Angela M. Kavanagh
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View article: Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i> ATCC 43300 strain
Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i> ATCC 43300 strain Open
Background and objectives The increasing occurrence of MRSA clinical isolates harbouring reduced susceptibility to mainstay antibiotics has escalated the use of second and last line antibiotics. Hence, it is critical to evaluate the likeli…
View article: Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i>
Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i> Open
SYNOPSIS Background The increasing occurrence of MRSA clinical isolates harbouring reduced susceptibility to mainstay antibiotics has escalated the use of second and last line antibiotics. Hence, it is critical to evaluate the likelihood o…
View article: Standardisation of high throughput microdilution antifungal susceptibility testing for Candida albicans and Cryptococcus neoformans
Standardisation of high throughput microdilution antifungal susceptibility testing for Candida albicans and Cryptococcus neoformans Open
The Clinical and Laboratory Standards Institute (CLSI) M27 guidelines are the recommended and most commonly used protocols for broth microdilution antifungal susceptibility testing of yeasts. However, these guidelines are limited to the us…
View article: Standardisation of high throughput microdilution antifungal susceptibility testing for Candida albicans and Cryptococcus neoformans
Standardisation of high throughput microdilution antifungal susceptibility testing for Candida albicans and Cryptococcus neoformans Open
The Clinical and Laboratory Standards Institute (CLSI) M27 guidelines are the recommended and most commonly used protocols for broth microdilution antifungal susceptibility testing of yeasts. However, these guidelines are limited to the us…
View article: The Antimicrobial Properties of Pd <sup>II</sup> − and Ru <sup>II</sup> −pyta Complexes**
The Antimicrobial Properties of Pd <sup>II</sup> − and Ru <sup>II</sup> −pyta Complexes** Open
Infections associated with antimicrobial resistance (AMR) are poised to become the leading cause of death in the next few decades, a scenario that can be ascribed to two phenomena: antibiotic over‐prescription and a lack of antibiotic drug…
View article: The antimicrobial properties of Pd(II)- and Ru(II)-pyta complexes
The antimicrobial properties of Pd(II)- and Ru(II)-pyta complexes Open
Infections associated with antimicrobial resistance (AMR) are poised to become the leading cause of death in the next few decades, a scenario that can be ascribed to two phenomena: antibiotic over-prescription and a lack of antibiotic drug…
View article: The antimicrobial potential of cannabidiol
The antimicrobial potential of cannabidiol Open
Antimicrobial resistance threatens the viability of modern medicine, which is largely dependent on the successful prevention and treatment of bacterial infections. Unfortunately, there are few new therapeutics in the clinical pipeline, par…
View article: In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria
In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria Open
Acne is a common skin affliction that involves excess sebum production and modified lipid composition, duct blockage, colonization by bacteria, and inflammation. Acne drugs target one or more of these steps, with antibiotics commonly used …
View article: Effects of Microplate Type and Broth Additives on Microdilution MIC Susceptibility Assays
Effects of Microplate Type and Broth Additives on Microdilution MIC Susceptibility Assays Open
The determination of antibiotic potency against bacterial strains by assessment of their minimum inhibitory concentration normally uses a standardized broth microdilution assay procedure developed more than 50 years ago. However, certain a…
View article: Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria Open
The public health threat posed by a looming ‘post-antibiotic’ era necessitates new approaches to antibiotic discovery. Drug development has typically avoided exploitation of membrane-binding properties, in contrast to nature’s control of b…
View article: Semi‐synthesis and NMR spectral assignments of flavonoid and chalcone derivatives
Semi‐synthesis and NMR spectral assignments of flavonoid and chalcone derivatives Open
Previous investigations of the aerial parts of the Australian plant Eremophila microtheca and Syzygium tierneyanum resulted in the isolation of the antimicrobial flavonoid jaceosidin ( 4 ) and 2′,6′‐dihydroxy‐4′‐methoxy‐3′,5′‐dimethyl chal…
View article: Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides
Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides Open
Bacteria have acquired extensive resistance mechanisms to protect themselves against antibiotic action. Today the bacterial membrane has become one of the "final frontiers" in the search for new compounds acting on novel targets to address…
View article: Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B Open
The polymyxin lipodecapeptides colistin and polymyxin B have become last resort therapies for infections caused by highly drug-resistant Gram-negative bacteria. Unfortunately, their utility is compromised by significant nephrotoxicity and …
View article: Mucin Binding Reduces Colistin Antimicrobial Activity
Mucin Binding Reduces Colistin Antimicrobial Activity Open
Colistin has found increasing use in treating drug-resistant bacterial lung infections, but potential interactions with pulmonary biomolecules have not been investigated. We postulated that colistin, like aminoglycoside antibiotics, may bi…