Explanipedia

IMPACTO DA HIPERTENSÃO ARTERIAL NA MORTALIDADE POR COVID-19 ENTRE IDOSOS NO MARANHÃO: ESTUDO OBSERVACIONAL Open

Paulina Almeida Rodrigues, Leonor Gomes, L Brandão Alves, Rafael José Holanda, Bruna Bessigo de Sá , et al. · 2025

PERFIL CLÍNICO-EPIDEMIOLÓGICO DA DENGUE EM UMA CIDADE DO NORDESTE DO BRASIL Open

Paulina Almeida Rodrigues, Bruna dos Santos Rodrigues, Ana Paula Santos, Gabriel Silva, Gabriela Nogueira Carvalho Maia , et al. · 2025

Análise dos efeitos da suplementação de creatina em pacientes com insuficiência cardíaca: Uma revisão integrativa Open

Wilson Marques, Leonor Gomes, Ana L. Chies-Santos, LUIS EDUARDO AGUIAR PONTE, Raimundo N. M. de Oliveira , et al. · 2025

A insuficiência cardíaca (IC) é uma síndrome complexa caracterizada pela incapacidade do coração de suprir adequadamente as necessidades metabólicas do organismo. A suplementação de creatina tem sido investigada como uma potencial estratég…

A EDUCAÇÃO PARA MULHERES NOS ESPAÇOS PRISIONAIS: UM DIREITO HUMANO Open

Leonor Gomes, João Diogenes Ferreira Dos Santos · 2024

A educação é um direito social, expresso pela Constituição Federal de 1988, pela Lei de Execução Penal (1984) e reafirmado pela Lei de Diretrizes e Bases da Educação (1996). Embora o direito à educação seja garantido pela legislação brasil…

Diabetes and Stroke: Impact of Novel Therapies for the Treatment of Type 2 Diabetes Mellitus Open

Inês Vieira, Tânia Carvalho, Joana Saraiva, Leonor Gomes, Isabel Paiva · 2024

Type 2 diabetes mellitus (T2DM) is a significant risk factor for stroke. Nevertheless, the evidence supporting stringent glycemic control to reduce macrovascular complications, particularly stroke, is not as clear as for microvascular comp…

Irreversible atrophy in memory brain regions over 7 years is predicted by glycemic control in type 2 diabetes without mild cognitive impairment Open

Nádia Canário, Joana Crisóstomo, João Valente Duarte, Carolina Moreno, Hugo Quental , et al. · 2024

Memory-related impairments in type 2 diabetes may be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control and a decrease in hippocampal v…

The hemodynamic response function as a type 2 diabetes biomarker: a data-driven approach Open

Pedro Guimarães, Pedro Serranho, João Valente Duarte, Joana Crisóstomo, Carolina Moreno , et al. · 2024

Introduction There is a need to better understand the neurophysiological changes associated with early brain dysfunction in Type 2 diabetes mellitus (T2DM) before vascular or structural lesions. Our aim was to use a novel unbiased data-dri…

Irreversible atrophy in memory brain regions over 7 years is predicted by glycemic control in type 2 diabetes without cognitive decline Open

Nádia Canário, Joana Crisóstomo, João Valente Duarte, Carolina Moreno, Hugo Quental , et al. · 2023

Memory-related impairments in type 2 diabetes maybe be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control and a decrease in hippocampal…

Regular physical activity moderates the adverse impact of type 2 diabetes on brain atrophy independently from HbA1c Open

Carolina Moreno, Otília C. d’Almeida, Leonor Gomes, Isabel Paiva, Miguel Castelo‐Branco · 2023

Objective Brain atrophy has been consistently associated with type 2 diabetes, beginning in early stages of dysglycemia, independently from micro and macrovascular complications. On the contrary, physical activity relates with larger brain…

Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes Open

João Valente Duarte, Catarina Guerra, Carolina Moreno, Leonor Gomes, Miguel Castelo‐Branco · 2023

Type 2 Diabetes Mellitus (T2DM) is a metabolic disease that leads to multiple vascular complications with concomitant changes in human neurophysiology, which may lead to long-term cognitive impairment, and dementia. Early impairments of ne…

Functional Ovarian Reserve in Women With Infertility and Euthyroidism: What Is the Role of Thyroid Autoimmunity? Open

Diana Festas Silva, Tânia Carvalho, Leonor Gomes, Isabel Paiva, Paulo Cortesão , et al. · 2021

Background: Thyroid dysfunction is the most common endocrine disorder in women of childbearing age, and is associated with menstrual irregularities, anovulation and infertility. Whether it is thyroid function, thyroid autoimmunity (AI) or …

A novel morphometric signature of brain alterations in type 2 diabetes: Patterns of changed cortical gyrification Open

Joana Crisóstomo, João Valente Duarte, Carolina Moreno, Leonor Gomes, Miguel Castelo‐Branco · 2021

Type 2 diabetes is a chronic disease that creates atrophic signatures in the brain, including decreases of total and regional volume of grey matter, white matter and cortical thickness. However, there is a lack of studies assessing cortica…

A Novel Variant in the <i>CASR</i> Gene c.368T>Cp.(Leu123Ser) in a Case of Hypocalcemia Refractory to Standard Medical Therapy Open

Diana Festas da Silva, Adriana Lages, Joana Serra Caetano, Rita Cardoso, Isabel Dinis , et al. · 2021

Introduction: Hypoparathyroidism is characterized by low or inappropriately normal PTH production, hypocalcemia and hyperphosphatemia. Autosomal dominant hypocalcemia (ADH) type 1 is one of the genetic etiologies of this, caused by heteroz…

A novel morphometric signature of brain alterations in type 2 diabetes: patterns of changed cortical gyrification Open

Joana Crisóstomo, João Valente Duarte, Carolina Moreno, Leonor Gomes, Miguel Castelo‐Branco · 2021

Type 2 diabetes is a chronic disease that creates atrophic signatures in the brain, including decreases of total and regional volume of grey matter, white matter, and cortical thickness. However, there is a lack of studies assessing cortic…

The neurometabolic profiles of GABA and Glutamate as revealed by proton magnetic resonance spectroscopy in type 1 and type 2 diabetes Open

Otília C. d’Almeida, Inês R. Violante, Bruno Quendera, Carolina Moreno, Leonor Gomes , et al. · 2020

Glucose metabolism is pivotal for energy and neurotransmitter synthesis and homeostasis, particularly in Glutamate and GABA systems. In turn, the stringent control of inhibitory/excitatory tonus is known to be relevant in neuropsychiatric …

Intervalo de referência para 1,5 anidroglucitol e polimorfismos funcionais da região promotora do gene do receptor para produtos de glicação avançada (RAGE) em crianças e adolescentes portadores de diabetes mellitus tipo 1 Open

Leonor Gomes · 2020

Erratum to “Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism” Open

Ana Paula Santos, João Vinagre, Paula Soares, Isabel Claro, A. Sanches , et al. · 2020

[This corrects the article DOI: 10.1155/2019/4518742.].

Corticotroph adenoma and pituitary fungal infection: a rare association Open

Diana Catarino, Cristina Ribeiro, Leonor Gomes, Isabel Paiva · 2020

Summary Pituitary infections, particularly with fungus, are rare disorders that usually occur in immunocompromised patients. Cushing’s syndrome predisposes patients to infectious diseases due to their immunosuppression status. We report th…

Maturity-Onset Diabetes of the Young (MODY) in Portugal: Novel GCK, HNFA1 and HNFA4 Mutations Open

Maria Inês Alvelos, Catarina Gonçalves, Eduarda Coutinho, Joana T. Almeida, Margarida Bastos , et al. · 2020

Maturity-onset diabetes of the young (MODY) is a frequently misdiagnosed type of diabetes, which is characterized by early onset, autosomal dominant inheritance, and absence of insulin dependence. The most frequent subtypes are due to muta…

Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism Open

Ana Paula Santos, João Vinagre, Paula Soares, Isabel Claro, A. Sanches , et al. · 2019

Background . The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been increasing in the last five decades, but there is no large-scale data regarding these tumours in Portugal. We conducted a cross-sectional, mu…

Challenging diagnosis of resistance to thyroid hormone in a patient with pituitary adenoma Open

Nelson Carvalho Cunha, Leonor Gomes, Margarida Bastos · 2019

The elevation of thyroid hormone with a normal or elevated thyroid-stimulation hormone (TSH) occurs uncommonly. This set a diagnosis challenge between TSH-secreting pituitary adenoma and resistance to thyroid hormone (RTH). We report a cas…

Interleukin-6 Producing Pheochromocytoma: A Rare Cause of Systemic Inflammatory Response Syndrome Open

Nelson Carvalho Cunha, Leonor Gomes, Joana Saraiva, Isabel Paiva · 2019

Systemic inflammatory response syndrome (SIRS) can be a rare manifestation of pheochromocytoma, since this adrenal tumor may produce cytokines and other hormones or neuropeptides besides catecholamines. We report the case of a 53-year-old …

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome Open

Mara Ventura, Leonor Gomes, Joana Rosmaninho‐Salgado, Luísa Barros, Isabel Paiva , et al. · 2019

Summary Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma a…

Impacto do Uso Prolongado da Terapêutica Subcutânea Contínua com Insulina no Controlo da Diabetes Mellitus Tipo 1 Open

Sergio Vicente de Azevedo, Joana Saraiva, Francisco Caramelo, Lúcia Fadiga, Luísa Barros , et al. · 2019

Introdução: O uso da terapêutica com perfusão subcutânea contínua de insulina na diabetes mellitus tipo 1 é cada vez mais frequente devido aos seus efeitos benéficos no controlo glicémico e na flexibilidade do estilo de vida. Constituiu ob…

Banting and Best: The Extraordinary Discovery of Insulin Open

Luís Cardoso, Dírcea Rodrigues, Leonor Gomes, Francisco Carrilho · 2017

Diabetes was a feared disease that most certainly led to death before insulin discovery. During the first two decades of the 20th century, several researchers tested pancreatic extracts, but most of them caused toxic reactions impeding hum…

Innapropriate TSH secretion: the challenging diagnosis Open

Nelson Carvalho Cunha, Leonor Gomes, Cardoso Luís, Nuno Vicente, Diana Martins , et al. · 2016

Background. The elevation of thyroid hormone with a normal or elevated TSH occurs uncommonly. This has different causes and pose a diagnosis challenge namely between TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormon…

Clinical, imaging and cytological differences between palpable and non-palpable thyroid nodules Open

João Silva, Sandra Paiva, Cristina Ribeiro, Miguel Melo, Leonor Gomes , et al. · 2016

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Prolactina e metabolismo – uma perspetiva diferente de uma hormona multifuncional Open

Daniela Guelho, Leonor Gomes, Isabel Paiva, Francisco Carrilho · 2016

A prolactina apresenta características moleculares e fisiológicas únicas, que lhe permitem desempenhar inúmeras funções. Além do seu papel na lactação e na regulação da função reprodutiva, esta hormona influencia múltiplos processos biológ…

Relations between Cardiac and Visual Phenotypes in Diabetes: A Multivariate Approach Open

Bárbara Oliveiros, Mafalda Sanches, Bruno Quendera, Bruno Graça, Daniela Guelho , et al. · 2016

Cardiovascular disease and diabetes represent a major public health concern. The former is the most frequent cause of death and disability in patients with type 2 diabetes, where left ventricular dysfunction is highly prevalent. Moreover, …

Early Disrupted Neurovascular Coupling and Changed Event Level Hemodynamic Response Function in Type 2 Diabetes: An fMRI Study Open

João Valente Duarte, João Pereira, Bruno Quendera, Miguel Raimundo, Carolina Moreno , et al. · 2015

Type 2 diabetes (T2DM) patients develop vascular complications and have increased risk for neurophysiological impairment. Vascular pathophysiology may alter the blood flow regulation in cerebral microvasculature, affecting neurovascular co…

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