Maria Yampolskaya
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View article: Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions
Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions Open
Multicellular organisms develop a wide variety of highly-specialized cell types. The consistency and robustness of developmental cell fate trajectories suggests that complex gene regulatory networks effectively act as low-dimensional cell …
View article: Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions
Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions Open
Multicellular organisms develop a wide variety of highly-specialized cell types. The consistency and robustness of developmental cell fate trajectories suggests that complex gene regulatory networks effectively act as low-dimensional cell …
View article: Generation of human alveolar epithelial type I cells from pluripotent stem cells
Generation of human alveolar epithelial type I cells from pluripotent stem cells Open
Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and have been historically challenging to isolate or maintain in cell culture. Here, we engineer a human in vitro AT1 model system via directed differ…
View article: scTOP: physics-inspired order parameters for cellular identification and visualization
scTOP: physics-inspired order parameters for cellular identification and visualization Open
Advances in single-cell RNA sequencing provide an unprecedented window into cellular identity. The abundance of data requires new theoretical and computational frameworks to analyze the dynamics of differentiation and integrate knowledge f…
View article: Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice Open
View article: scTOP: physics-inspired order parameters for cellular identification and visualization
scTOP: physics-inspired order parameters for cellular identification and visualization Open
Advances in single-cell RNA-sequencing (scRNA-seq) provide an unprecedented window into cellular identity. The increasing abundance of data requires new theoretical and computational frameworks for understanding cell fate determination, ac…
View article: Correction to: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Correction to: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis Open
View article: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis Open
View article: Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice Open
Durable reconstitution of the injured distal lung epithelium with pluripotent stem cell (PSC) derivatives, if realized, would represent a promising potential therapy for diseases that result from alveolar damage. Here we differentiate muri…
View article: Order-of-magnitude beam current improvement in compact cyclotrons
Order-of-magnitude beam current improvement in compact cyclotrons Open
There is great need for high intensity proton beams from compact particle accelerators in particle physics, medical isotope production, and materials- and energy-research. To address this need, we present, for the first time, a design for …
View article: The Isostatic Conjecture
The Isostatic Conjecture Open