Maria Plesia
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View article: In Vivo Raman Spectroscopy of Muscle Is Highly Sensitive for Detection of Healthy Muscle and Highly Specific for Detection of Disease
In Vivo Raman Spectroscopy of Muscle Is Highly Sensitive for Detection of Healthy Muscle and Highly Specific for Detection of Disease Open
Raman spectroscopy of muscle provides a molecular fingerprint to identify the disease. Previous work has demonstrated effectiveness in differentiating between two groups of equal sizes (e.g., healthy vs disease) but imbalanced multiclass s…
View article: Conformational fingerprinting with Raman spectroscopy reveals protein structure as a translational biomarker of muscle pathology
Conformational fingerprinting with Raman spectroscopy reveals protein structure as a translational biomarker of muscle pathology Open
Using a combination of peak fitting and matrix factorisation techniques we show that neuromuscular disease in both human biopsies and preclinical models manifests alterations in protein secondary structure. Created with biorender.com.
View article: Combining <scp>electromyography</scp> and Raman spectroscopy: optical EMG
Combining <span>electromyography</span> and Raman spectroscopy: optical EMG Open
Introduction/Aims Electromyography (EMG) remains a key component of the diagnostic work‐up for suspected neuromuscular disease, but it does not provide insight into the molecular composition of muscle which can provide diagnostic informati…
View article: Non‐negative matrix factorisation of Raman spectra finds common patterns relating to neuromuscular disease across differing equipment configurations, preclinical models and human tissue
Non‐negative matrix factorisation of Raman spectra finds common patterns relating to neuromuscular disease across differing equipment configurations, preclinical models and human tissue Open
Raman spectroscopy shows promise as a biomarker for complex nerve and muscle (neuromuscular) diseases. To maximise its potential, several challenges remain. These include the sensitivity to different instrument configurations, translation …
View article: Fiber optic Raman spectroscopy for the evaluation of disease state in Duchenne muscular dystrophy: An assessment using the <i>mdx</i> model and human muscle
Fiber optic Raman spectroscopy for the evaluation of disease state in Duchenne muscular dystrophy: An assessment using the <i>mdx</i> model and human muscle Open
Introduction/Aims Raman spectroscopy is an emerging technique for the evaluation of muscle disease. In this study we evaluate the ability of in vivo intramuscular Raman spectroscopy to detect the effects of voluntary running in the mdx mod…
View article: Rapid identification of human muscle disease with fibre optic Raman spectroscopy
Rapid identification of human muscle disease with fibre optic Raman spectroscopy Open
We demonstrate the use of fibre optic Raman spectroscopy for the rapid identification of muscle disorders.
View article: <i>In Vivo</i> Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy
<i>In Vivo</i> Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy Open
Neuromuscular diseases result in muscle weakness, disability, and, in many instances, death. Preclinical models form the bedrock of research into these disorders, and the development of in vivo and potentially translational biomarke…