Maria P. Kotini
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View article: Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1
Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1 Open
De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces, yet the underlying mechanisms remain unclear. Using a zebrafish model, we develop a series of molecular reporters, photo-convertible …
View article: Initiation of Lumen Formation from Junctions via Differential Actomyosin Contractility Regulated by Dynamic Recruitment of Rasip1
Initiation of Lumen Formation from Junctions via Differential Actomyosin Contractility Regulated by Dynamic Recruitment of Rasip1 Open
Vascular lumens are essential for the dispersal of nutrients, oxygen, and immune cells throughout the body. De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces. Direct visualization of t…
View article: Genetic analysis of<i>rab7</i>mutants in zebrafish
Genetic analysis of<i>rab7</i>mutants in zebrafish Open
Vascular network formation requires the fusion of newly formed blood vessels and the emergence of a patent lumen between the newly established connections so that blood flow can start. Lumen formation has been shown to depend on the late e…
View article: Interferon-γ drives macrophage reprogramming, cerebrovascular remodelling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload
Interferon-γ drives macrophage reprogramming, cerebrovascular remodelling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload Open
Aims Dysregulated immune response contributes to inefficiency of treatment strategies to control hypertension and reduce the risk of end-organ damage. Uncovering the immune pathways driving the transition from the onset of hypertensive sti…
View article: Vinculin strengthens the endothelial barrier during vascular development
Vinculin strengthens the endothelial barrier during vascular development Open
Remodelling of cell–cell junctions is crucial for proper tissue development and barrier function. The cadherin-based adherens junctions anchor via β-catenin and α-catenin to the actomyosin cytoskeleton, together forming a junctional mechan…
View article: Vinculin controls endothelial cell junction dynamics during vascular lumen formation
Vinculin controls endothelial cell junction dynamics during vascular lumen formation Open
Blood vessel morphogenesis is driven by coordinated endothelial cell behaviors. Active remodeling of cell-cell junctions promotes cellular plasticity while preserving vascular integrity. Here, we analyze the dynamics of endothelial adheren…
View article: Vinculin controls endothelial cell junction dynamics during vascular lumen formation
Vinculin controls endothelial cell junction dynamics during vascular lumen formation Open
Blood vessel morphogenesis is driven by coordinated endothelial cell behaviors, which depend on dynamic cell-cell interactions. Remodeling of endothelial cell-cell junctions promote morphogenetic cellular events while preserving vascular i…
View article: Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos
Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos Open
Angiogenesis is a fundamental developmental process and a hallmark of cancer progression. Receptor tyrosine kinases (RTK) are targets for cancer therapy which may include their action as anti-angiogenic agents. Derazantinib (DZB) is an inh…
View article: Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: similarities and differences in cell behaviour
Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: similarities and differences in cell behaviour Open
Branching morphogenesis is a fascinating process whereby a simple network of biological tubes increases its complexity by adding new branches to existing ones, generating an enlarged structure of interconnected tubes. Branching morphogenes…
View article: Author Correction: Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Author Correction: Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo Open
The original version of this Article contained an error in the spelling of the author Alexandra Schambony, which was incorrectly given as Alexandra Schambon. This has now been corrected in both the PDF and HTML versions of the Article.
View article: Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo Open
Connexins are the primary components of gap junctions, providing direct links between cells under many physiological processes. Here, we demonstrate that in addition to this canonical role, Connexins act as transcriptional regulators. We s…
View article: Connexin43 controls N-cadherin transcription during collective cell migration
Connexin43 controls N-cadherin transcription during collective cell migration Open
Connexins are the primary components of gap junctions, providing direct links between cells in many physiological processes, including cell migration and cancer metastasis. Exactly how cell migration is controlled by gap junctions remains …