Maria V. Sánchez‐Vives
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View article: Advancing the science of consciousness: From ethics to clinical care
Advancing the science of consciousness: From ethics to clinical care Open
Significant advances in the scientific investigation of the neurobiology of consciousness have been slow to be translated into clinical settings, limited by a lack of generally agreed working definition (e.g., what is consciousness?) and m…
View article: Slow waves generation and propagation in a model of brain lesions
Slow waves generation and propagation in a model of brain lesions Open
Slow waves (SWs), the hallmark of non-rapid eye movement (NREM) sleep, reflect the periodic occurrence of transient silent periods in cortical neurons (Down states). During NREM, SWs and Down states physiologically disrupt large-scale netw…
View article: Characterizing sleep stages through the complexity-entropy plane in human intracranial data and in a whole-brain model
Characterizing sleep stages through the complexity-entropy plane in human intracranial data and in a whole-brain model Open
Characterizing the brain dynamics during different cortical states can reveal valuable information about its patterns across various cognitive processes. In particular, studying the differences between awake and sleep stages can shed light…
View article: Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model
Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model Open
The human brain displays substantial regional variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shapes large-scale neuronal dynamics remains poorly understood. To address this question, we em…
View article: Riemannian Geometry for the Classification of Brain States with Intracortical Brain Recordings
Riemannian Geometry for the Classification of Brain States with Intracortical Brain Recordings Open
This study investigates the application of Riemannian geometry‐based methods for brain decoding using invasive electrophysiological recordings. While Riemannian geometry has been successfully applied in noninvasive settings, its utility fo…
View article: Multiscale dynamical characterization of cortical brain states: from synchrony to asynchrony
Multiscale dynamical characterization of cortical brain states: from synchrony to asynchrony Open
The cerebral cortex spontaneously displays different patterns of activity that evolve over time according to the brain state. Sleep, wakefulness, resting states, and attention are examples of a wide spectrum of physiological states that ca…
View article: Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo
Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo Open
View article: Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation
Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation Open
Understanding how brain stimulation interacts with the brain's internal dynamics is crucial for developing effective neuromodulation protocols. Here we explore the effects of exogenous alternating current (AC) fields across various amplitu…
View article: Neural models for detection and classification of brain states and transitions
Neural models for detection and classification of brain states and transitions Open
Exploring natural or pharmacologically induced brain dynamics, such as sleep, wakefulness, or anesthesia, provides rich functional models for studying brain states. These models allow detailed examination of unique spatiotemporal neural ac…
View article: Riemannian Geometry for the classification of brain states with intracortical brain-computer interfaces
Riemannian Geometry for the classification of brain states with intracortical brain-computer interfaces Open
This study investigates the application of Riemannian geometry-based methods for brain decoding using invasive electrophysiological recordings. Although previously employed in non-invasive, the utility of Riemannian geometry for invasive d…
View article: International initiatives for the study of the human brain: EBRAINS and its Spanish node
International initiatives for the study of the human brain: EBRAINS and its Spanish node Open
The present article provides an overview of the main global initiatives that have emerged around the human brain in the last century, the achievements made, the most relevant technological capabilities, in what aspects they differ from oth…
View article: Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro
Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro Open
Elucidating human cerebral cortex function is essential for understanding the physiological basis of both healthy and pathological brain states. We obtained extracellular local field potential recordings from slices of neocortical tissue f…
View article: Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands
Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands Open
Acetylcholine and the cholinergic system are crucial to brain function, including functions such as consciousness and cognition. Dysregulation of this system is implicated in the pathophysiology of neurological conditions such as Alzheimer…
View article: Enhancement and attenuation of brain oscillations by weak electric fields
Enhancement and attenuation of brain oscillations by weak electric fields Open
View article: The temporal asymmetry of cortical dynamics as a signature of brain states
The temporal asymmetry of cortical dynamics as a signature of brain states Open
The brain is a complex non-equilibrium system capable of expressing many different dynamics as well as the transitions between them. We hypothesized that the level of non-equilibrium can serve as a signature of a given brain state, which w…
View article: Sleep-like cortical dynamics during wakefulness and their network effects following brain injury
Sleep-like cortical dynamics during wakefulness and their network effects following brain injury Open
View article: A Novel 64/128-Channel Amplification System with Four Independent Bias Voltages for Recordings with Graphene Transistor Arrays
A Novel 64/128-Channel Amplification System with Four Independent Bias Voltages for Recordings with Graphene Transistor Arrays Open
In neural engineering, improving neuroelectronic interfaces for enhanced spatial resolution and sensitivity remains a significant challenge. Graphene solution-gated field-effect transistors (gSGFETs) show promise for broadband recordings, …
View article: Magnetoelectric Microrobots for Spinal Cord Injury Regeneration
Magnetoelectric Microrobots for Spinal Cord Injury Regeneration Open
Regenerative medicine continually seeks effective methods to address spinal cord injuries (SCI), which are known for their limited regenerative potential. Despite advances in neural progenitor cell (NPC) transplants for spinal cord injurie…
View article: Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions
Whole-brain model replicates sleep-like slow-wave dynamics generated by stroke lesions Open
Focal brain injuries, such as stroke, cause local structural damage as well as alteration of neuronal activity in distant brain regions. Experimental evidence suggests that one of these changes is the appearance of sleep-like slow waves in…
View article: Focus groups in the metaverse: shared virtual spaces for patients, clinicians, and researchers
Focus groups in the metaverse: shared virtual spaces for patients, clinicians, and researchers Open
Patient focus groups can be invaluable for facilitating user-centered design of medical devices and new technologies, effectively capturing the richness and depth of patient experiences to help thoroughly assess feasibility, tolerance, and…
View article: VIRTUAL REALITY FOR MENTAL HEALTH AND IN THEREHABILITATION OF VIOLENT BEHAVIOURS
VIRTUAL REALITY FOR MENTAL HEALTH AND IN THEREHABILITATION OF VIOLENT BEHAVIOURS Open
Immersive virtual reality creates a digital world that induces the illusion of presence, encompassing both the sense of being within the depicted virtual environment (place illusion) and the belief in the plausibility of events occurring w…
View article: Editorial: Horizons in Systems Neuroscience 2022
Editorial: Horizons in Systems Neuroscience 2022 Open
EDITORIAL article Front. Syst. Neurosci., 09 May 2024 Volume 18 - 2024 | https://doi.org/10.3389/fnsys.2024.1415569
View article: H-current modulation of cortical Up and Down states
H-current modulation of cortical Up and Down states Open
Understanding the link between cellular processes and brain function remains a key challenge in neuroscience. One crucial aspect is the interplay between specific ion channels and network dynamics. This work reveals a role for h-current, a…
View article: The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing
The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing Open
In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances a…
View article: A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets
A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets Open
Neuroscience is moving towards a more integrative discipline, where understanding brain function requires consolidating the accumulated evidence seen across experiments, species, and measurement techniques. A remaining challenge on that pa…
View article: Contents list
Contents list Open
Permissions Request permissions Contents list Nanoscale, 2024, 16, 493 DOI: 10.1039/D4NR90006E This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications…
View article: Brain state identification and neuromodulation to promote recovery of consciousness
Brain state identification and neuromodulation to promote recovery of consciousness Open
Experimental and clinical studies of consciousness identify brain states (i.e. quasi-stable functional cerebral organization) in a non-systematic manner and largely independent of the research into brain state modulation. In this narrative…
View article: A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets
A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets Open
Neuroscience is moving toward a more integrative discipline where understanding brain function requires consolidating the accumulated evidence seen across experiments, species, and measurement techniques. A remaining challenge on that path…
View article: Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states
Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states Open
Graphene-based transistors (gSGFETs) enabled stable full-band brain recordings for 5+ months, allowing precise brain state identification and prediction, which is critical both in brain science and neurology.
View article: Recording physiological and pathological cortical activity and exogenous electric fields using graphene microtransistor arrays <i>in vitro</i>
Recording physiological and pathological cortical activity and exogenous electric fields using graphene microtransistor arrays <i>in vitro</i> Open
Full-band recordings, including infraslow components, were obtained with graphene SGFETs from cerebral cortex slices. First gSGFETs recordings from human tissue in vitro were obtained. gSGFETs were also used to quantify both exogenous and …