Mariana Oksdath
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View article: New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology
New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology Open
Glioblastoma is an aggressive form of primary brain cancer for which new treatment approaches are desperately needed. To achieve this goal, better experimental approaches to study human glioblastoma are required; and in particular, methods…
View article: Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids
Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids Open
Stem cell-derived brain organoids provide a powerful platform for systematic studies of tissue functional architecture and the development of personalized therapies. Here, we review key advances at the interface of soft matter and stem cel…
View article: The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system
The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system Open
The amyloid precursor protein ( APP ) is a type I transmembrane glycoprotein better known for its participation in the physiopathology of Alzheimer disease as the source of the beta amyloid fragment. However, the physiological functions of…
View article: Protein interacting with NIMA (never in mitosis A)‐1 regulates axonal growth cone adhesion and spreading through myristoylated alanine‐rich C kinase substrate isomerization
Protein interacting with NIMA (never in mitosis A)‐1 regulates axonal growth cone adhesion and spreading through myristoylated alanine‐rich C kinase substrate isomerization Open
Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine‐rich C kinase substrate ( MARCKS ) protein is enriched in the develop…