Mariam Adeleke
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Treatment patterns, care delays and outcomes in advanced cervical cancer: study protocol for a mixed retrospective and prospective single-centre cohort in South Africa Open
Introduction Cervical cancer (CaCx) is a leading cause of cancer-related deaths among women in South Africa, often presenting at advanced stages and requiring chemoradiotherapy. In South Africa, the burden is disproportionately high among …
View article: Process evaluation of APPLE-Tree (active prevention in people at risk of dementia through lifestyle behaviour change and technology to build resilience): dementia prevention study focused on health and lifestyle changes
Process evaluation of APPLE-Tree (active prevention in people at risk of dementia through lifestyle behaviour change and technology to build resilience): dementia prevention study focused on health and lifestyle changes Open
Background This concurrent, exploratory, mixed-methods process evaluation, embedded within a randomised controlled trial, investigates how the ‘active prevention in people at risk of dementia through lifestyle behaviour change and technolo…
Evaluating the Impact of Telehealth Exercise Prehabilitation on Cardiometabolic Health in Bariatric Surgery Candidates: Protocol for the BARI-Prehab Randomized Controlled Trial Open
Background Obesity affects over one billion people globally and is a leading contributor to chronic disease. For those with clinically severe obesity, metabolic and bariatric surgery (MBS) is the most effective intervention for long-term w…
View article: Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial
Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial Open
Economic and Social Research Council and National Institute for Health and Care Research programme grant.
Implementing Remote Radiotherapy Planning to Increase Patient Flow at a Johannesburg Academic Hospital, South Africa: Protocol for a Prospective Feasibility Study Open
Background Access to timely radiotherapy in resource-constrained environments, particularly low- and middle-income countries (LMIC), is hampered by infrastructure constraints, workforce shortages, and a rising cancer burden. Remote radioth…
View article: Process Evaluation of APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle bEhaviour Change and Technology to build REsiliEnce), a Dementia-Prevention Study focused on Health and Lifestyle changes
Process Evaluation of APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle bEhaviour Change and Technology to build REsiliEnce), a Dementia-Prevention Study focused on Health and Lifestyle changes Open
Introduction In a mixed-methods process evaluation embedded within a randomised controlled trial, we aimed to investigate how the APPLE-Tree secondary dementia prevention intervention might support behavioural and lifestyle goal attainment…
View article: Process evaluation in a randomised controlled trial of DREAMS-START (dementia related manual for sleep; strategies for relatives) for sleep disturbance in people with dementia and their carers
Process evaluation in a randomised controlled trial of DREAMS-START (dementia related manual for sleep; strategies for relatives) for sleep disturbance in people with dementia and their carers Open
Introduction DREAMS-START is a multicomponent intervention targeting sleep disturbance in people with dementia. To enhance understanding of the DREAMS-START randomised controlled trial, which showed improved sleep in the intervention compa…
View article: Selective Laser Trabeculoplasty After Medical Treatment for Glaucoma or Ocular Hypertension
Selective Laser Trabeculoplasty After Medical Treatment for Glaucoma or Ocular Hypertension Open
Importance Primary selective laser trabeculoplasty (SLT) is a safe primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT). However, there is limited evidence on its use as a secondary treatment, ie, after prior use o…
View article: Feasibility and Acceptability of Intervention and Trial Procedures of the UCL Live Well With Parkinson’s Self‐Management Toolkit
Feasibility and Acceptability of Intervention and Trial Procedures of the UCL Live Well With Parkinson’s Self‐Management Toolkit Open
Managing Parkinson’s disease (PD) symptoms can be challenging due to multiple factors, including complex symptoms, which are often reported late, and a lack of resources, resulting in worse outcomes. Self‐management of PD symptoms is a pri…
Clinical‐effectiveness of DREAMS START an intervention for with people with dementia and sleep disturbance and their caregivers ‐ A single masked, phase 3, parallel arms superiority randomised controlled trial Open
Background Sleep disturbance is common and distressing for people with dementia, with no known safe, effective treatments. We previously developed and delivered DREAMS‐START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives), a …
Clinical and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) for people living with dementia and their carers: a study protocol for a parallel multicentre randomised controlled trial Open
Introduction Many people living with dementia experience sleep disturbance and there are no known effective treatments. Non-pharmacological treatment options should be the first-line sleep management. For family carers, relatives’ sleep di…
View article: APPLE‐Tree remote secondary dementia prevention; opportunities for scalable public health interventions to reduce dementia risk
APPLE‐Tree remote secondary dementia prevention; opportunities for scalable public health interventions to reduce dementia risk Open
Background Nearly half of people aged 60+ experience memory impairments that infer an increased risk of dementia. The UK APPLE‐Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to buil…
View article: Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial
Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial Open
Selective laser trabeculoplasty is a safe treatment for OAG and OHT, providing better long-term disease control than initial drop therapy, with reduced need for incisional glaucoma and cataract surgery over 6 years.
Efficacy of Repeat Selective Laser Trabeculoplasty in Medication-Naive Open-Angle Glaucoma and Ocular Hypertension during the LiGHT Trial Open
These exploratory analyses demonstrate that repeat SLT can maintain IOP at or below target IOP in medication-naive OAG and OHT eyes requiring retreatment with at least an equivalent duration of effect to initial laser.