Mariam Andersson
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View article: Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: Axonal structure-function relationships across experimental modalities
Axonal structure-function relationships across experimental modalities Open
The structure-function relationship of myelinated nerve fibers (Waxman & Bennett, 1972) links axon diameter and myelin thickness, commonly expressed as the g-ratio, to conduction velocity via saltatory mechanisms. Here, we investigated thi…
View article: Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: Exploring white matter dynamics and morphology through interactive numerical phantoms: the White Matter Generator
Exploring white matter dynamics and morphology through interactive numerical phantoms: the White Matter Generator Open
Brain white matter is a dynamic environment that continuously adapts and reorganizes in response to stimuli and pathological changes. Glial cells, especially, play a key role in tissue repair, inflammation modulation, and neural recovery. …
View article: Reviewer #2 (Public Review): Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Reviewer #2 (Public Review): Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: Reviewer #1 (Public Review): Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Reviewer #1 (Public Review): Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: White matter multi-scale dataset: Diffusion weighted MRI and synchrotron x-ray scans of vervet monkey-, healthy mouse-, and cuprizone mouse brains
White matter multi-scale dataset: Diffusion weighted MRI and synchrotron x-ray scans of vervet monkey-, healthy mouse-, and cuprizone mouse brains Open
Overall description: This repository contains the essential processed data files featured in this bioRxiv article. All the article figures are derived from these files. Additional files, e.g. intermediate processing steps, original reconst…
View article: White matter multi-scale dataset: Diffusion weighted MRI and synchrotron x-ray scans of vervet monkey-, healthy mouse-, and cuprizone mouse brains
White matter multi-scale dataset: Diffusion weighted MRI and synchrotron x-ray scans of vervet monkey-, healthy mouse-, and cuprizone mouse brains Open
Overall description: This repository contains the essential processed data files featured in this bioRxiv article. All the article figures are derived from these files. Additional files, e.g. intermediate processing steps, original reconst…
View article: Exploring white matter dynamics and morphology through interactive numerical phantoms: The White Matter Generator
Exploring white matter dynamics and morphology through interactive numerical phantoms: The White Matter Generator Open
Brain white matter is a dynamic environment that continuously adapts and reorganizes in response to stimuli and pathological changes. Glial cells, especially, play a key role in tissue repair, inflammation modulation, and neural recovery. …
View article: Mapping axon diameters and conduction velocity in the rat brain – different methods tell different stories of the structure-function relationship
Mapping axon diameters and conduction velocity in the rat brain – different methods tell different stories of the structure-function relationship Open
The structure-function relationship of nerve fibers describes an empirically determined linear relationship between axon diameter, myelin thickness (i.e., g-ratio), and conduction velocity. We investigated the structure-function relationsh…
View article: Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species
Bridging the 3D geometrical organisation of white matter pathways across anatomical length scales and species Open
We used diffusion MRI and x-ray synchrotron imaging on monkey and mice brains to examine the organisation of fibre pathways in white matter across anatomical scales. We compared the structure in the corpus callosum and crossing fibre regio…
View article: Susceptibility-induced internal gradients reveal axon morphology and cause anisotropic effects in the dMRI signal
Susceptibility-induced internal gradients reveal axon morphology and cause anisotropic effects in the dMRI signal Open
Diffusion-weighted MRI is our most promising method for estimating microscopic tissue morphology in vivo. The signal acquisition is based on scanner-generated ex ternal magnetic gradients. However, it will also be affected by susceptibilit…
View article: Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI
Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI Open
We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates …
View article: Axial and radial axonal diffusivities from single encoding strongly diffusion-weighted MRI
Axial and radial axonal diffusivities from single encoding strongly diffusion-weighted MRI Open
We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates …
View article: Axonal <i>T</i><sub>2</sub> estimation using the spherical variance of the strongly diffusion-weighted MRI signal
Axonal <i>T</i><sub>2</sub> estimation using the spherical variance of the strongly diffusion-weighted MRI signal Open
In magnetic resonance imaging, the application of a strong diffusion weighting suppresses the signal contributions from the less diffusion-restricted constituents of the brain’s white matter, thus enabling the estimation of the transverse …
View article: Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures?
Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures? Open
Noninvasive estimation of axon diameter with diffusion MRI holds potential to investigate the dynamic properties of the brain network and pathology of neurodegenerative diseases. Recent methods use powder averaging to account for complex w…
View article: Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship
Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship Open
Significance Axons, the brain’s communication cables, have been described as cylinders since their discovery in 1860. Their structure is linked to how fast they conduct signals and is thus indicative of brain health and function. Here, we …
View article: 3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method?
3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method? Open
Phase-contrast X-ray tomography can be applied for volume analyses of the human ENS and to study tissue components in unstained paraffin-embedded tissue biopsies. This technique could potentially be used to study disease mechanisms, and to…
View article: Axon morphology is modulated by the local environment and impacts the non-invasive investigation of its structure-function relationship
Axon morphology is modulated by the local environment and impacts the non-invasive investigation of its structure-function relationship Open
Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Non-invasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires…
View article: 3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method?
3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method? Open
Light microscopical analysis in two dimensions, combined with immunohistochemistry, is presently the gold standard to describe the enteric nervous system (ENS). Our aim was to assess the usefulness of three-dimensional (3D) imaging by X-ra…
View article: Short-Wave infrared atmospheric scheimpflug lidar
Short-Wave infrared atmospheric scheimpflug lidar Open
Atmospheric dual-band Scheimpflug lidar is demonstrated at 980 and 1550 nm. Signals are compared during three weather conditions, and the spatio-temporal resolution of the atmospheric structure is considered. The potential for aerosol clas…
View article: Short-Wave Infrared Lidar on Atmospheric Aerosols and Insects
Short-Wave Infrared Lidar on Atmospheric Aerosols and Insects Open
This thesis focusses on the implementation of two elastic lidar (light detection and ranging) techniques for the monitoring of atmospheric aerosols and insects at short-wave infrared wavelengths. Data acquisition software was developed for…
View article: Feasibility of Implementing the PILATUS CdTe 300k Detector as a Real Time Gamma Camera in Intraoperative Medical Imaging
Feasibility of Implementing the PILATUS CdTe 300k Detector as a Real Time Gamma Camera in Intraoperative Medical Imaging Open
The full-width-at-half-maximum of the point spread functions for a pixellated cadmium telluride detector exposed to gammas from a 140.5 keV Tc-99m source are modelled in GATE, at a detector-collimator distance of 5 cm, and collimator-sourc…