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View article: Biocompatible and Biodegradable Plant-Based Burn Dressings: A Sustainable Approach for Skin Regeneration
Biocompatible and Biodegradable Plant-Based Burn Dressings: A Sustainable Approach for Skin Regeneration Open
Traditional biomedical products often utilize petroleum-based polymers, contributing to long-term environmental pollution due to their nonbiodegradable nature. In response, this study introduces a novel class of sustainable, eco-friendly s…
View article: Electrodeposited Functional Coatings for On-Demand Electro-Responsive Drug Release and Cell Shape Transformation
Electrodeposited Functional Coatings for On-Demand Electro-Responsive Drug Release and Cell Shape Transformation Open
Chronic wounds affect millions of people worldwide and their treatment can often be ineffective, resulting in substantial healthcare costs. Due to their prolonged healing time and susceptibility to infections, their treatment can be comple…
View article: Active Biopaste for Coral Reef Restoration
Active Biopaste for Coral Reef Restoration Open
Preserving coral reefs is crucial for safeguarding marine biodiversity, global ecosystems, and coastal communities. Coral restoration focuses on farming and transplanting corals back onto reefs. However, traditional attachment methods, suc…
View article: Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies Open
Bipolar disorder is a complex neuropsychiatric condition with a significant unmet medical need, as current treatments lack disease-modifying properties and multimodal therapeutic effects. To overcome the limitations of single-target drugs,…
View article: Zein spray-dried microparticles loaded with chemically modified curcumin for active wound healing
Zein spray-dried microparticles loaded with chemically modified curcumin for active wound healing Open
Wound healing is a delicate process comprising various phases, of which inflammation constitutes the most critical one, as some wounds fail to evolve from this state due to pre-existing pathologies or medical conditions, becoming chronic a…
View article: Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy Open
We previously reported trisubstituted pyrimidine lead compounds, namely, ARN22089 and ARN25062, which block the interaction between CDC42 with its specific downstream effector, a PAK protein. This interaction is crucial for the progression…
View article: CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo
CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo Open
Tumors that arise in the epidermis must develop a vascular supply to grow beyond a millimeter in depth. This process requires CDC42 GTPases such as CDC42, RhoJ and RhoQ. Despite this dependence on angiogenesis for growth, melanoma tumors a…
View article: Electrosprayed zein nanoparticles as antibacterial and anti-thrombotic coatings for ureteral stents
Electrosprayed zein nanoparticles as antibacterial and anti-thrombotic coatings for ureteral stents Open
Ureteral stents are among the most frequently used human implants, with urothelium trauma, blood clots, and bacterial colonization being their main reasons for failure. In this study, berberine-loaded zein (ZB) nanoparticles with high drug…
View article: Combining Alginate/PVPI‐Based Film with Frequency Rhythmic Electrical Modulation System (FREMS) Technology as an Advanced Strategy for Diabetic Wounds
Combining Alginate/PVPI‐Based Film with Frequency Rhythmic Electrical Modulation System (FREMS) Technology as an Advanced Strategy for Diabetic Wounds Open
Diabetes is rising as one of the most diffused diseases of the century with the related urgent necessity to face its systemic and local effects on the patients, such as cardiovascular problems, degeneration of limbs, and dysfunction of the…
View article: Plant-Based, Hydrogel-like Microfibers as an Antioxidant Platform for Skin Burn Healing
Plant-Based, Hydrogel-like Microfibers as an Antioxidant Platform for Skin Burn Healing Open
Natural polymers from organic wastes have gained increasing attention in the biomedical field as resourceful second raw materials for the design of biomedical devices which can perform a specific bioactive function and eventually degrade w…
View article: Design, Synthesis, <i>In Vitro</i> and <i>In Vivo</i> Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
Design, Synthesis, <i>In Vitro</i> and <i>In Vivo</i> Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer Open
CDC42 GTPases (RHOJ, CDC42, and RHOQ) are overexpressed in multiple tumor types and activate pathways critical for tumor growth, angiogenesis, and metastasis. Recently, we reported the discovery of a novel lead compound, ARN22089, which bl…
View article: Copper nano-architecture topical cream for the accelerated recovery of burnt skin
Copper nano-architecture topical cream for the accelerated recovery of burnt skin Open
This study demonstrates the potential of copper nanotechnology for the topical treatment of burn injuries and opens new horizons in oncological dermatology.
View article: Dynamic investigation of zein-based degradable and hemocompatible coatings for drug-eluting stents: a microfluidic approach
Dynamic investigation of zein-based degradable and hemocompatible coatings for drug-eluting stents: a microfluidic approach Open
Microfluidic-based dynamic assays for drug-eluting stent coatings.
View article: The Fate of Intranasally Instilled Silver Nanoarchitectures
The Fate of Intranasally Instilled Silver Nanoarchitectures Open
The intranasal administration of drugs allows an effective and noninvasive therapeutic action on the respiratory tract. In an era of rapidly increasing antimicrobial resistance, new approaches to the treatment of communicable diseases, esp…
View article: Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance Open
Prion diseases are a group of neurodegenerative disorders characterized by the accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular prion protein (PrPC) to PrPSc is still not completely understood, mo…
View article: Self-Adhesive and Antioxidant Poly(vinylpyrrolidone)/Alginate-Based Bilayer Films Loaded with <i>Malva sylvestris</i> Extracts as Potential Skin Dressings
Self-Adhesive and Antioxidant Poly(vinylpyrrolidone)/Alginate-Based Bilayer Films Loaded with <i>Malva sylvestris</i> Extracts as Potential Skin Dressings Open
Malva sylvestris (MS) is a medicinal herb known worldwide for its beneficial effects due to the several active molecules present in its leaves and flowers. These compounds have shown antioxidant and anti-inflammatory properties and thus ca…
View article: Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer Open
CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here, we use comput…
View article: Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer Open
CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here, we use comput…
View article: Evaluation of a Multifunctional Polyvinylpyrrolidone/Hyaluronic Acid-Based Bilayer Film Patch with Anti-Inflammatory Properties as an Enhancer of the Wound Healing Process
Evaluation of a Multifunctional Polyvinylpyrrolidone/Hyaluronic Acid-Based Bilayer Film Patch with Anti-Inflammatory Properties as an Enhancer of the Wound Healing Process Open
The management of acute and chronic wounds is still a socioeconomic burden for society due to the lack of suitable tools capable of supporting all the healing phases. The exponential spread of diabetes worldwide and the consequent increase…
View article: Structure-based Design of CDC42 Effector Interaction Inhibitors For the Treatment of Cancer
Structure-based Design of CDC42 Effector Interaction Inhibitors For the Treatment of Cancer Open
SUMMARY CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial cells to vascularize tumors. Here we use…
View article: Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration Open
Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanola…
View article: Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review
Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review Open
Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are local…
View article: Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors
Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors Open
Acid ceramidase (AC) is a cysteine hydrolase that plays a crucial role in the metabolism of lysosomal ceramides, important members of the sphingolipid family, a diversified class of bioactive molecules that mediate many biological processe…
View article: Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β Open
We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-targeted drugs currently in clinical use, these compounds do…
View article: Identification, Structure–Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1<i>H</i>-pyrido[4,3-<i>b</i>]indoles as a Novel Class of CFTR Potentiators
Identification, Structure–Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1<i>H</i>-pyrido[4,3-<i>b</i>]indoles as a Novel Class of CFTR Potentiators Open
Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address the basic defects associated w…