Mohammad Khalid
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View article: CO2 capture and light driven photocatalytic conversion into useful compounds using neodymium doped bimetallic metal organic frameworks
CO2 capture and light driven photocatalytic conversion into useful compounds using neodymium doped bimetallic metal organic frameworks Open
Carbon dioxide (CO2) is one of the greenhouse gases and its concentration in an ambient environment is considerably increased in recent day. Potential management of CO2 by mitigation and sustainable conversion with utilization is urgent. A…
View article: <i>In silico</i> molecular docking analysis of potential antilipidemic bioactive constituents of <i>Coriandrum sativum</i> root extract using GC-MS
<i>In silico</i> molecular docking analysis of potential antilipidemic bioactive constituents of <i>Coriandrum sativum</i> root extract using GC-MS Open
The family Umbelliferae has many phytochemicals, predominantly in the roots of many species. While various studies have been conducted on phytochemical constituents and pharmacological activities of Coriandrum sativum leaves, very few expl…
View article: Ecotoxicity assessment and detection of antimicrobial compounds in urban environments and AMR hotspots
Ecotoxicity assessment and detection of antimicrobial compounds in urban environments and AMR hotspots Open
Environmental pollution by antimicrobial compounds poses a serious threat to aquatic ecosystems and human health due to their persistence and ability to promote antimicrobial resistance (AMR). This study evaluated the presence of five wide…
View article: Impacts of pharmaceutical and personal care products contamination as emerging contaminants in urban ecosystem: emerging risks and future challenges
Impacts of pharmaceutical and personal care products contamination as emerging contaminants in urban ecosystem: emerging risks and future challenges Open
The rising contamination of pharmaceuticals and personal care products (PPCPs) in urban water bodies is causing severe environmental and public health concerns, especially due to the rise of antimicrobial resistance (AMR). The study highli…
View article: Comparison of Fish and Soybean Meals on Growth Rate and Feed Efficiency of Fish Nile Tilapia (Oreochromis niloticus) Through the Use of Biofloc Technology
Comparison of Fish and Soybean Meals on Growth Rate and Feed Efficiency of Fish Nile Tilapia (Oreochromis niloticus) Through the Use of Biofloc Technology Open
Using biofloc technology, this study compared the effects of fish and soybean meals on the development rate and feed efficiency of fish Nile tilapia (Oreochromis niloticus) at the Fisheries Research and Training Institute (FR&TI) Manawan, …
View article: <b>Investigating the Association of Blackboard Teaching with Scapular Dyskinesia and Shoulder Pain Among School Teachers in Karachi, Pakistan</b>
<b>Investigating the Association of Blackboard Teaching with Scapular Dyskinesia and Shoulder Pain Among School Teachers in Karachi, Pakistan</b> Open
Background: Musculoskeletal disorders (MSDs) represent a significant occupational health burden globally, with teachers frequently reporting shoulder pain due to repetitive overhead tasks such as blackboard writing. Scapular dyskinesia, ch…
View article: Advances in smart hybrid scaffolds: A strategic approach for regenerative clinical applications
Advances in smart hybrid scaffolds: A strategic approach for regenerative clinical applications Open
The emergence of innovative 3D-printed hybrid scaffolds is transforming the landscape of tissue engineering by effectively addressing various regenerative clinical challenges. These scaffolds, which combine the advantageous properties of m…
View article: Transferrin-modified Gemcitabine Encapsulated Polymeric Nanoparticles Persuaded Apoptosis in U87MG Cells and Improved Drug Availability in Rat Brain: An Active Targeting Strategy for Treatment of Glioma
Transferrin-modified Gemcitabine Encapsulated Polymeric Nanoparticles Persuaded Apoptosis in U87MG Cells and Improved Drug Availability in Rat Brain: An Active Targeting Strategy for Treatment of Glioma Open
Among primary brain tumors, glioma has one of the highest fatality rates. Routine chemotherapy often faces off-target drug loss and sub-optimal drug availability at brain tissue. The present study aims at the development of transferrin-con…
View article: Luliconazole–niacinamide lipid nanocarrier laden gel for enhanced treatment of vaginal candidiasis: <i>in vitro</i>, <i>ex vivo</i>, <i>in silico</i> and preclinical insights
Luliconazole–niacinamide lipid nanocarrier laden gel for enhanced treatment of vaginal candidiasis: <i>in vitro</i>, <i>ex vivo</i>, <i>in silico</i> and preclinical insights Open
A lipid-based nanocarrier system is a novel technique for the delivery of poorly soluble drugs through topical delivery.
View article: A review: Innovative technologies in cancer care
A review: Innovative technologies in cancer care Open
Technological advancements are revolutionizing cancer care, improving diagnostics, treatment delivery, and patient outcomes. This review discusses innovations such as artificial intelligence (AI), precision medicine, advanced imaging, robo…
View article: Role of Chromatography in Pharmaceutical Analysis: Trends and Future Perspectives
Role of Chromatography in Pharmaceutical Analysis: Trends and Future Perspectives Open
Chromatography is a widely used analytical technique for separating and analyzing compounds present in complex mixtures. It operates on the principle of differential distribution of components between a stationary phase and a mobile phase,…
View article: Development of Gentamicin Bilosomes Laden <i>In Situ</i> Gel for Topical Ocular Delivery: Optimization, <i>In Vitro</i> Characterization, Toxicity, and Anti-microbial Evaluation
Development of Gentamicin Bilosomes Laden <i>In Situ</i> Gel for Topical Ocular Delivery: Optimization, <i>In Vitro</i> Characterization, Toxicity, and Anti-microbial Evaluation Open
Purpose: The eye drops are the prominent preparation used to treat surface eye disease (bacterial conjunctivitis). However, they have some limitations i.e., short corneal residence, resulting in low ocular bioavailability and necessitating…
View article: Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach
Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach Open
Interleukin-8 (IL-8) is a chemokine, a type of signaling molecule that has a role in immunological responses and inflammation. In recent years, IL-8 is additionally related to cancer growth and recurrence. Breast cancer growth, progression…
View article: Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches
Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches Open
Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a n…
View article: Pharmacogenetics and Pharmacogenomics Impact on Aspirin Response
Pharmacogenetics and Pharmacogenomics Impact on Aspirin Response Open
Aspirin, or Acetylsalicylic acid (ASA), is renowned for its pain-relieving and anti-inflammatory properties. Recent insights have illuminated its mechanisms and potential applications. Notably, low-dose aspirin reduces heart attack and str…
View article: Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study
Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study Open
At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with the initiation and subsequent progression of prostate carcinomas. The present report elucidated the anti-cancerous attribute…
View article: Corrigendum: Stylopine: a potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy
Corrigendum: Stylopine: a potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy Open
[This corrects the article DOI: 10.3389/fphar.2023.1150270.].
View article: An updated comprehensive review of the therapeutic properties of Chamomile ( <i>Matricaria chamomilla</i> L.)
An updated comprehensive review of the therapeutic properties of Chamomile ( <i>Matricaria chamomilla</i> L.) Open
Neurological and cardiovascular illnesses, cancers, metabolic disorders, and microbial infections result in deaths of millions of people globally. Recent researches have intensely been directed at evaluating the therapeutic potential of he…
View article: Niosomes gel of apigenin to improve the topical delivery: development, optimization, <i>ex vivo</i> permeation, antioxidant study, and <i>in vivo</i> evaluation
Niosomes gel of apigenin to improve the topical delivery: development, optimization, <i>ex vivo</i> permeation, antioxidant study, and <i>in vivo</i> evaluation Open
Niosomes (NS) are the promising and novel carrier of the drug for effective transdermal delivery. Apigenin (AN) is a natural bioactive compound and has various pharmacological activities. AN is poorly water soluble which directly affects t…
View article: Pegylated bilosomes for improvement of oral delivery of Biochanin A: Development to preclinical evaluation
Pegylated bilosomes for improvement of oral delivery of Biochanin A: Development to preclinical evaluation Open
Biochanin A (BC) is a natural herbal isoflavone compound and potentially benefits human health. It had poor solubility which led to poor bioavailability. The present work was to develop pegylated bilosomes (BSpeg) to enhance the therapeuti…
View article: Cardioprotective potential of Lavandula stoechas against isoprenaline-induced myocardial necrosis in rats
Cardioprotective potential of Lavandula stoechas against isoprenaline-induced myocardial necrosis in rats Open
This study assessed Lavandula stoechas flower extract's impact on Isoprenaline-induced myocardial necrosis in rats. Five groups of five rats each were used. Group I received 1 ml/kg normal saline orally for 13 days, Group II received 10 …
View article: Development of Soft Luliconazole Invasomes Gel for Effective Transdermal Delivery: Optimization to In-Vivo Antifungal Activity
Development of Soft Luliconazole Invasomes Gel for Effective Transdermal Delivery: Optimization to In-Vivo Antifungal Activity Open
Luliconazole (LZ) is a good candidate for the treatment of fungal infection topically but has limitations, i.e., poor solubility and poor permeability to skin. Due to these limitations, multiple administrations for a long time are required…
View article: Hypophyllanthin and Phyllanthin from <i>Phyllanthus niruri</i> Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells
Hypophyllanthin and Phyllanthin from <i>Phyllanthus niruri</i> Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells Open
Doxorubicin (DOX) is a cornerstone chemotherapeutic agent for the treatment of several malignancies such as breast cancer; however, its activity is ameliorated by the development of a resistant phenotype. Phyllanthus species have been stud…
View article: Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation
Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation Open
The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by the melt emulsification …
View article: Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches
Bioassay-guided identification of potential Alzheimer’s disease therapeutic agents from Kaempferol-Enriched fraction of Aframomum melegueta seeds using in vitro and chemoinformatics approaches Open
Alzheimer's disease (AD) has become a major public health concern and the fifth major cause of death among the aging population globally. In this study, the total phenols and flavonoids contents (TPC and TFC) and in vitro antioxidant actio…
View article: Mental Health and Coping Strategies among University Staff during the COVID-19 Pandemic: A Cross–Sectional Analysis from Saudi Arabia
Mental Health and Coping Strategies among University Staff during the COVID-19 Pandemic: A Cross–Sectional Analysis from Saudi Arabia Open
This study examined psychological health and coping strategies among faculty and staff at a Saudi Arabian university. A web-based self-administered survey was used to assess probable anxiety, depression, post-traumatic stress disorder (PTS…
View article: Trastuzumab-Mediated Cardiotoxicity and Its Preventive Intervention by Zingerone through Antioxidant and Inflammatory Pathway in Rats
Trastuzumab-Mediated Cardiotoxicity and Its Preventive Intervention by Zingerone through Antioxidant and Inflammatory Pathway in Rats Open
Trastuzumab (TZB) is a new medicine, used to treat cancers of the breast and stomach. However, the cardiotoxic potential of this drug edges out its clinical advantages. The present study was designed to find out the effect of zingerone aga…