Maria Tomkins
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View article: Pituitary disorders in pregnancy
Pituitary disorders in pregnancy Open
The management of pituitary disorders in pregnancy presents a unique challenge for maternal medicine specialists and endocrinologists. Advances in assisted reproductive technologies (ART) mean that women with hypopituitarism are increasing…
View article: Systematic Review and Meta‐Analysis on the Prevalence of Radiotherapy‐Induced Hypopituitarism in Adults With Primary Non‐Pituitary Brain Tumours
Systematic Review and Meta‐Analysis on the Prevalence of Radiotherapy‐Induced Hypopituitarism in Adults With Primary Non‐Pituitary Brain Tumours Open
Context It is well recognised there is a high prevalence of pituitary dysfunction in childhood brain tumours survivors who are treated with radiotherapy. In contrast, the potential for survivors of brain tumours arising in adulthood to dev…
View article: Resistant hypertension post-transsphenoidal surgery for pituitary Cushing’s disease, leading to a diagnosis of primary aldosteronism
Resistant hypertension post-transsphenoidal surgery for pituitary Cushing’s disease, leading to a diagnosis of primary aldosteronism Open
Summary We describe a case of a 42-year-old gentleman, 5 years post-transsphenoidal surgery (TSS) for pituitary-dependent Cushing’s disease, initially presenting with malignant hypertension. Despite an initial improvement in his blood pres…
View article: Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Kidney Disease Disrupts 11-Oxygenated Androgen Biosynthesis
Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Kidney Disease Disrupts 11-Oxygenated Androgen Biosynthesis Open
Context 11-Oxygenated androgens are a group of adrenal-derived steroids that require peripheral activation. In vitro data highlight a putative role for 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) in 11-oxygenated androgen biosynthesi…
View article: Bladder Paraganglioma Presenting as Post-Micturition Syncope
Bladder Paraganglioma Presenting as Post-Micturition Syncope Open
A 22-year-old female presented with a twelve-year history of intensifying paroxysms of anxiety, palpitations and recurrent syncope following micturition. The patient was referred to endocrinology upon discovery of hypertension. Extended fa…
View article: Diagnosis and Management of Central Diabetes Insipidus in Adults
Diagnosis and Management of Central Diabetes Insipidus in Adults Open
Central diabetes insipidus (CDI) is a clinical syndrome which results from loss or impaired function of vasopressinergic neurons in the hypothalamus/posterior pituitary, resulting in impaired synthesis and/or secretion of arginine vasopres…
View article: Adrenal insufficiency is common amongst kidney transplant recipients receiving maintenance prednisolone and can be predicted using morning cortisol
Adrenal insufficiency is common amongst kidney transplant recipients receiving maintenance prednisolone and can be predicted using morning cortisol Open
Background Long-term glucocorticoid therapy is a key component of immunosuppression for kidney transplant recipients (KTRs), leading to significant cumulative glucocorticoid exposure. The aims of this study are to investigate the prevalenc…
View article: Approach to the Patient: Hyponatremia and the Syndrome of Inappropriate Antidiuresis (SIAD)
Approach to the Patient: Hyponatremia and the Syndrome of Inappropriate Antidiuresis (SIAD) Open
Hyponatremia is the most common electrolyte disturbance seen in clinical practice, affecting up to 30% of acute hospital admissions, and is associated with significant adverse clinical outcomes. Acute or severe symptomatic hyponatremia car…
View article: The Prevalence of Adrenal Insufficiency in Kidney Transplant Recipients
The Prevalence of Adrenal Insufficiency in Kidney Transplant Recipients Open
Long term glucocorticoid therapy is a key component of immunosuppression for kidney transplant recipients (KTR), leading to a significant cumulative glucocorticoid exposure in this cohort. However, assessment of adrenal function and steroi…
View article: Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis and agranulocytosis in a patient with Graves’ disease
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis and agranulocytosis in a patient with Graves’ disease Open
Summary This case is the first to describe a patient who experienced concomitant agranulocytosis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis as an adverse effect of propylthiouracil treatment for Graves’ disease. …
View article: Autonomic alterations as a clinical manifestation of encephalopathy associated with autoimmune thyroid disease
Autonomic alterations as a clinical manifestation of encephalopathy associated with autoimmune thyroid disease Open
Encephalopathy associated with autoimmune thyroid disease (EAATD), also known as Hashimoto's encephalopathy, is a rare neurological condition that may occur in patients with clinical or sub-clinical autoimmune thyroid disease. The pathogen…