Jan N.M. IJzermans
YOU?
Author Swipe
View article: Simultaneous liver-kidney transplantation versus liver transplantation in end-stage liver disease patients with kidney dysfunction
Simultaneous liver-kidney transplantation versus liver transplantation in end-stage liver disease patients with kidney dysfunction Open
Introduction The role of simultaneous liver-kidney transplantation (SLKT) in end-stage liver disease patients with varying kidney dysfunction remains unclear. This study aims to compare clinical outcomes of SLKT recipients with those under…
View article: Developing an Adult Living Donor Liver Transplant Program in Western Europe: The Rotterdam Experience
Developing an Adult Living Donor Liver Transplant Program in Western Europe: The Rotterdam Experience Open
Liver transplantation (LT) is curative for end stage liver disease. Expanding LT indications with limited deceased donor grafts has created organ shortages. Living donor liver transplant (LDLT) increases available organs. In 2019, we resta…
View article: The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets Open
Most cancer proteomics studies to date have focused on a single cancer type. We report The Pan-Cancer Proteome Atlas (TPCPA) based on data-independent acquisition mass spectrometry, to better understand cancer biology and identify therapeu…
View article: Short-term fasting before living kidney donation has an immune-modulatory effect
Short-term fasting before living kidney donation has an immune-modulatory effect Open
Background Short-Term Fasting (STF) is an intervention reducing the intake of calories, without causing undernutrition or micronutrient-related malnutrition. It aims to systemically improve resilience against acute stress. Several (pre-)cl…
View article: Long-term Double-J stenting is superior to short-term Single-J stenting in kidney transplantation
Long-term Double-J stenting is superior to short-term Single-J stenting in kidney transplantation Open
Background and objectives Urological complications after kidney transplantation, due to the ureteroneocystostomy, are associated with significant morbidity, prolonged hospital stay and even mortality. Ureteral stents can minimize the numbe…
View article: <scp>NanoCMSer</scp> : a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples
<span>NanoCMSer</span> : a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples Open
Colorectal cancer (CRC) is a significant contributor to cancer‐related mortality, emphasizing the need for advanced biomarkers to guide treatment. As part of an international consortium, we previously categorized CRCs into four consensus m…
View article: Hepatocellular adenomas with severe intra-abdominal bleeding, related to an underlying coagulation disorder: a case report
Hepatocellular adenomas with severe intra-abdominal bleeding, related to an underlying coagulation disorder: a case report Open
Background Hepatocellular adenoma is a rare benign liver tumor. Typically, hepatocellular adenomas are solitary and are found in young women who use estrogen-containing contraceptives. The occurrence of multiple hepatocellular adenoma has …
View article: Benefit of adjuvant chemotherapy on recurrence free survival per consensus molecular subtype in stage <scp>III</scp> colon cancer
Benefit of adjuvant chemotherapy on recurrence free survival per consensus molecular subtype in stage <span>III</span> colon cancer Open
The consensus molecular subtype (CMS) classification divides colon tumors into four subtypes holding promise as a predictive biomarker. However, the effect of adjuvant chemotherapy on recurrence free survival (RFS) per CMS in stage III pat…
View article: Hybrid FDG-PET/MRI for Diagnosis and Clinical Management of Patients with Suspected Perihilar Cholangiocarcinoma: A Feasibility Pilot Study
Hybrid FDG-PET/MRI for Diagnosis and Clinical Management of Patients with Suspected Perihilar Cholangiocarcinoma: A Feasibility Pilot Study Open
Purpose Recently introduced hybrid 2-[18 F]-fluoro-2-deoxy-D-glucose (18 F-FDG) Positron Emission Tomography (PET) combined with Magnetic Resonance Imaging (MRI) may aid in proper diagnosis and staging of perihilar cholangiocarcinoma (pCCA…
View article: Evaluation of Hepatocellular Carcinoma Surveillance with Contrast-enhanced MRI in a High-Risk Western European Cohort
Evaluation of Hepatocellular Carcinoma Surveillance with Contrast-enhanced MRI in a High-Risk Western European Cohort Open
High-risk patients who underwent surveillance with contrast-enhanced MRI developed HCC in 17.5 % during a follow up period of over 4 years median. Very early stage HCC was seen in compensated cirrhosis after a median time interval of 10 mo…
View article: Clinical implications of nutritional interventions reducing calories, a systematic scoping review
Clinical implications of nutritional interventions reducing calories, a systematic scoping review Open
CR-like interventions (long-term CR or short-term fasting) are feasible in a broad range of patient populations. Whether it has clinical benefit, f.i. reducing treatment-induced side effects and enhancing therapy efficacy, has to be invest…
View article: Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation
Preoperative dietary intake of low-dose sulforaphane induces no clinically significant effect in living donor kidney transplantation Open
Introduction: Sulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a s…
View article: Cryptogenic non-cirrhotic HCC: Clinical, prognostic and immunologic aspects of an emerging HCC etiology
Cryptogenic non-cirrhotic HCC: Clinical, prognostic and immunologic aspects of an emerging HCC etiology Open
The incidence of hepatocellular carcinoma (HCC) in non-cirrhotic livers is rising significantly, but clear risk factors for screening remain elusive. This study sought to characterize non-cirrhotic HCC etiologies. HCC cases from 2009 to 20…
View article: Engaging stimulatory immune checkpoint interactions in the tumour immune microenvironment of primary liver cancers – how to push the gas after having released the brake
Engaging stimulatory immune checkpoint interactions in the tumour immune microenvironment of primary liver cancers – how to push the gas after having released the brake Open
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the first and second most common primary liver cancer (PLC). For decades, systemic therapies consisting of tyrosine kinase inhibitors (TKIs) or chemotherapy have formed the co…
View article: Successful adult domino living donor liver transplantation in methylmalonic acidemia: case report
Successful adult domino living donor liver transplantation in methylmalonic acidemia: case report Open
DLT using MMA grafts is a feasible strategy to treat end-stage liver disease and expand the donor organ pool. However, the recipient of the MMA domino liver may develop mild MMA which could affect quality of life, and long-term safety rema…
View article: Do treats facilitate the interpretation of findings on caloric restriction?
Do treats facilitate the interpretation of findings on caloric restriction? Open
Introduction Food can build social bonds and enhance interpersonal relationships. An area of research perhaps at odds with food abundance, is caloric restriction (CR), intermittent fasting (IF) or short-term fasting (STF). We aimed to stud…
View article: Quantifying the Disadvantage of Small Recipient Size on the Liver Transplantation Waitlist, a Longitudinal Analysis Within the Eurotransplant Region
Quantifying the Disadvantage of Small Recipient Size on the Liver Transplantation Waitlist, a Longitudinal Analysis Within the Eurotransplant Region Open
Background. Small adult patients with end-stage liver disease waitlisted for liver transplantation may face a shortage of size-matched liver grafts. This may result in longer waiting times, increased waitlist removal, and waitlist mortalit…
View article: Impact of Extraction Time During Donation After Circulatory Death Organ Procurement on Kidney Function After Transplantation in The Netherlands
Impact of Extraction Time During Donation After Circulatory Death Organ Procurement on Kidney Function After Transplantation in The Netherlands Open
Background. In The Netherlands, 60% of deceased-donor kidney offers are after donation after circulatory death. Cold and warm ischemia times are known risk factors for delayed graft function (DGF) and inferior allograft survival. Extractio…
View article: Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts
Impact of sarcopenia on clinical outcomes for patients with resected hepatocellular carcinoma: a retrospective comparison of Eastern and Western cohorts Open
Background: Patient fitness is important for guiding treatment. Muscle mass, as a reflection thereof, can be objectively measured. However, the role of East–West differences remains unclear. Therefore, we compared the impact of muscle mass…