Marian Showell
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View article: P-782 Obstetric and Neonatal Outcomes following Freeze-all vs Fresh Embryo Transfer Strategies: An Individual Participant Data Meta-Analysis of Randomised Trials (INFORM)
P-782 Obstetric and Neonatal Outcomes following Freeze-all vs Fresh Embryo Transfer Strategies: An Individual Participant Data Meta-Analysis of Randomised Trials (INFORM) Open
Study question Do obstetric and neonatal outcomes following the first transfer differ between a freeze-all and a fresh embryo transfer strategy? Summary answer Compared to fresh embryo transfer, freeze-all strategy increases large for gest…
View article: Triggering oocyte maturation in in vitro fertilization treatment in healthy responders: a systematic review and network meta-analysis
Triggering oocyte maturation in in vitro fertilization treatment in healthy responders: a systematic review and network meta-analysis Open
The findings indicate that there is no evidence to suggest that using GnRH agonist, dual, or double protocols is superior to hCG trigger in improving CPR. Although LBR may benefit from dual trigger, results are limited by available RCTs. L…
View article: #311 : Intrauterine Administration of Human Chorionic Gonadotropin in Women Undergoing IVF– An Individual Participant Data Meta-Analysis
#311 : Intrauterine Administration of Human Chorionic Gonadotropin in Women Undergoing IVF– An Individual Participant Data Meta-Analysis Open
Background and Aims: Human chorionic gonadotropin (hCG) has been proposed as an intrauterine intervention around embryo transfer period due to its potential to enhance endometrium receptivity and implantation. Existing randomised controlle…
View article: Obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer and the role of luteal phase support: a systematic review and meta-analysis
Obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer and the role of luteal phase support: a systematic review and meta-analysis Open
BACKGROUND The number of frozen embryo transfers (FET) has increased dramatically over the past decade. Based on current evidence, there is no difference in pregnancy rates when natural cycle FET (NC-FET) is compared to artificial cycle FE…
View article: Is our public research money well spent? Publication of research outputs from Health Research Council of New Zealand-funded studies: a cross-sectional study
Is our public research money well spent? Publication of research outputs from Health Research Council of New Zealand-funded studies: a cross-sectional study Open
Objective To evaluate the reporting of results from the projects and programmes funded by the Health Research Council (HRC) New Zealand. Design A cross-sectional analysis. Setting Research projects and programmes funded by the HRC New Zeal…
View article: Publication bias in trials registered in the Australian New Zealand Clinical Trials Registry: Is it a problem? A cross-sectional study
Publication bias in trials registered in the Australian New Zealand Clinical Trials Registry: Is it a problem? A cross-sectional study Open
Background Timely publication of clinical trials is critical to ensure the dissemination and implementation of high-quality healthcare evidence. This study investigates the publication rate and time to publication of randomized controlled …
View article: <i>In</i> dividual participant data meta-analysis of trials comparing <i>f</i> r <i>o</i> zen versus f <i>r</i> esh e <i>m</i> bryo transfer strategy (INFORM): a protocol
<i>In</i> dividual participant data meta-analysis of trials comparing <i>f</i> r <i>o</i> zen versus f <i>r</i> esh e <i>m</i> bryo transfer strategy (INFORM): a protocol Open
Introduction Existing randomised controlled trials (RCTs) comparing a freeze-all embryo transfer strategy and a fresh embryo transfer strategy have shown conflicting results. A freeze-all or a fresh transfer policy may be preferable for so…
View article: P-784 Less obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer
P-784 Less obstetric and neonatal outcomes after natural versus artificial cycle frozen embryo transfer Open
Study question Do obstetric and neonatal outcomes of women who conceived through natural cycle frozen embryo transfer (NC-FET) differ compared to an artificial cycle (AC-FET) method? Summary answer Fewer obstetric and neonatal complication…
View article: P-790 Mode of conception and pregnancy outcomes: systematic review and meta-analysis of 110 studies and 33,655,021 singleton pregnancies
P-790 Mode of conception and pregnancy outcomes: systematic review and meta-analysis of 110 studies and 33,655,021 singleton pregnancies Open
Study question Does mode of conception such as in-vitro fertilisation (IVF), ovulation induction (OI), intra-uterine insemination (IUI) affect singleton pregnancy outcomes when compared to spontaneous conception (SC)? Summary answer Single…
View article: The effect of hyaluronic acid in embryo transfer media in donor oocyte cycles and autologous oocyte cycles: a systematic review and meta-analysis
The effect of hyaluronic acid in embryo transfer media in donor oocyte cycles and autologous oocyte cycles: a systematic review and meta-analysis Open
STUDY QUESTION Does the addition of hyaluronic acid (HA) to embryo transfer medium improve pregnancy outcomes in both autologous and oocyte donation IVF cycles? SUMMARY ANSWER The best available evidence indicates that the addition of HA t…
View article: Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis
Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis Open
BACKGROUND Intrauterine insemination with ovarian stimulation (IUI-OS) is a first-line treatment for unexplained infertility. Gonadotrophins, letrozole and clomiphene citrate (CC) are commonly used agents during IUI-OS and have been compar…
View article: Are we leaving money on the table in infertility RCTs? Trialists should statistically adjust for prespecified, prognostic covariates to increase power
Are we leaving money on the table in infertility RCTs? Trialists should statistically adjust for prespecified, prognostic covariates to increase power Open
Infertility randomized controlled trials (RCTs) are often too small to detect realistic treatment effects. Large observational studies have been proposed as a solution. However, this strategy threatens to weaken the evidence base further, …
View article: Pharmacological interventions for jet lag
Pharmacological interventions for jet lag Open
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. This review aims to evaluate both the beneficial and adverse effects of pharmacological interventions for jet lag in people who undertake …
View article: Identifying the gaps, reducing the waste, and setting priorities in Cochrane gynaecology research
Identifying the gaps, reducing the waste, and setting priorities in Cochrane gynaecology research Open
Objective The aim of this project was to identify gaps and research waste in the dissemination of Cochrane gynaecology evidence in the Cochrane database of systematic reviews (CDSR). Design A research article Setting The Cochrane Gynaecolo…
View article: Identifying the gaps, reducing the waste and setting priorities in Cochrane fertility research: Research article
Identifying the gaps, reducing the waste and setting priorities in Cochrane fertility research: Research article Open
Objective The aim of this project was to identify gaps and research waste in the dissemination of fertility evidence in the Cochrane database of systematic reviews (CDSR). Design A research article. Setting The Cochrane Gynaecology and Fer…
View article: Top 10 priorities for future infertility research: an international consensus development study
Top 10 priorities for future infertility research: an international consensus development study Open
Study Question: Can the priorities for future research in infertility be identified?Summary Answer: The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction,…
View article: Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study
Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study Open
View article: Developing a core outcome set for future infertility research: an international consensus development study
Developing a core outcome set for future infertility research: an international consensus development study Open
View article: Developing a core outcome set for future infertility research: an international consensus development study
Developing a core outcome set for future infertility research: an international consensus development study Open
STUDY QUESTION Can a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed? SUMMARY ANSWER A minimum data set, known as a core outcome set, has been developed for random…
View article: Top 10 priorities for future infertility research: an international consensus development study
Top 10 priorities for future infertility research: an international consensus development study Open
STUDY QUESTION Can the priorities for future research in infertility be identified? SUMMARY ANSWER The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction a…
View article: Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study
Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study Open
STUDY QUESTION Can consensus definitions for the core outcome set for infertility be identified in order to recommend a standardized approach to reporting? SUMMARY ANSWER Consensus definitions for individual core outcomes, contextual state…
View article: Antioxidants for female subfertility
Antioxidants for female subfertility Open
BACKGROUND:A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of …
View article: Authors’ reply re: Evaluation of treatments for Bartholin’s cyst or abscess: A systematic review. (Response to BJOG-20-1118)
Authors’ reply re: Evaluation of treatments for Bartholin’s cyst or abscess: A systematic review. (Response to BJOG-20-1118) Open
Sir, We would like to thank Sharma and colleagues for their interest in our recent study evaluating the effectiveness and safety of surgical interventions for Bartholin’s cyst or abscess.1Their response highlights the unique opportunity of…
View article: Should empiric therapies be used for male factor infertility?
Should empiric therapies be used for male factor infertility? Open
View article: Research priority setting in women’s health: a systematic review
Research priority setting in women’s health: a systematic review Open
Background Developing a shared agenda is an important step in ensuring future research has the necessary relevance. Objective To characterise research priority setting partnerships (PSPs) relevant to women’s health. Search strategy Include…
View article: Top ten priorities for future infertility research
Top ten priorities for future infertility research Open
Introduction: Despite the escalation in research activity and an exponential rise in published papers, many of the fundamental questions about the treatment of infertility remain. This is a barrier to improving the care people with inferti…
View article: Antioxidants for male subfertility: A systematic review and meta-analysis
Antioxidants for male subfertility: A systematic review and meta-analysis Open
This review shows that antioxidant supplementation in subfertile men may improve live birth rates for couples, however the quality of the available evidence is low.
View article: Antioxidants for male subfertility
Antioxidants for male subfertility Open
BACKGROUND:The inability to have children affects 10% to 15% of couples worldwide. A male factor is estimated to account for up to half of the infertility cases with between 25% to 87% of male subfertility considered to be due to the effec…
View article: Inositol for subfertile women with polycystic ovary syndrome
Inositol for subfertile women with polycystic ovary syndrome Open
In light of available evidence of very low quality, we are uncertain whether MI improves live birth rate or clinical pregnancy rate in subfertile women with PCOS undergoing IVF pre-treatment taking MI compared to standard treatment. We are…
View article: 45 Developing, evaluating, and implementing patient delivered intimate examination training across nine north-east london hospitals
45 Developing, evaluating, and implementing patient delivered intimate examination training across nine north-east london hospitals Open
Context Pelvic examination is an essential component of the care women receive. Medical students are required to acquire these pelvic examination skills as a core competency. However, learning to perform the pelvic examination is difficult…