisiae</i> and humans Open
The NuA4 lysine acetyltransferase complex acetylates histone and nonhistone proteins and functions in transcription regulation, cell cycle progression, and DNA repair. NuA4 harbors an interesting duality in that its catalytic module can fu…
View article: Risk-focused Differences in Molecular Processes Implicated in SARS-CoV-2 Infection: Corollaries in DNA Methylation and Gene Expression
Risk-focused Differences in Molecular Processes Implicated in SARS-CoV-2 Infection: Corollaries in DNA Methylation and Gene Expression Open
Background Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are more likely to acquir…
View article: Cdk8 directly regulates glycolysis via phosphorylation of Gcr2
Cdk8 directly regulates glycolysis via phosphorylation of Gcr2 Open
CDK8 encodes an evolutionarily conserved Mediator complex kinase subunit that functions in general and context-specific transcription regulation by phosphorylating core components of the transcription machinery and gene-specific transcript…
View article: Additional file 1 of Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression
Additional file 1 of Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression Open
Additional file 1: Table S1. List of candidate genes examined in the current study. Table S2. Results obtained from the sex-based expression analysis performed on the autosomal genes (segregated by tissues). Table S3. Results obtained from…
View article: OUP accepted manuscript
OUP accepted manuscript Open
Sex is a modulator of health that has been historically overlooked in biomedical research. Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a biological variable with the goal of stimulating efforts to i…
View article: Biological embedding of experience: A primer on epigenetics
Biological embedding of experience: A primer on epigenetics Open
Biological embedding occurs when life experience alters biological processes to affect later life health and well-being. Although extensive correlative data exist supporting the notion that epigenetic mechanisms such as DNA methylation und…