Maria Kalafateli
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View article: Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach
Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach Open
Irritable Bowel Syndrome (IBS) is a prevalent and heterogeneous functional gastrointestinal disorder with a complex and multifactorial pathophysiology. Traditional treatment approaches have focused on symptom relief, often overlooking the …
View article: Characteristics and Treatment of Primary Hepatic Perivascular Epithelioid Cell Tumor (PEComa) in Adults: A Systematic Review
Characteristics and Treatment of Primary Hepatic Perivascular Epithelioid Cell Tumor (PEComa) in Adults: A Systematic Review Open
Background: Perivascular epithelioid cell tumors (PEComas) are a rare group of mesenchymal neoplasms with distinctive histological and immunohistochemical features. This systematic review aims to characterize the clinical presentation, dia…
View article: Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease in a Cohort of Patients With Chronic Hepatitis B
Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease in a Cohort of Patients With Chronic Hepatitis B Open
In this large European cohort, MASLD and fibrosis were highly prevalent among patients with CHB, whereas MASLD aggravated liver fibrosis. Though screening strategies remain inconsistent, ferritin levels, increased BMI, and type 2 diabetes …
View article: Recent Advances in the Use of Vitamin D Organic Nanocarriers for Drug Delivery
Recent Advances in the Use of Vitamin D Organic Nanocarriers for Drug Delivery Open
Nanotechnology, now established as a transformative technology, has revolutionized medicine by enabling highly targeted drug delivery. The use of organic nanocarriers in drug delivery systems significantly enhances the bioavailability of v…
View article: Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C
Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C Open
Both the FIB-4 score and the Forns index may be considered for the initial assessment of people with CHC. The FIB-4 score's low cut-off (1.45) can be used to rule out people with at least severe fibrosis (≥ F3) and cirrhosis (F4). The Forn…
View article: Predictive Risk Factors and Scoring Systems Associated with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B
Predictive Risk Factors and Scoring Systems Associated with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B Open
Chronic hepatitis B (CHB) infection constitutes a leading cause of hepatocellular carcinoma (HCC) development. The identification of HCC risk factors and the development of prognostic risk scores are essential for early diagnosis and progn…
View article: Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability, Validity, and Responsiveness
Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability, Validity, and Responsiveness Open
Chronic hepatitis B (CHB) constitutes a major global public health issue, affecting millions of individuals. Despite the implementation of robust vaccination programs, the hepatitis B virus (HBV) significantly influences morbidity and mort…
View article: Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma: Where Do We Stand?
Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma: Where Do We Stand? Open
Hepatocellular carcinoma (HCC) remains a global health challenge that urgently calls for innovative therapeutic strategies. Chimeric antigen receptor T cell (CAR T) therapy has emerged as a promising avenue for HCC treatment. However, the …
View article: Exploring the role of IL-1β in inflammatory bowel disease pathogenesis
Exploring the role of IL-1β in inflammatory bowel disease pathogenesis Open
Interleukin 1β (IL-1β) is a significant mediator of inflammation and tissue damage in IBD. The balance between IL-1β and its endogenous inhibitor-IL-1Ra-, plays a critical role in both initiation and regulation of inflammation. However, th…
View article: Low Urinary Free Cortisol as a Risk Factor for Patients with Variceal Bleeding
Low Urinary Free Cortisol as a Risk Factor for Patients with Variceal Bleeding Open
Background and Objectives: Specificity and reliability issues of the current cortisol assessment methods lead to limitations on the accurate assessment of relative adrenal insufficiency. Although free cortisol provides a more accurate eval…
View article: Epigenetic Regulation in Lean Nonalcoholic Fatty Liver Disease
Epigenetic Regulation in Lean Nonalcoholic Fatty Liver Disease Open
Nonalcoholic fatty liver disease (NAFLD), the most prominent cause of chronic liver disease worldwide, is a rapidly growing epidemic. It consists of a wide range of liver diseases, from steatosis to nonalcoholic steatohepatitis, and predis…
View article: Endotoxin Translocation and Gut Barrier Dysfunction Are Related to Variceal Bleeding in Patients With Liver Cirrhosis
Endotoxin Translocation and Gut Barrier Dysfunction Are Related to Variceal Bleeding in Patients With Liver Cirrhosis Open
Background Bacterial infections are associated with the risk of variceal bleeding through complex pathophysiologic pathways. Objectives The primary objective of the present case-control study was to investigate the role of bacterial transl…
View article: Efficacy of Infliximab after Failure of Subcutaneous Anti-TNF Agents in Patients with Moderate to Severe Ulcerative Colitis
Efficacy of Infliximab after Failure of Subcutaneous Anti-TNF Agents in Patients with Moderate to Severe Ulcerative Colitis Open
Aim: To assess the efficacy of infliximab in ulcerative colitis (UC) patients who had failed therapy with adalimumab or golimumab.
Methods: Retrospective analysis of prospectively acquired data of all anti-TNF naive patients with moderate…
View article: Cardiovascular morbidity and mortality is increased post‐liver transplantation even in recipients with no pre‐existing risk factors
Cardiovascular morbidity and mortality is increased post‐liver transplantation even in recipients with no pre‐existing risk factors Open
Background/aims Post‐liver transplant (LT) metabolic syndrome (PTMS) and cardiovascular (CVS) mortality are becoming increasingly prevalent following sustained improvements in post‐LT survival. We investigated the prevalence and predictors…
View article: Pharmacological interventions for acute hepatitis C infection
Pharmacological interventions for acute hepatitis C infection Open
Background Hepatitis C virus (HCV) is a single‐stranded RNA (ribonucleic acid) virus that has the potential to cause inflammation of the liver. The traditional definition of acute HCV infection is the first six months following infection w…
View article: Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis
Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis Open
Several polymorphisms in the vitamin D receptor ( VDR ) are associated with the occurrence of chronic liver disease. Here, we investigated the association between BsmI, ApaI, TaqI and FokI VDR polymorphisms and the severity of liver cirrho…
View article: P931Low voltage areas detected by high-density electroanatomical mapping predict recurrence after ablation for paroxysmal atrial fibrillation
P931Low voltage areas detected by high-density electroanatomical mapping predict recurrence after ablation for paroxysmal atrial fibrillation Open
View article: Muscle fat infiltration assessed by total psoas density on computed tomography predicts mortality in cirrhosis
Muscle fat infiltration assessed by total psoas density on computed tomography predicts mortality in cirrhosis Open
Muscle fat infiltration, as a result of sarcopenia, is a negative predictive factor of survival in cirrhosis, emphasizing the need for early identification of this subgroup of patients.
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Potential conflict of interest: Nothing to report. We thank Dr. Pedersen and colleagues for their interest in our work, and we welcome the external validation of the Royal Free Hospital Cirrhosis Glomerular Filtration Rate (GFR).1 As a gen…
View article: Pharmacological interventions for alcoholic liver disease (alcohol-related liver disease)
Pharmacological interventions for alcoholic liver disease (alcohol-related liver disease) Open
Because of very low-quality evidence, there is uncertainty in the effectiveness of any pharmacological intervention versus no intervention in people with alcoholic hepatitis or severe alcoholic hepatitis. Based on low-quality evidence, pro…
View article: Pharmacological interventions for acute hepatitis C infection
Pharmacological interventions for acute hepatitis C infection Open
Very low quality evidence suggests that interferon-alpha may decrease the incidence of chronic HCV infection as measured by sustained virological response. However, the clinical impact such as improvement in health-related quality of life,…
View article: Interventions for hereditary haemochromatosis
Interventions for hereditary haemochromatosis Open
There is currently insufficient evidence to determine whether erythrocytapheresis is beneficial or harmful compared with phlebotomy. Phlebotomy has less equipment requirements and remains the treatment of choice in people with hereditary h…
View article: A meta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome
A meta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome Open
This meta-analysis suggests that the ER pattern is associated with a high risk of arrhythmic events in patients with BS. In particular, BS patients with inferolateral ER (global ER pattern) displayed the highest arrhythmic risk.
View article: Spontaneous Cirrhosis Regression in an IFN-beta-induced AIH-like Syndrome Following Drug Withdrawal: Art of Facts or Artifacts?
Spontaneous Cirrhosis Regression in an IFN-beta-induced AIH-like Syndrome Following Drug Withdrawal: Art of Facts or Artifacts? Open
Autoimmune hepatitis (AIH) is a disease of unknown aetiology with drug-induced AIH being the most complex and not fully understood type. We present the case of a 57-year-old female patient with acute icteric hepatitis after interferon-beta…
View article: Malnutrition and sarcopenia predict post‐liver transplantation outcomes independently of the Model for End‐stage Liver Disease score
Malnutrition and sarcopenia predict post‐liver transplantation outcomes independently of the Model for End‐stage Liver Disease score Open
Background Although malnutrition and sarcopenia are prevalent in cirrhosis, their impact on outcomes following liver transplantation is not well documented. Methods The associations of nutritional status and sarcopenia with post‐transplant…
View article: Multidetector computed tomography versus platelet/spleen diameter ratio as methods for the detection of gastroesophageal varices.
Multidetector computed tomography versus platelet/spleen diameter ratio as methods for the detection of gastroesophageal varices. Open
MDCT was accurate for the detection of gastroesophageal varices, especially those with clinically significant size (>5 mm), and superior to platelet/spleen diameter ratio. MDCT could replace, in selected patients, upper GI endoscopy as a m…
View article: Epidemiology of hepatitis C in Greece
Epidemiology of hepatitis C in Greece Open
Hepatitis C is a global health issue and constitutes a major cause of chronic liver disease worldwide. In this article, a comprehensive literature search was conducted for the prevalence of hepatitis C virus (HCV) infection in Greece, sinc…
View article: Efficacy of Interferon A-2b Monotherapy in Β-Thalassemics with Chronic Hepatitis C
Efficacy of Interferon A-2b Monotherapy in Β-Thalassemics with Chronic Hepatitis C Open
Background & Aims: Monotherapy with standard or pegylated interferon (PegIFN) remains the first-line treatment for HCV infection in patients with thalassemia major (ßTM), although its long-term impact is still unknown. We aimed to assess t…
View article: Impact of muscle wasting on survival in patients with liver cirrhosis
Impact of muscle wasting on survival in patients with liver cirrhosis Open
Muscle wasting is defined as the progressive and generalized loss of muscle mass. Muscle depletion is a common feature of chronic liver disease found in approximately 40% of patients with cirrhosis. Its etiology is multifactorial subsequen…
View article: Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis
Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis Open
Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis.