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View article: Solid Ionic Matrices applied via Low-Temperature Evaporation enable High-Resolution and Sensitive MALDI Imaging of Metabolites
Solid Ionic Matrices applied via Low-Temperature Evaporation enable High-Resolution and Sensitive MALDI Imaging of Metabolites Open
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) has become a key technology for spatially resolved molecular analysis. However, imaging of low molecular weight compounds remains challenging due to spectral…
View article: Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk: The [email protected] Study
Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk: The [email protected] Study Open
Baseline circulating concentrations of SCFAs are associated with high-fiber food consumption and independently predict the development of T2D over seven years of follow-up. However, they offer limited improvement in risk prediction compare…
View article: INCREASE OF IL10 AND INFA2 ARE ASSOCIATED TO CLINICAL ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS
INCREASE OF IL10 AND INFA2 ARE ASSOCIATED TO CLINICAL ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS Open
PV069 / #444 Poster Topic: AS08 - Cytokines and Cell Trafficking Background/Purpose Systemic lupus erythematous (SLE) is an autoimmune disease characterized by deregulation of cytokine production. Interferon (IFN) is a proinflammatory cyto…
View article: DRUG-INDUCED LUPUS: CLINICAL AND SEROLOGICAL FEATURES IN A TERTIARY HOSPITAL
DRUG-INDUCED LUPUS: CLINICAL AND SEROLOGICAL FEATURES IN A TERTIARY HOSPITAL Open
PV218 / #452 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Several drugs have been implicated in the development of de novo systemic lupus erythematosus (SLE), unmasking of quiescent SLE or causing an ex…
View article: Cellular reprogramming by Acly inhibition using SB-204990 modulates molecular mechanisms with aging
Cellular reprogramming by Acly inhibition using SB-204990 modulates molecular mechanisms with aging Open
This directory contais MS-based data used for Metabolomics data analysis in either mzXML or mzML open standard formats. Conversion from vendor binary files was done through Proteowizard MS-Convert. The directory structure is as follows: F…
View article: Cellular reprogramming by Acly inhibition using SB-204990 modulates molecular mechanisms with aging
Cellular reprogramming by Acly inhibition using SB-204990 modulates molecular mechanisms with aging Open
iTRAQ labeling with two 8-plex iTRAQ kits was performed in the Proteomic facility of the Institute of Biomedicine of Seville using their standard protocols. Individual liver samples were isolated in urea lysis buffer (8 M urea, 25 mM Tris,…
View article: ChemEmbed: A deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings
ChemEmbed: A deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings Open
Machine learning tools have become essential for annotating the vast number of unidentified MS/MS spectra in metabolomics, addressing the limitations of current reference spectral libraries. However, these tools often struggle with the hig…
View article: Early-life chemical exposome: Comprehensive strategies for wide-scope screening of organic compounds
Early-life chemical exposome: Comprehensive strategies for wide-scope screening of organic compounds Open
Exposure to organic compounds during early-life stages can disrupt human development and increase susceptibility to adverse health outcomes later in life. Despite evidence of these impacts, research has primarily focused on targeted analys…
View article: Toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in early development: A wide-scope metabolomics assay in zebrafish embryos
Toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in early development: A wide-scope metabolomics assay in zebrafish embryos Open
The tobacco-specific nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a carcinogenic and ubiquitous environmental pollutant for which toxic activity has been thoroughly investigated in murine models and human tissues. Ho…
View article: Urinary metabolic dysregulations associated to thirdhand smoke exposure in mice: Implications for human urine biomonitoring
Urinary metabolic dysregulations associated to thirdhand smoke exposure in mice: Implications for human urine biomonitoring Open
This dataset contains all raw LC-MS and GC-MS data of urine extracts from mice exposed to thirdhand smoke (THS) used in the paper Urinary metabolic dysregulations associated to thirdhand smoke exposure in mice: Implications for human urine…
View article: Urinary metabolic dysregulations associated to thirdhand smoke exposure in mice: Implications for human urine biomonitoring
Urinary metabolic dysregulations associated to thirdhand smoke exposure in mice: Implications for human urine biomonitoring Open
This dataset contains all raw LC-MS and GC-MS data of urine extracts from mice exposed to thirdhand smoke (THS) used in the paper Urinary metabolic dysregulations associated to thirdhand smoke exposure in mice: Implications for human urine…
View article: Thirdhand smoke induces metabolic alterations associated with mitochondria dysfunction in kidney of exposed mice
Thirdhand smoke induces metabolic alterations associated with mitochondria dysfunction in kidney of exposed mice Open
This dataset contains all raw LC-MS data of kidney extracts from mice exposed to thirdhand smoke (THS) used in the paper Thirdhand smoke induces metabolic alterations associated with mitochondria dysfunction in kidney of exposed mice. Obje…
View article: Thirdhand smoke induces metabolic alterations associated with mitochondria dysfunction in kidney of exposed mice
Thirdhand smoke induces metabolic alterations associated with mitochondria dysfunction in kidney of exposed mice Open
This dataset contains all raw LC-MS data of kidney extracts from mice exposed to thirdhand smoke (THS) used in the paper Thirdhand smoke induces metabolic alterations associated with mitochondria dysfunction in kidney of exposed mice. Obje…
View article: S81 | THSTPS | Thirdhand Smoke Specific Metabolites
S81 | THSTPS | Thirdhand Smoke Specific Metabolites Open
A list of thirdhand smoke (THS) specific metabolites (TPs) contributed by Carla Merino, Noelia Ramirez and colleagues, URV, Spain. Dataset DOI: 10.5281/zenodo.5394629. v0.1.1: fixed formatting issues in CSV files (spacing around CIDs, name…
View article: S81 | THSTPS | Thirdhand Smoke Specific Metabolites
S81 | THSTPS | Thirdhand Smoke Specific Metabolites Open
This is the collection associated with list S81 THSTPS Thirdhand Smoke Specific Metabolites on the NORMAN Suspect List Exchange. https://www.norman-network.com/nds/SLE/ Data compiled by Carla Merino and colleagues, URV, Spain.
View article: S81 | THSTPS | Thirdhand Smoke Specific Metabolites
S81 | THSTPS | Thirdhand Smoke Specific Metabolites Open
A list of thirdhand smoke (THS) specific metabolites (TPs) contributed by Carla Merino, Noelia Ramirez and colleagues, URV, Spain. Dataset DOI: 10.5281/zenodo.5394629. v0.1.1: fixed formatting issues in CSV files (spacing around CIDs, name…
View article: Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice
Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice Open
Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2−/−) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. …
View article: HERMES: a molecular formula-oriented method to target the metabolome - Dataset
HERMES: a molecular formula-oriented method to target the metabolome - Dataset Open
This dataset contains all raw LC-MS1 and LC-MS2 data from river surface water, Escherichia coli, and human plasma used in the paper HERMES: a molecular formula-oriented method to target the metabolome, as well as the RMarkdown vignettes g…
View article: HERMES: a molecular formula-oriented method to target the metabolome - Dataset
HERMES: a molecular formula-oriented method to target the metabolome - Dataset Open
This dataset contains all raw LC-MS1 and LC-MS2 data from river surface water, Escherichia coli, and human plasma used in the paper HERMES: a molecular formula-oriented method to target the metabolome, as well as the RMarkdown vignettes g…
View article: Toxicity of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK) in early development: a wide-scope metabolomics assay in zebrafish embryos
Toxicity of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK) in early development: a wide-scope metabolomics assay in zebrafish embryos Open
The tobacco-specific nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a carcinogenic and ubiquitous environmental pollutant which carcinogenic and cytotoxic activity has been thoroughly investigated in murine models and …
View article: Toxicity of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in early development: a wide-scope metabolomics assay in zebrafish embryos
Toxicity of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in early development: a wide-scope metabolomics assay in zebrafish embryos Open
This dataset contains all raw LC-MS data and LC-MS/MS data from zebrafish embryos exposed to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) used in the paper Toxicity of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK) in early d…