María José Ramos-Medina
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View article: Reprogramming cancer immunity with next-generation combination therapies
Reprogramming cancer immunity with next-generation combination therapies Open
Cancer immunotherapy has fundamentally reshaped oncology by harnessing the immune system to eliminate malignant cells. Immune checkpoint inhibitors targeting CTLA-4 and PD-1/PD-L1 have achieved durable remissions in select cancers, yet mos…
View article: Worldwide analysis of actionable genomic alterations in lung cancer and targeted pharmacogenomic strategies
Worldwide analysis of actionable genomic alterations in lung cancer and targeted pharmacogenomic strategies Open
Based on data from the Global Cancer Statistics 2022, lung cancer stands as the most lethal cancer worldwide, with age-adjusted incidence and mortality rates of 23.6 and 16.9 per 100,000 people, respectively. Despite significant strides in…
View article: Gastric cancer actionable genomic alterations across diverse populations worldwide and pharmacogenomics strategies based on precision oncology
Gastric cancer actionable genomic alterations across diverse populations worldwide and pharmacogenomics strategies based on precision oncology Open
Introduction: Gastric cancer is one of the most prevalent types of cancer worldwide. The World Health Organization (WHO), the International Agency for Research on Cancer (IARC), and the Global Cancer Statistics (GLOBOCAN) reported an age s…
View article: The pharmacoepigenetic paradigm in cancer treatment
The pharmacoepigenetic paradigm in cancer treatment Open
Epigenetic modifications, characterized by changes in gene expression without altering the DNA sequence, play a crucial role in the development and progression of cancer by significantly influencing gene activity and cellular function. Thi…
View article: CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases
CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases Open
View article: Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis
Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis Open
View article: Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy
Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy Open
The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the SMN1 and SMN2 genes…
View article: Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials
Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials Open
Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. Respiratory failure is the main cause of death in severe COVID-19 patients, and the host inflammatory response at the lungs remains poorly unde…
View article: Single-nucleus lung transcriptomics and inflammatory responses in lethal COVID-19 reveal potential drugs in advanced-stage clinical trials
Single-nucleus lung transcriptomics and inflammatory responses in lethal COVID-19 reveal potential drugs in advanced-stage clinical trials Open
There is pressing urgency to identify drugs that allow treating COVID-19 patients effectively. Respiratory failure is the leading cause of death in patients with severe COVID-19, and the host inflammatory response at the lungs remains poor…