María‐José Sánchez
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View article: Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis
Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis Open
Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. Methods We investigated associations …
View article: Supplementary Table 2 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Supplementary Table 2 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
AUC results for PSA and the 4K score models with prostate cancer overall and clinically relevant disease subtypes and among men with elevated PSA who were under the age of 60 at recruitment and over the age of 60 at recruitment
View article: Supplementary Table 1 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Supplementary Table 1 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
AUC results for PSA and the 4K score models with prostate cancer overall and clinically relevant disease subtypes and among men with elevated PSA developed cancer within five years of recruitment and more than five years after recruitment
View article: Supplementary Table 3 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Supplementary Table 3 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
AUC results for PSA and the 4K score models with prostate cancer overall and clinically relevant disease subtypes and among men with elevated PSA stratified by EPIC recruitment country
View article: Table 3 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Table 3 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
Correlations between analytes and 4Kscore.
View article: Table 1 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Table 1 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
Characteristics of control participants and patients with prostate cancer.
View article: Data from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Data from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
Background:PSA is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore (OPKO Diagnostics) versus total PSA in predicting short- and long-term risks of aggressive …
View article: Table 2 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Table 2 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
Adjusted geometric mean PSA concentration (ng/mL) and 4Kscore in controls by selected characteristics.
View article: Supplementary Table 4 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Supplementary Table 4 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
AUC results for PSA and the 4K score models with prostate cancer overall and clinically relevant disease subtypes stratified by EPIC recruitment centre
View article: Table 4 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Table 4 from Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
AUC results for PSA and the 4Kscore models with prostate cancer overall and clinically relevant disease subtypes and among men with elevated PSA who developed cancer.
View article: Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition
Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition Open
Lifestyle changes, as measured by the HLI, during mid-adulthood were not significantly associated with the risk of postmenopausal breast cancer. More specifically, the results of this study suggested that a shift towards a healthier BMI ma…
View article: Quizartinib for Newly Diagnosed <i>FLT3</i> -Internal Tandem Duplication–Negative AML: The Randomized, Double-Blind, Placebo-Controlled, Phase II QUIWI Study
Quizartinib for Newly Diagnosed <i>FLT3</i> -Internal Tandem Duplication–Negative AML: The Randomized, Double-Blind, Placebo-Controlled, Phase II QUIWI Study Open
PURPOSE Quizartinib, an oral, selective, second-generation, type-II FMS-like tyrosine kinase 3 (FLT3) inhibitor with high binding affinity to internal tandem duplication (ITD) and wild-type (WT) FLT3, has shown early clinical activity as m…
View article: Total petroleum hydrocarbons (TPHs) in groundwater of the Ecuadorian Amazon: Implications for human health
Total petroleum hydrocarbons (TPHs) in groundwater of the Ecuadorian Amazon: Implications for human health Open
The Ecuadorian Amazon, particularly in the provinces of Sucumbíos and Orellana, has been heavily impacted by oil activity since the 1970s. In this context, this study carried out between March and June 2024 analyzed 161 groundwater samples…
View article: Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review Open
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. Early detection and personalised prevention strategies are crucial for reducing the burden of CVD. The use of biomarkers plays a pivotal role in iden…
View article: Insights from the development of an online toolkit to promote community engaged substance use research in the Southwest Borderlands Region
Insights from the development of an online toolkit to promote community engaged substance use research in the Southwest Borderlands Region Open
The Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (EXPLORE) Toolkit is an online resource designed to support researchers and frontline workers addressing substance use in the Borderlands region of the …
View article: Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement
Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement Open
View article: Second primary cancers in breast cancer survivors
Second primary cancers in breast cancer survivors Open
View article: Circulating fatty acid binding protein 4 (<scp>FABP</scp>‐4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study
Circulating fatty acid binding protein 4 (<span>FABP</span>‐4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study Open
Human fatty acid binding protein‐4 (FABP‐4), a protein elevated in obesity that promotes colon cancer cell invasiveness and metastasis, may be associated with higher mortality in individuals with colorectal cancer (CRC) and may serve as a …
View article: Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition
Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Open
Background: PSA is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore (OPKO Diagnostics) versus total PSA in predicting short- and long-term risks of aggressive…
View article: Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC) Open
Assessment of biological ageing using proteomic clocks may enhance risk prediction and elucidate the molecular links between ageing and chronic diseases. Within a pre-diagnostic cohort of 17,473 Europeans with up to 28 years of follow-up, …
View article: Body mass index and breast cancer risk among postmenopausal women with and without cardiometabolic diseases: Findings from two prospective cohort studies in Europe
Body mass index and breast cancer risk among postmenopausal women with and without cardiometabolic diseases: Findings from two prospective cohort studies in Europe Open
Background Adiposity, measured by body mass index (BMI), is a known risk factor for postmenopausal breast cancer. However, whether the association of BMI with breast cancer risk differs among women with and without cardiovascular diseases …
View article: Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?
Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk? Open
Background Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomics offers potential …
View article: Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition
Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition Open
Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood …
View article: Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies
Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies Open
Background Dietary guidelines recommend replacing saturated fatty acid with unsaturated fats, particularly polyunsaturated fatty acids. Cohort studies do not suggest a clear benefit of higher intake of polyunsaturated fatty acids but, in c…
View article: Trends in the incidence of brain cancer and the use of mobile phones: analysis of the Spanish Network of Cancer Registries (REDECAN)
Trends in the incidence of brain cancer and the use of mobile phones: analysis of the Spanish Network of Cancer Registries (REDECAN) Open
Purpose The association between the use of mobile phones use and the risk of brain cancer remains controversial. The aim of this study is to describe trends in the incidence of central nervous system (CNS) cancers in Spain and its possible…
View article: Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study Open
Genetic susceptibility to an evening-like chronotype prone to overweight/obesity seems to be associated with a smaller serving size during breakfast, with lower protein and carbohydrate content.
View article: Dietary and lifestyle determinants of vitamin D status in the UK Biobank Cohort study for predictive modeling
Dietary and lifestyle determinants of vitamin D status in the UK Biobank Cohort study for predictive modeling Open
Vitamin D (VD) is involved in a wide variety of physiological processes. The high prevalence of VD deficiency in the population requires stronger preventive measures. The aim was to characterize the dietary and lifestyle determinants of VD…
View article: Supplementary figure S1 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary figure S1 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary figure S1: Total variation in the metabolomics data and its sources before and after the normalization procedure Panel A shows the overall variability and its sources before the normalization procedure and panel B shows the o…
View article: Supplementary figure S3 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary figure S3 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary figure S3: The contribution to the metabolic signature of each identified metabolite This graph shows the loadings of the metabolites contributing to the metabolomic signature. Higher bars correspond to larger contribution of…
View article: Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary table S6: Associations of physical activity with the metabolites analysed in the EPIC study without BMI adjustment.