Mariana Leguía
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View article: Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines
Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines Open
View article: Systems Biology-Based Assessment of Immune Responses to Whole Cell and Acellular Pertussis Vaccines: Rationale, Methodology and Enrollment Procedures for Omics Workflows
Systems Biology-Based Assessment of Immune Responses to Whole Cell and Acellular Pertussis Vaccines: Rationale, Methodology and Enrollment Procedures for Omics Workflows Open
Given the local and systemic adverse reactions associated with whole cell pertussis vaccines combined with diphtheria and tetanus toxoids (DTP), acellular pertussis vaccines combined with the same toxoids (DTaP) were developed in the 1990s…
View article: A new lineage nomenclature to aid genomic surveillance of dengue virus
A new lineage nomenclature to aid genomic surveillance of dengue virus Open
Dengue virus (DENV) is currently causing epidemics of unprecedented scope in endemic settings and expanding to new geographical areas. It is therefore critical to track this virus using genomic surveillance. However, the complex patterns o…
View article: Arbovirus researchers unite: expanding genomic surveillance for an urgent global need
Arbovirus researchers unite: expanding genomic surveillance for an urgent global need Open
View article: Comparison of Four Methods of RNA Extraction and cDNA Synthesis from The Venom of Peruvian Snakes of the Genus Bothrops of Clinical Importance
Comparison of Four Methods of RNA Extraction and cDNA Synthesis from The Venom of Peruvian Snakes of the Genus Bothrops of Clinical Importance Open
RNA purification and cDNA synthesis represents the starting point for molecular analyses of snake venom proteins-enzymes. Usually, the sacrifice of snakes is necessary for venom gland extraction to identify protein-coding transcripts; howe…
View article: Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru
Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru Open
Highly pathogenic avian influenza (HPAI) A/H5N1 viruses (lineage 2.3.4.4b) are rapidly invading the Americas, threatening wildlife, poultry, and potentially evolving into the next global pandemic. In November 2022, HPAI arrived in Peru, wh…
View article: Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis of <i>Rickettsia asembonensis</i> in Peru
Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis of <i>Rickettsia asembonensis</i> in Peru Open
Despite several reports worldwide documenting the presence of Rickettsia asembonensis in samples derived from ectoparasites, animals and more recently humans, genomic information of these specimens remains scarce, and when available…
View article: Peru – Progress in health and sciences in 200 years of independence
Peru – Progress in health and sciences in 200 years of independence Open
El Perú cumple 200 años de independencia en 2021. Durante estos dos siglos de vida independiente, junto con periodos sociales y políticos turbulentos, incluyendo un conflicto armado interno, hiperinflación y la inestabilidad política de lo…
View article: Efficacy of a Spatial Repellent for Control of <i>Aedes</i>-Borne Virus Transmission: A Cluster Randomized Trial in Iquitos, Peru
Efficacy of a Spatial Repellent for Control of <i>Aedes</i>-Borne Virus Transmission: A Cluster Randomized Trial in Iquitos, Peru Open
Over half the world’s population is at risk for viruses transmitted by Aedes mosquitoes, such as, dengue and Zika. The primary vector, Aedes aegypti , thrives in urban environments. Despite decades of effort, cases and geographic range of …
View article: Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing
Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing Open
This brief report serves as an introduction to a supplement of the Journal of Infectious Diseases entitled “Next-Generation Sequencing (NGS) Technologies to Advance Global Infectious Disease Research.” We briefly discuss the history of NGS…
View article: Seroprevalence and Risk Factors for Rickettsia and Leptospira Infection in Four Ecologically Distinct Regions of Peru
Seroprevalence and Risk Factors for Rickettsia and Leptospira Infection in Four Ecologically Distinct Regions of Peru Open
Rickettsia and Leptospira spp. are under-recognized causes of acute febrile disease worldwide. Rickettsia species are often placed into the spotted fever group rickettsiae (SFGR) and typhus group rickettsiae (TGR). We explored the antibody…
View article: Reflexiones acerca del espacio
Reflexiones acerca del espacio Open
En estas reflexiones, se nos muestra a la arquitectura de hoy presentada por una serie de contradicciones entre posiciones confrontadas, ya que la especialización en algunos campos ha impuesto su protagonismo sobre la profesión, buscando c…
View article: Isolation of Complete Equine Encephalitis Virus Genome from Human Swab Specimen, Peru
Isolation of Complete Equine Encephalitis Virus Genome from Human Swab Specimen, Peru Open
While studying respiratory infections in Peru, we identified Venezuelan equine encephalitis virus (VEEV) in a nasopharyngeal swab, indicating that this alphavirus can be present in human respiratory secretions. Because VEEV may be infectio…
View article: <i>Rickettsia asembonensis</i> Characterization by Multilocus Sequence Typing of Complete Genes, Peru
<i>Rickettsia asembonensis</i> Characterization by Multilocus Sequence Typing of Complete Genes, Peru Open
While studying rickettsial infections in Peru, we detected Rickettsia asembonensis in fleas from domestic animals. We characterized 5 complete genomic regions (17kDa, gltA, ompA, ompB, and sca4) and conducted multilocus sequence typing and…
View article: Serologic Evidence of Scrub Typhus in the Peruvian Amazon
Serologic Evidence of Scrub Typhus in the Peruvian Amazon Open
Using a large, passive, febrile surveillance program in Iquitos, Peru, we retrospectively tested human blood specimens for scrub typhus group orientiae by ELISA, immunofluorescence assay, and PCR. Of 1,124 participants, 60 (5.3%) were sero…
View article: Whole-Genome Analysis of<i>Bartonella</i><i>ancashensis</i>, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
Whole-Genome Analysis of<i>Bartonella</i><i>ancashensis</i>, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru Open
The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living …
View article: Rickettsial Disease in the Peruvian Amazon Basin
Rickettsial Disease in the Peruvian Amazon Basin Open
Using a large, passive, clinic-based surveillance program in Iquitos, Peru, we characterized the prevalence of rickettsial infections among undifferentiated febrile cases and obtained evidence of pathogen transmission in potential domestic…
View article: Targeted full-genome amplification and sequencing of dengue virus types 1–4 from South America
Targeted full-genome amplification and sequencing of dengue virus types 1–4 from South America Open
View article: Full Genomic Characterization of a Saffold Virus Isolated in Peru
Full Genomic Characterization of a Saffold Virus Isolated in Peru Open
While studying respiratory infections of unknown etiology we detected Saffold virus in an oropharyngeal swab collected from a two-year-old female suffering from diarrhea and respiratory illness. The full viral genome recovered by deep sequ…
View article: Feasibility and effectiveness of a brief, intensive phylogenetics workshop in a middle-income country
Feasibility and effectiveness of a brief, intensive phylogenetics workshop in a middle-income country Open
There is an increasing role for bioinformatic and phylogenetic analysis in tropical medicine research. However, scientists working in low- and middle-income regions may lack access to training opportunities in these methods. To help addres…
View article: Complete Genome Sequence of Bartonella ancashensis Strain 20.00, Isolated from the Blood of a Patient with Verruga Peruana
Complete Genome Sequence of Bartonella ancashensis Strain 20.00, Isolated from the Blood of a Patient with Verruga Peruana Open
Here we present the complete genome sequence of Bartonella ancashensis strain 20.00, isolated from the blood of a Peruvian patient with verruga peruana, known as Carrion's disease. Bartonella ancashensis is a Gram-negative bacillus, phylog…