Maria Pachetti
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View article: Extracellular vesicles released by LPS-stimulated spinal organotypic slices spread neuroinflammation into naïve slices through connexin43 hemichannel opening and astrocyte aberrant calcium dynamics
Extracellular vesicles released by LPS-stimulated spinal organotypic slices spread neuroinflammation into naïve slices through connexin43 hemichannel opening and astrocyte aberrant calcium dynamics Open
Introduction Neuroinflammation is a hallmark of multiple neurodegenerative diseases, shared by all pathological processes which primarily impact on neurons, including Central Nervous System (CNS) injuries. In reactive CNS, activated glia r…
View article: Exploring Ca<sup>2+</sup>Dynamics in Myelinating Oligodendrocytes through rAAV-Mediated jGCaMP8s Expression in Developing Spinal Cord Organ Cultures
Exploring Ca<sup>2+</sup>Dynamics in Myelinating Oligodendrocytes through rAAV-Mediated jGCaMP8s Expression in Developing Spinal Cord Organ Cultures Open
Oligodendrocytes, the myelin-producing glial cells of the central nervous system (CNS), crucially contribute to myelination and circuit function. An increasing amount of evidence suggests that intracellular calcium (Ca 2+ ) dynamics in oli…
View article: Evaluation of self-sampling-based cervical cancer screening strategy using HPV Selfy CE-IVD test coupled with home-collection kit: a clinical study in Italy
Evaluation of self-sampling-based cervical cancer screening strategy using HPV Selfy CE-IVD test coupled with home-collection kit: a clinical study in Italy Open
View article: Correction: Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples
Correction: Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples Open
HPV Selfy clinical sensitivity and specificity resulted non-inferior to those of HC2. By analysis of a total of 889 cervical liquid-based cytology samples from a screening population, of which 98 were from women with CIN2+, HPV Selfy showe…
View article: Detention and mapping of iron and toxic environmental elements in human ovarian endometriosis: A suggested combined role
Detention and mapping of iron and toxic environmental elements in human ovarian endometriosis: A suggested combined role Open
μXRF reveals accumulation and colocalization of iron and environmental metals in human ovarian endometriosis, suggesting a role in the pathogenesis of endometriosis.
View article: Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples
Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples Open
View article: Strategies and Perspectives for UV Resonance Raman Applicability in Clinical Analyses of Human Sperm RNA
Strategies and Perspectives for UV Resonance Raman Applicability in Clinical Analyses of Human Sperm RNA Open
Developing a deeper knowledge about the impact of DNA and RNA epigenetic mutations on sperm production and fertilization performance is essential for selecting best quality samples in Assisted Reproductive Technologies (ART). Indeed, sperm…
View article: UV Resonance Raman explores protein structural modification upon fibrillation and ligand interaction
UV Resonance Raman explores protein structural modification upon fibrillation and ligand interaction Open
View article: Specific Interactions and Environment Flexibility Tune Protein Stability under Extreme Crowding
Specific Interactions and Environment Flexibility Tune Protein Stability under Extreme Crowding Open
Macromolecular crowding influences protein mobility and stability in vivo. A precise description of the crowding effect on protein thermal stability requires the estimate of the combined effects of excluded volume, specific protein-…
View article: Shedding plasma membrane vesicles induced by graphene oxide nanoflakes in brain cultured astrocytes
Shedding plasma membrane vesicles induced by graphene oxide nanoflakes in brain cultured astrocytes Open
Microvesicles (MVs) generated and released by astrocytes, the brain prevalent cells, crucially contribute to intercellular communication, representing key vectorized systems able to spread and actively transfer signaling molecules from ast…
View article: FTIR Spectroscopy to Reveal Lipid and Protein Changes Induced on Sperm by Capacitation: Bases for an Improvement of Sample Selection in ART
FTIR Spectroscopy to Reveal Lipid and Protein Changes Induced on Sperm by Capacitation: Bases for an Improvement of Sample Selection in ART Open
Although being a crucial step for Assisted Reproduction Technologies (ART) success, to date sperm selection is based only on morphology, motility and concentration characteristics. Considering the many possible alterations, there is a grea…
View article: Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America
Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America Open
Background Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbreak has been declared…
View article: Impact of lockdown on Covid-19 Case Fatality Rate and Viral Mutations Spread in 7 Countries in Europe and North America.
Impact of lockdown on Covid-19 Case Fatality Rate and Viral Mutations Spread in 7 Countries in Europe and North America. Open
Background: Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbreak has been declare…
View article: Investigation of genomic <scp>DNA</scp> methylation by ultraviolet resonant Raman spectroscopy
Investigation of genomic <span>DNA</span> methylation by ultraviolet resonant Raman spectroscopy Open
Cytosine plays a preeminent role in DNA methylation, an epigenetic mechanism that regulates gene expression, the misregulation of which can lead to severe diseases. Several methods are nowadays employed for assessing the global DNA methyla…
View article: SARS‐CoV‐2: March toward adaptation
SARS‐CoV‐2: March toward adaptation Open
The worldwide spread of severe acute respiratory syndrome cor-onavirus 2 (SARS-CoV-2), the novel human pathogen, first detectedin China quickly became a global health emergency, culminating withthe World Health Organization publicly procla…
View article: Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas Open
View article: Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas.
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas. Open
Background With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and population density, with d…
View article: Impact of lockdown on Covid-19 Case Fatality Rate and Viral Mutations Spread.
Impact of lockdown on Covid-19 Case Fatality Rate and Viral Mutations Spread. Open
Background Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbreak has been declared…
View article: Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas.
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas. Open
Background With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and population density, with d…
View article: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant Open
Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts. Viru…
View article: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant Open
Background. SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts. Vir…
View article: Galvanic Replacement Reaction as a Route to Prepare Nanoporous Aluminum for UV Plasmonics
Galvanic Replacement Reaction as a Route to Prepare Nanoporous Aluminum for UV Plasmonics Open
There is a growing interest in extending plasmonics applications into the ultraviolet region of the electromagnetic spectrum. Noble metals are commonly used in plasmonic, but their intrinsic optical properties limit their use above 350 nm.…
View article: Galvanic Replacement Reaction to prepare nanoporous Aluminum for UV plasmonics
Galvanic Replacement Reaction to prepare nanoporous Aluminum for UV plasmonics Open
Plasmonics applications have been extending into the ultraviolet region of the electromagnetic spectrum. Unfortunately the commonly used noble metals have intrinsic optical properties that limit their use above 350 nm. Aluminum is probably…
View article: Critical structural fluctuations of proteins upon thermal unfolding challenge the Lindemann criterion
Critical structural fluctuations of proteins upon thermal unfolding challenge the Lindemann criterion Open
Significance In 1910 F. A. Lindemann introduced a practical criterion to predict the melting of crystals on the basis of the relative magnitude of thermal atomic fluctuations and the crystal lattice constant. The idea of a critical thresho…