María Paula Zappia
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View article: Medium-Chain Fatty Acid exposure in non-transformed mammary glands leads to pro-tumorigenic alterations associated with aging
Medium-Chain Fatty Acid exposure in non-transformed mammary glands leads to pro-tumorigenic alterations associated with aging Open
The local breast environment is a valuable research focus for identifying the etiological and biological factors that contribute to the development of breast cancer. Single-cell RNA sequencing shows that the increased availability of the m…
View article: A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells Open
Lipid metabolism and the serine, one-carbon, glycine (SOG) and methionine pathways are independently and significantly correlated with estrogen receptor–negative breast cancer (ERneg BC). Here, we propose a link between lipid metabolism an…
View article: The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila
The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila Open
Robust genetic systems to control the expression of transgenes in a spatial and temporal manner are a valuable asset for researchers. The GeneSwitch system induced by the drug RU486 has gained widespread use in the Drosophila community. Ho…
View article: <sub>Metabolic</sub>shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells
<sub>Metabolic</sub>shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells Open
A lipid metabolism gene signature is associated with the risk of estrogen negative breast cancer (ER-BC). In vitro, lipid exposure alters histone methylation affecting gene expression and increasing flux through various metabolic reactions…
View article: C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita
C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita Open
Introduction Inflammatory epidermolysis bullosa acquisita (EBA) is characterized by a neutrophilic response to anti-type VII collagen (COL7) antibodies resulting in the development of skin inflammation and blistering. The antibody transfer…
View article: The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila
The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila Open
Robust genetic systems to control the expression of transgenes in a spatial and temporal manner are a valuable asset for researchers. The GeneSwitch system induced by the drug RU486 has gained widespread use in the Drosophila community. Ho…
View article: E2F regulation of the <i>Phosphoglycerate kinase</i> gene is functionally important in <i>Drosophila</i> development
E2F regulation of the <i>Phosphoglycerate kinase</i> gene is functionally important in <i>Drosophila</i> development Open
The canonical role of the transcription factor E2F is to control the expression of cell cycle genes by binding to the E2F sites in their promoters. However, the list of putative E2F target genes is extensive and includes many metabolic gen…
View article: Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer Open
The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates with CBP to activate transcription and with Rb to repress transcription. Although the…
View article: Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer Open
Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
View article: Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer Open
The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates with CBP to activate transcription and with Rb to repress transcription. Although the…
View article: Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer Open
Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
View article: The binding sites of E2F transcription factor in<i>Drosophila</i>metabolic genes are functionally distinct
The binding sites of E2F transcription factor in<i>Drosophila</i>metabolic genes are functionally distinct Open
The canonical role of the transcription factor E2F is to control the expression of cell cycle genes by binding to the E2F sites in their promoters. However, the list of putative E2F target genes is extensive and includes many metabolic gen…
View article: Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer Open
The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates with CBP to activate transcription and with Rb to repress transcription. Although the…
View article: E2F/Dp inactivation in fat body cells triggers systemic metabolic changes
E2F/Dp inactivation in fat body cells triggers systemic metabolic changes Open
The E2F transcription factors play a critical role in controlling cell fate. In Drosophila , the inactivation of E2F in either muscle or fat body results in lethality, suggesting an essential function for E2F in these tissues. However, the…
View article: Author response: E2F/Dp inactivation in fat body cells triggers systemic metabolic changes
Author response: E2F/Dp inactivation in fat body cells triggers systemic metabolic changes Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The E2F transcription factors play a criti…
View article: E2F/Dp inactivation in fat body cells triggers systemic metabolic changes
E2F/Dp inactivation in fat body cells triggers systemic metabolic changes Open
The E2F transcription factors play a critical role in controlling cell fate. In Drosophila , the inactivation of E2F in either muscle or fat body results in lethality, suggesting an essential function for E2F in these tissues. However, the…
View article: A cell atlas of adult muscle precursors uncovers early events in fibre‐type divergence in <i>Drosophila</i>
A cell atlas of adult muscle precursors uncovers early events in fibre‐type divergence in <i>Drosophila</i> Open
View article: A single-cell transcriptome atlas of the adult muscle precursors uncovers early events in fiber-type divergence in<i>Drosophila</i>
A single-cell transcriptome atlas of the adult muscle precursors uncovers early events in fiber-type divergence in<i>Drosophila</i> Open
Summary In Drosophila , the wing disc-associated adult muscle precursors (AMPs) give rise to the fibrillar indirect flight muscles (IFM) and the tubular direct flight muscles (DFM). To understand early transcriptional events underlying thi…
View article: Rbf Activates the Myogenic Transcriptional Program to Promote Skeletal Muscle Differentiation
Rbf Activates the Myogenic Transcriptional Program to Promote Skeletal Muscle Differentiation Open
View article: Single cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant
Single cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant Open
View article: E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression
E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression Open
View article: E2F function in muscle growth is necessary and sufficient for viability in Drosophila
E2F function in muscle growth is necessary and sufficient for viability in Drosophila Open