Mariana Kleinecke
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View article: Rapid detection of G6PD deficiency SNPs using a novel amplicon-based MinION Sequencing Assay
Rapid detection of G6PD deficiency SNPs using a novel amplicon-based MinION Sequencing Assay Open
Plasmodium vivax malaria remains a significant global health challenge, complicated by the parasite’s ability to form dormant liver stages (hypnozoites) that cause relapses. Radical cure of P. vivax malaria requires administration of a hyp…
View article: Microhaplotype deep sequencing assays to capture<i>Plasmodium vivax</i>infection lineages
Microhaplotype deep sequencing assays to capture<i>Plasmodium vivax</i>infection lineages Open
The elimination of Plasmodium vivax is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses that enhance transmission. Relapsing infections confound antimalarial clinical…
View article: Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages
Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages Open
The elimination of Plasmodium vivax is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses that enhance transmission. Relapsing infections confound antimalarial clinical…
View article: P. vivax microhaplotype deep sequencing assays v1
P. vivax microhaplotype deep sequencing assays v1 Open
This SOP is adapted from a high throughput rhAmpSeq library preparation protocol by integrated DNA technologies (IDT) and has been optimized at the Australian Genomic Research Facility. The SOP describes the laboratory procedures for ampli…
View article: Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction
Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction Open
View article: Complete genome sequence of <i>Oligella urethralis</i> MSHR-50412PR, isolated from an ear discharge swab of a child with chronic suppurative otitis media
Complete genome sequence of <i>Oligella urethralis</i> MSHR-50412PR, isolated from an ear discharge swab of a child with chronic suppurative otitis media Open
Oligella urethralis are opportunistic pathogens typically associated with genitourinary infections. Here, we report the complete genome for an Oligella urethralis isolate recovered from ear discharge of a child with chronic s…
View article: Lineage-informative microhaplotypes for spatio-temporal surveillance of<i>Plasmodium vivax</i>malaria parasites
Lineage-informative microhaplotypes for spatio-temporal surveillance of<i>Plasmodium vivax</i>malaria parasites Open
Challenges in understanding the origin of recurrent Plasmodium vivax infections constrains the surveillance of antimalarial efficacy and transmission of this neglected parasite. Recurrent infections within an individual may arise from acti…
View article: Can non‐typeable <i>Haemophilus influenzae</i> carriage surveillance data infer antimicrobial resistance associated with otitis media?
Can non‐typeable <i>Haemophilus influenzae</i> carriage surveillance data infer antimicrobial resistance associated with otitis media? Open
Importance In remote communities of the Northern Territory, Australia, children experience high rates of otitis media (OM), commonly caused by non‐typeable Haemophilus influenzae (NTHi). Few data exist on antibiotic susceptibility of NTHi …
View article: Melioidosis in the remote Katherine region of northern Australia
Melioidosis in the remote Katherine region of northern Australia Open
Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events a…
View article: Emergence of <i>Burkholderia pseudomallei</i> Sequence Type 562, Northern Australia
Emergence of <i>Burkholderia pseudomallei</i> Sequence Type 562, Northern Australia Open
Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek…
View article: Whole-genome sequencing of Burkholderia pseudomallei from an urban melioidosis hot spot reveals a fine-scale population structure and localised spatial clustering in the environment
Whole-genome sequencing of Burkholderia pseudomallei from an urban melioidosis hot spot reveals a fine-scale population structure and localised spatial clustering in the environment Open
Melioidosis is a severe disease caused by the environmental bacterium Burkholderia pseudomallei that affects both humans and animals throughout northern Australia, Southeast Asia and increasingly globally. While there is a considerable deg…
View article: Melioidosis fatalities in captive slender-tailed meerkats (Suricata suricatta): combining epidemiology, pathology and whole-genome sequencing supports variable mechanisms of transmission with one health implications
Melioidosis fatalities in captive slender-tailed meerkats (Suricata suricatta): combining epidemiology, pathology and whole-genome sequencing supports variable mechanisms of transmission with one health implications Open
Background Melioidosis is a tropical infectious disease which is being increasingly recognised throughout the globe. Infection occurs in humans and animals, typically through direct exposure to soil or water containing the environmental ba…
View article: A cluster of melioidosis infections in hatchling saltwater crocodiles (Crocodylus porosus) resolved using genome-wide comparison of a common north Australian strain of Burkholderia pseudomallei
A cluster of melioidosis infections in hatchling saltwater crocodiles (Crocodylus porosus) resolved using genome-wide comparison of a common north Australian strain of Burkholderia pseudomallei Open
Burkholderia pseudomallei is a Gram-negative saprophytic bacillus and the aetiological agent of melioidosis, a disease of public-health importance throughout Southeast Asia and northern Australia. Infection can occur in humans and a wide a…
View article: A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors Open
View article: A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors Open
Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of c…
View article: Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction
Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction Open