Maria Karlsson
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View article: Identification and Characterization of Vancomycin-Resistant <i>Staphylococcus aureus</i> CC45/USA600, North Carolina, USA, 2021
Identification and Characterization of Vancomycin-Resistant <i>Staphylococcus aureus</i> CC45/USA600, North Carolina, USA, 2021 Open
Vancomycin-resistant Staphylococcus aureus (VRSA) is a rare but serious public health concern. We describe a VRSA case in North Carolina, USA. The isolate from the case belonged to the USA600 lineage and clonal complex 45. No transmission …
View article: Characterization of carbapenem-resistant Enterobacterales and <i>Pseudomonas aeruginosa</i> carrying multiple carbapenemase genes—Antimicrobial Resistance Laboratory Network, 2018–2022
Characterization of carbapenem-resistant Enterobacterales and <i>Pseudomonas aeruginosa</i> carrying multiple carbapenemase genes—Antimicrobial Resistance Laboratory Network, 2018–2022 Open
Carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) are significant public health threats, particularly when harboring carbapenemases. Literature describing the frequencies and phenotypic and …
View article: Sentinel Surveillance reveals phylogenetic diversity and detection of linear plasmids harboring <i>vanA</i> and <i>optrA</i> among enterococci collected in the United States
Sentinel Surveillance reveals phylogenetic diversity and detection of linear plasmids harboring <i>vanA</i> and <i>optrA</i> among enterococci collected in the United States Open
Enterococcus faecalis and Enterococcus faecium are frequent causes of healthcare-associated infections. Antimicrobial-resistant enterococci pose a serious public health threat, particularly vancomycin-resistant enterococci (VRE), for which…
View article: Complete genome sequences of <i>Clostridioides difficile</i> surveillance isolates representing the top 10 ribotypes from the Emerging Infections Program, United States, 2016
Complete genome sequences of <i>Clostridioides difficile</i> surveillance isolates representing the top 10 ribotypes from the Emerging Infections Program, United States, 2016 Open
Ten Clostridioides difficile isolates representing the top 10 ribotypes collected in 2016 through the Emerging Infections Program underwent long-read sequencing to obtain high-quality reference genome assemblies. These isolates are publicl…
View article: 2747. Aztreonam-Avibactam Susceptibility Testing Program for Metallo-β-Lactamase-Producing Enterobacterales collected through the Antimicrobial Resistance Laboratory Network, March 2019 to April 2023
2747. Aztreonam-Avibactam Susceptibility Testing Program for Metallo-β-Lactamase-Producing Enterobacterales collected through the Antimicrobial Resistance Laboratory Network, March 2019 to April 2023 Open
Background Metallo-β-lactamase-producing Enterobacterales (MBL-E) are a major public health concern as they cause infections with few effective treatment options. Aztreonam-avibactam (AZA) is a β-lactam/β-lactamase inhibitor combination ag…
View article: Comparison of carbapenem-susceptible and carbapenem-resistant Enterobacterales at nine sites in the USA, 2013–2016: a resource for antimicrobial resistance investigators
Comparison of carbapenem-susceptible and carbapenem-resistant Enterobacterales at nine sites in the USA, 2013–2016: a resource for antimicrobial resistance investigators Open
Carbapenem-resistant Enterobacterales (CRE) are an urgent public health threat. Genomic sequencing is an important tool for investigating CRE. Through the Division of Healthcare Quality Promotion Sentinel Surveillance system, we collected …
View article: Antimicrobial Resistance Laboratory Network’s multisite evaluation of the ThermoFisher Sensititre GN7F broth microdilution panel for antimicrobial susceptibility testing
Antimicrobial Resistance Laboratory Network’s multisite evaluation of the ThermoFisher Sensititre GN7F broth microdilution panel for antimicrobial susceptibility testing Open
In 2017, the Centers for Disease Control and Prevention (CDC) established the Antimicrobial Resistance Laboratory Network to improve domestic detection of multidrug-resistant organisms. CDC and four laboratories evaluated a commercial brot…
View article: Development of a Broth Microdilution Method To Characterize Chlorhexidine MICs among Bacteria Collected from 2005 to 2019 at Three U.S. Sites
Development of a Broth Microdilution Method To Characterize Chlorhexidine MICs among Bacteria Collected from 2005 to 2019 at Three U.S. Sites Open
Chlorhexidine bathing to prevent transmission of multidrug-resistant organisms and reduce health care-associated infections has been adopted by many hospitals. There is concern about the possible unintended consequences of using this agent…
View article: Reference Susceptibility Testing and Genomic Surveillance of<i>Clostridioides difficile</i>, United States, 2012–17
Reference Susceptibility Testing and Genomic Surveillance of<i>Clostridioides difficile</i>, United States, 2012–17 Open
Background Antimicrobial susceptibility testing (AST) is not routinely performed for Clostridioides difficile and data evaluating minimum inhibitory concentrations (MICs) are limited. We performed AST and whole genome sequencing (WGS) for …
View article: Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Collected through CDC’s Emerging Infections Program, United States, 2016–2018
Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Collected through CDC’s Emerging Infections Program, United States, 2016–2018 Open
The CDC’s Emerging Infections Program (EIP) conducted population- and laboratory-based surveillance of US carbapenem-resistant Pseudomonas aeruginosa (CRPA) from 2016 through 2018. To characterize the pathotype, 1,019 isolates collected th…
View article: Evaluation of MALDI Biotyper Mycobacteria Library for Identification of Nontuberculous Mycobacteria
Evaluation of MALDI Biotyper Mycobacteria Library for Identification of Nontuberculous Mycobacteria Open
The Bruker Biotyper matrix-assisted laser desorption ionization–time-of-flight mass spectrometry (MALDI-TOF MS) platform was assessed on its ability to accurately identify 314 nontuberculous mycobacteria (NTM) representing 73 species. All …
View article: Characterization of carbapenem-resistant gram-negative bacteria collected in the Sentinel Surveillance Program, 2018–2019
Characterization of carbapenem-resistant gram-negative bacteria collected in the Sentinel Surveillance Program, 2018–2019 Open
Background: Carbapenem resistance in gram-negative organisms is an important public health problem. The CDC conducted Sentinel surveillance in 2018–2019 to characterize these organisms from 9 facilities in 9 different states. Methods: Carb…
View article: Molecular Characterization of Carbapenem-Resistant Enterobacterales Collected in the United States
Molecular Characterization of Carbapenem-Resistant Enterobacterales Collected in the United States Open
Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to resistance to multiple antibiotics and potential to cause health care-associated infections with high mortality. Carbapenemase-producing CRE are of part…
View article: Epidemiology of extended-spectrum β-lactamase–producing Enterobacterales in five US sites participating in the Emerging Infections Program, 2017
Epidemiology of extended-spectrum β-lactamase–producing Enterobacterales in five US sites participating in the Emerging Infections Program, 2017 Open
Objective The incidence of infections from extended-spectrum β-lactamase (ESBL)–producing Enterobacterales (ESBL-E) is increasing in the United States. We describe the epidemiology of ESBL-E at 5 Emerging Infections Program (EIP) sites. Me…
View article: Sentinel Surveillance Reveals Emerging Daptomycin-Resistant ST736 Enterococcus faecium and Multiple Mechanisms of Linezolid Resistance in Enterococci in the United States
Sentinel Surveillance Reveals Emerging Daptomycin-Resistant ST736 Enterococcus faecium and Multiple Mechanisms of Linezolid Resistance in Enterococci in the United States Open
Enterococcus faecalis and faecium with resistance to daptomycin and/or linezolid are emerging globally. We present the genomic characterization of daptomycin- and linezolid-resistant E. faecalis and E. faecium surveillance isolates from th…
View article: Characterization of the First Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate Harboring <i>bla</i> <sub>SIM-1</sub> from the United States
Characterization of the First Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate Harboring <i>bla</i> <sub>SIM-1</sub> from the United States Open
The emergence and transmission of metallo-β-lactamases (MBL) are significant public health concerns that threaten the utility of antimicrobial therapy (1, 2). Seoul imipenemase (SIM)-type MBL genes, blaSIM-1 and blaSIM-2, have been identif…
View article: Carbapenemase production among less-common Enterobacterales genera: 10 US sites, 2018
Carbapenemase production among less-common Enterobacterales genera: 10 US sites, 2018 Open
Background Historically, United States’ carbapenem-resistant Enterobacterales (CRE) surveillance and mechanism testing focused on three genera: Escherichia, Klebsiella, and Enterobacter (EsKE); however, other genera can harbour mobile carb…
View article: Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing <i>Enterobacterales</i> in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020
Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing <i>Enterobacterales</i> in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020 Open
Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreona…
View article: Sensitization of the UPR by Loss of PPP1R15A Promotes Fibrosis and Senescence in IPF
Sensitization of the UPR by Loss of PPP1R15A Promotes Fibrosis and Senescence in IPF Open
The unfolded protein response (UPR) is a direct consequence of cellular endoplasmic reticulum (ER) stress and a key disease driving mechanism in IPF. The resolution of the UPR is directed by PPP1R15A (GADD34) and leads to the restoration o…
View article: Acquisition of Ciprofloxacin Resistance Among an Expanding Clade of β-Lactamase–Positive, Serogroup Y <i>Neisseria meningitidis</i> in the United States
Acquisition of Ciprofloxacin Resistance Among an Expanding Clade of β-Lactamase–Positive, Serogroup Y <i>Neisseria meningitidis</i> in the United States Open
Background Penicillin and ciprofloxacin are important for invasive meningococcal disease (IMD) management and prevention. IMD cases caused by penicillin- and ciprofloxacin-resistant Neisseria meningitidis containing a ROB-1 β-lactamase gen…
View article: Antimicrobial Susceptibility Profiles To Predict the Presence of Carbapenemase Genes among Carbapenem-Resistant Pseudomonas aeruginosa Isolates
Antimicrobial Susceptibility Profiles To Predict the Presence of Carbapenemase Genes among Carbapenem-Resistant Pseudomonas aeruginosa Isolates Open
Detection of carbapenem-resistant Pseudomonas aeruginosa (CRPA) with carbapenemase-producing (CP) genes is critical for preventing transmission. Our objective was to assess whether certain antimicrobial susceptibility testing (AST) profile…
View article: Characterization of Clostridioides difficile Isolates Available through the CDC & FDA Antibiotic Resistance Isolate Bank
Characterization of Clostridioides difficile Isolates Available through the CDC & FDA Antibiotic Resistance Isolate Bank Open
Thirty Clostridioides difficile isolates collected in 2016 through the Centers for Disease Control and Prevention Emerging Infections Program were selected for reference antimicrobial susceptibility testing and whole-genome sequencing. Her…
View article: Gram-Negative Bacteria Harboring Multiple Carbapenemase Genes, United States, 2012–2019
Gram-Negative Bacteria Harboring Multiple Carbapenemase Genes, United States, 2012–2019 Open
Reports of organisms harboring multiple carbapenemase genes have increased since 2010. During October 2012-April 2019, the Centers for Disease Control and Prevention documented 151 of these isolates from 100 patients in the United States. …
View article: Assessing the <i>in vitro</i> impact of ceftazidime on aztreonam/avibactam susceptibility testing for highly resistant MBL-producing Enterobacterales
Assessing the <i>in vitro</i> impact of ceftazidime on aztreonam/avibactam susceptibility testing for highly resistant MBL-producing Enterobacterales Open
Background Aztreonam/avibactam is a combination agent that shows promise in treating infections caused by highly antibiotic-resistant MBL-producing Enterobacterales. This combination can be achieved by combining two FDA-approved drugs: cef…
View article: Evaluation of Discrepancies in Carbapenem Minimum Inhibitory Concentrations Obtained at Clinical Laboratories Compared to a Public Health Laboratory
Evaluation of Discrepancies in Carbapenem Minimum Inhibitory Concentrations Obtained at Clinical Laboratories Compared to a Public Health Laboratory Open
Background: Automated testing instruments (ATIs) are commonly used by clinical microbiology laboratories to perform antimicrobial susceptibility testing (AST), whereas public health laboratories may use established reference methods such a…
View article: New Approaches to Colonization Screening in Response to Emerging Antimicrobial Resistance
New Approaches to Colonization Screening in Response to Emerging Antimicrobial Resistance Open
Background: The capacity to monitor the emergence of carbapenemase-producing organisms (CPO) is critical in limiting transmission. CPO-colonized patients can be identified by screening rectal specimens for carbapenemase genes and the Cephe…
View article: Pilot Program for Aztreonam-Avibactam Susceptibility Testing of Metallo-Beta-Lactamase-Producing Enterobacteriaceae
Pilot Program for Aztreonam-Avibactam Susceptibility Testing of Metallo-Beta-Lactamase-Producing Enterobacteriaceae Open
Background: Carbapenemase-producing Enterobacteriaceae (CPE) are a major public health concern because they typically display multidrug resistance and they cause hard-to-treat infections. Organisms harboring metallo-β-lactamases (MBLs) pos…