Explanipedia

Two is Better Than One: Potentiating Cognitive Remediation With Aerobic Exercise to Improve Cognition in Schizophrenia With a Randomized Controlled Trial Open

Giulia Agostoni, Federica Repaci, Margherita Bechi, Irene Calzavara Pinton, Mariachiara Buonocore , et al. · 2025

Background: Cognitive impairment is a core feature of schizophrenia, for which pharmacological interventions have limited efficacy. Cognitive remediation (CR) is the gold standard for addressing cognitive deficits, yet its effect remains i…

Disentangling the contribution of inflammatory markers and kynurenines to cognitive impairment in schizophrenia Open

Jacopo Sapienza, Giulia Agostoni, S. El Sagher, Michele Francesco D'Incalci, M. Spangaro , et al. · 2025

Introduction Neuroinflammation and the Kynurenine Pathway (KP) have gained attention in the last decades in the pathogenesis of cognitive impairment in schizophrenia. Pro-inflammatory cytokines and microglia activation induce oxidative str…

From semantic concreteness to concretism in schizophrenia: An automated linguistic analysis of speech produced in figurative language interpretation Open

Valentina Bambini, Federico Frau, Luca Bischetti, Giulia Agostoni, Cristian Mevio , et al. · 2025

Lack of abstract thinking, known as concretism, is a well-known psychopathological feature of schizophrenia, reflecting the tendency to adhere to concrete aspects of stimuli and figurative language comprehension difficulties. Inspir…

Neuroinflammation and kynurenines in schizophrenia: Impact on cognition depending on cognitive functioning and modulatory properties in relation to cognitive remediation and aerobic exercise Open

Jacopo Sapienza, Giulia Agostoni, Stefano Comai, Sofia Nasini, Stefano Dall’Acqua , et al. · 2024

Overall, these findings add novel evidence on the biological underpinnings of cognitive impairment in schizophrenia pointing at a differential role of neuroinflammation and KP metabolites in inducing cognitive deficits depending on the cog…

From semantic concreteness to concretism in schizophrenia: An automated linguistic analysis of speech produced in figurative language interpretation Open

Valentina Bambini, Federico Frau, Luca Bischetti, Giulia Agostoni, Cristian Mevio , et al. · 2024

Lack of abstract thinking, known as concretism, is a well-known psychopathological feature of schizophrenia, reflecting the tendency to adhere to concrete aspects of stimuli and figurative language comprehension difficulties. Inspired by t…

Neuroinflammation and Kynurenines in schizophrenia: impact on cognition and modulatory properties after cognitive remediation and aerobic exercise Open

Jacopo Sapienza, Giulia Agostoni, Stefano Comai, Sofia Nasini, Stefano Dall’Acqua , et al. · 2024

Cognitive remediation combined with aerobic exercise to further improve cognition in schizophrenia Open

Marco Spangaro, Giulia Agostoni, Jacopo Sapienza, Federica Repaci, Margherita Bechi , et al. · 2024

Sleep quality in schizophrenia: association with psychopathology, cognition and metabolic syndrome Open

Michele Francesco D'Incalci, Carolina Passani, Jacopo Sapienza, Stefano Novello, A. Fortunato , et al. · 2024

Associated neurophysiological and neuropsychological patterns toward personalized rehabilitation in schizophrenia Open

Giulia Agostoni, Sara Zago, Margherita Bechi, Mariachiara Buonocore, Marco Spangaro , et al. · 2023

The cascade effect of autistic symptoms on pragmatics in schizophrenia: the role of executive functions and theory of mind Open

Jacopo Sapienza, Giulia Agostoni, Federica Cuoco, Margherita Bechi, Mariachiara Buonocore , et al. · 2023

Lifetime substance abuse and adverse childhood experiences in psychosis: impact on clinical outcomes Open

Francesca Martini, Marta Bosia, S. Marco, Mariachiara Buonocore, Margherita Bechi , et al. · 2023

Deconstructing heterogeneity in schizophrenia through language: a semi-automated linguistic analysis and data-driven clustering approach Open

Valentina Bambini, Federico Frau, Luca Bischetti, Federica Cuoco, Margherita Bechi , et al. · 2022

Obsessive-compulsive symptoms moderates the effects of cognitive functioning on quality of life in clozapine-treated schizophrenia Open

Giulia Agostoni, Margherita Bechi, Mariachiara Buonocore, Federica Cuoco, Jacopo Sapienza , et al. · 2022

Obsessive-compulsive symptoms (OCS) are frequently reported in clozapine-treated schizophrenia. Studies on the effects of OCS on cognitive abilities and quality of life (QoL) yielded contrasting results, ranging from benefits to adverse ef…

Cognitive remediation in schizophrenia: What happens after 10 years? Open

Mariachiara Buonocore, Marco Spangaro, Margherita Bechi, Stefania Trezzani, Rachele Terragni , et al. · 2022

Get up! Functional mobility and metabolic syndrome in chronic schizophrenia: Effects on cognition and quality of life Open

Federica Cuoco, Giulia Agostoni, Silvia Lesmo, Jacopo Sapienza, Mariachiara Buonocore , et al. · 2022

Low mobility and poor physical health, especially metabolic syndrome, are frequently reported in patients with schizophrenia and tend to increase with age. Recent evidence suggests that metabolic syndrome may affect cognition and quality o…

Exploring the interplay between kynurenine pathway, cognition, metabolic syndrome and treatment resistance in schizophrenia Open

Giulia Agostoni, Federica Cuoco, A. Marchesi, Margherita Bechi, Mariachiara Buonocore , et al. · 2022

Cognitive impairment in schizophrenia – disentangling the role of metabolic syndrome and inflammation Open

Marco Spangaro, Jacopo Sapienza, Francesca Martini, Giulia Agostoni, Margherita Bechi , et al. · 2022

Factors affecting cognitive remediation outcome in schizophrenia: The role of treatment resistance Open

Marco Spangaro, Marta Bosia, Francesca Martini, Margherita Bechi, Mariachiara Buonocore , et al. · 2021

Introduction Treatment-resistant schizophrenia (TRS) represents a major clinical issue, characterized by worse psychopathological outcome, a more disrupted neurobiological substrate and higher healthcare costs. Cognitive impairment is a co…

S67. TREATMENT-RESISTANCE AFFECTS LONG-TERM COGNITIVE TRAJECTORIES IN SCHIZOPHRENIA: A LONGITUDINAL STUDY Open

Marco Spangaro, Marta Bosia, Margherita Bechi, Mariachiara Buonocore, Francesca Martini , et al. · 2020

Background Schizophrenia is a highly heterogeneous disorder, and despite extensive research progress approximately 30% of patients with schizophrenia show poor response to first-line antipsychotics, denoted as treatment-resistant schizophr…

M51. EFFICACY OF “PRAGMACOM TRAINING” IN SCHIZOPHRENIA: A RCT ON A NOVEL PRAGMATIC INTERVENTION Open

Giulia Agostoni, Elisabetta Tonini, Mariachiara Buonocore, Margherita Bechi, Maria Paola Silvestri , et al. · 2020

Background A pragmatic disruption is observed in several clinical conditions and especially in schizophrenia. It is estimated that over 75% of patients affected by schizophrenia present a pervasive and wide impairment of pragmatic abilitie…

M202. SEX-RELATED DIFFERENCES IN CLOZAPINE SIDE EFFECTS IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA Open

Francesca Martini, Marta Bosia, Mariachiara Buonocore, Marco Spangaro, Margherita Bechi , et al. · 2020

Background Treatment resistant schizophrenia (TRS) affects up to 30% of patients with psychosis and is a major cause of disability. Although clozapine is the only indicated drug for TRS, it is largely underused, partially due to its life-t…

The association of autistic traits with Theory of Mind and its training efficacy in patients with schizophrenia Open

Margherita Bechi, Giulia Agostoni, Mariachiara Buonocore, Davide Gritti, Mattia Mascia , et al. · 2019

Literature has recently identified a discrete subgroup of patients affected by schizophrenia that also present autistic traits (ATs), showing a peculiar cognitive, clinical and functional profile. Theory of Mind (ToM) represents a core, im…

Improving Cognition to Increase Treatment Efficacy in Schizophrenia: Effects of Metabolic Syndrome on Cognitive Remediation's Outcome Open

Marta Bosia, Mariachiara Buonocore, Margherita Bechi, Laura Santarelli, Marco Spangaro , et al. · 2018

Cognitive impairment, typically more severe in treatment resistant patients, is considered a hallmark of schizophrenia and the prime driver of functional disability. Recent evidence suggests that metabolic syndrome may contribute to cognit…

Cognitive Reserve Profiles in Chronic Schizophrenia: Effects on Theory of Mind Performance and Improvement after Training Open

Mariachiara Buonocore, Margherita Bechi, Paola Uberti, Marco Spangaro, Federica Cocchi , et al. · 2018

Objectives: Cognitive reserve (CR), defined as individual differences in the ability to cope with brain damage, seem to be associated to the several psychopathological features in psychiatric patients, such as the functional outcome. This …

Achieving recovery in patients with schizophrenia through psychosocial interventions: <span>A</span> retrospective study Open

Mariachiara Buonocore, Marta Bosia, Maria Alice Baraldi, Margherita Bechi, Marco Spangaro , et al. · 2017

Aim Recovery, or functional remission, represents the ultimate treatment goal in schizophrenia. Despite its importance, a standardized definition of remission is still lacking, thus reported rates significantly vary across studies. Moreove…

Impact of Different e-Cigarette Generation and Models on Cognitive Performances, Craving and Gesture: A Randomized Cross-Over Trial (CogEcig) Open

Pasquale Caponnetto, Marilena Maglia, Maria Concetta Cannella, Lucio Inguscio, Mariachiara Buonocore , et al. · 2017

www.ClinicalTrials.gov, identifier NCT01735487.

Targeting the communicative impairment in schizophrenia with a neuropragmatic approach Open

Marta Bosia, Giorgio Arcara, Margherita Bechi, Mariachiara Buonocore, Roberto Cavallaro , et al. · 2017

Event Abstract Back to Event Targeting the communicative impairment in schizophrenia with a neuropragmatic approach Marta Bosia1, 2*, Giorgio Arcara3, Margherita Bechi2, Mariachiara Buonocore2, Roberto Cavallaro1, 2 and Valentina Bambini4 …

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