Mariana Widmer
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View article: Advancing maternal and perinatal health through clinical trials: key insights from a WHO global consultation
Advancing maternal and perinatal health through clinical trials: key insights from a WHO global consultation Open
Pregnant and lactating women have long been excluded from participation in clinical research. This exclusion has resulted in the absence of high-quality evidence on the effectiveness and safety of medical products (medicines, vaccines, and…
View article: Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus
Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus Open
OBJECTIVE: There are no globally agreed on strategies on early detection and first response management of postpartum haemorrhage (PPH) during and after caesarean birth. Our study aimed to develop an international expert's consensus on evid…
View article: Research agenda for ending preventable maternal deaths from postpartum haemorrhage: a WHO research prioritisation exercise
Research agenda for ending preventable maternal deaths from postpartum haemorrhage: a WHO research prioritisation exercise Open
Introduction Postpartum haemorrhage (PPH) remains the leading cause of maternal death. Yet there is a lack of clarity around what research is needed to determine what works and how best to deliver proven PPH interventions. This article des…
View article: Quality assessment of oxytocin injection and misoprostol tablets in Côte d’Ivoire and Senegal
Quality assessment of oxytocin injection and misoprostol tablets in Côte d’Ivoire and Senegal Open
Objective : To assess the quality of oxytocin and misoprostol products available in Côte d’Ivoire and Senegal. Methods : Samples of oxytocin injections and misoprostol tablets were collected from three different levels of the supply chain …
View article: Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus
Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus Open
Objective There are no globally agreed on strategies on early detection and first response management of postpartum haemorrhage (PPH) during and after caesarean birth. Our study aimed to develop an international expert’s consensus on evide…
View article: What do healthcare providers think of the quality of uterotonics? A mixed-methods systematic review
What do healthcare providers think of the quality of uterotonics? A mixed-methods systematic review Open
Objectives To synthesise evidence on the perceptions of healthcare providers (HCPs) about the quality of oxytocin and misoprostol available in their settings, and their actions as a result of these perceptions. Design Mixed-methods systema…
View article: Strategies for optimising early detection and first response management of postpartum haemorrhage at caesarean birth: A modified Delphi-based international expert consensus
Strategies for optimising early detection and first response management of postpartum haemorrhage at caesarean birth: A modified Delphi-based international expert consensus Open
OBJECTIVE There are no globally agreed upon strategies on early detection and first response management of postpartum haemorrhage during and after caesarean birth. Our study aimed to develop an international expert’s consensus on evidence-…
View article: Heat stable carbetocin or oxytocin for prevention of postpartum hemorrhage among women at risk: A secondary analysis of the <scp>CHAMPION</scp> trial
Heat stable carbetocin or oxytocin for prevention of postpartum hemorrhage among women at risk: A secondary analysis of the <span>CHAMPION</span> trial Open
Objective To examine whether the observed non‐inferiority of heat‐stable carbetocin (HSC), compared with oxytocin, was influenced by biologic (macrosomia, parity 3 or more, or history of postpartum hemorrhage [PPH]) and/or pharmacologic (i…
View article: Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage
Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage Open
Early detection of postpartum hemorrhage and use of bundled treatment led to a lower risk of the primary outcome, a composite of severe postpartum hemorrhage, laparotomy for bleeding, or death from bleeding, than usual care among patients …
View article: Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial
Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial Open
Background: Multi-arm multi-stage trials are an efficient, adaptive approach for testing many treatments simultaneously within one protocol. In settings where numbers of patients available to be entered into trials and resources might be l…
View article: Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies
Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies Open
National Institute for Health and Care Research, Wellbeing of Women.
View article: Tranexamic acid at cesarean delivery: Drug‐error deaths
Tranexamic acid at cesarean delivery: Drug‐error deaths Open
The use of tranexamic acid for postpartum hemorrhage has entered obstetrical practice globally with the evidence‐based expectation of saving lives. This improvement in the care of women with postpartum hemorrhage has come at a price. For t…
View article: Tranexamic acid at cesarean delivery: drug‐error deaths
Tranexamic acid at cesarean delivery: drug‐error deaths Open
The use of tranexamic acid for postpartum hemorrhage has entered obstetrical practice globally with the evidence‐based expectation of saving lives. This improvement in the care of women with postpartum hemorrhage has come at a price. For t…
View article: Tranexamic acid at cesarean delivery: drug-error deaths
Tranexamic acid at cesarean delivery: drug-error deaths Open
View article: Duration of third stage labour and postpartum blood loss: a secondary analysis of the WHO CHAMPION trial data
Duration of third stage labour and postpartum blood loss: a secondary analysis of the WHO CHAMPION trial data Open
View article: Route of oxytocin administration for preventing blood loss at caesarean section: a systematic review with meta-analysis
Route of oxytocin administration for preventing blood loss at caesarean section: a systematic review with meta-analysis Open
Objectives Assess the effects of different routes of prophylactic oxytocin administration for preventing blood loss at caesarean section (CS). Design Systematic review and meta-analysis. Methods Medline, EMBASE, CINAHL, Cochrane Library, B…
View article: Effectiveness of uterine tamponade devices for refractory postpartum haemorrhage after vaginal birth: a systematic review
Effectiveness of uterine tamponade devices for refractory postpartum haemorrhage after vaginal birth: a systematic review Open
Objectives To evaluate uterine tamponade devices’ effectiveness for atonic refractory postpartum haemorrhage (PPH) after vaginal birth and the effect of including them in institutional protocols. Search strategy PubMed, EMBASE, CINAHL, LIL…
View article: Timing of oxytocin administration to prevent post-partum hemorrhage in women delivered by cesarean section: A systematic review and metanalysis
Timing of oxytocin administration to prevent post-partum hemorrhage in women delivered by cesarean section: A systematic review and metanalysis Open
Background There is no consensus on the best timing for prophylactic oxytocin administration during cesarean section (CS) to prevent post-partum hemorrhage (PPH). Objectives Assess the effects of administrating prophylactic oxytocin at dif…
View article: Duration of Third Stage Labour and Postpartum Blood Loss: a Secondary Analysis of the WHO CHAMPION Trial Data
Duration of Third Stage Labour and Postpartum Blood Loss: a Secondary Analysis of the WHO CHAMPION Trial Data Open
Background: Obstetric haemorrhage continues to be a leading cause of maternal mortality, contributing to more than a quarter of the 2,443,000 maternal deaths reported between 2003 and 2009. During this period, about 70% of the haemorrhagic…
View article: Effect of Heat stable Carbetocin vs Oxytocin for Preventing Postpartum Haemorrhage on Post Delivery Hemoglobin- A Randomized Controlled Trial
Effect of Heat stable Carbetocin vs Oxytocin for Preventing Postpartum Haemorrhage on Post Delivery Hemoglobin- A Randomized Controlled Trial Open
BackgroundPost-partum haemorrhage is one of the major causes of maternal mortality in low- and middle-income countries. Oxytocin is the first choice uterotonic for the PPH prevention but it requires cold storage. Heat stable carbetocin app…
View article: Healthcare providers experiences of using uterine balloon tamponade (UBT) devices for the treatment of post-partum haemorrhage: A meta-synthesis of qualitative studies
Healthcare providers experiences of using uterine balloon tamponade (UBT) devices for the treatment of post-partum haemorrhage: A meta-synthesis of qualitative studies Open
Background Postpartum haemorrhage (PPH) is a leading cause of maternal mortality and severe morbidity globally. When PPH cannot be controlled using standard medical treatments, uterine balloon tamponade (UBT) may be used to arrest bleeding…
View article: Correction to: Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention
Correction to: Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention Open
View article: Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention
Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention Open
View article: Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight
Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight Open
[This corrects the article DOI: 10.1371/journal.pmed.1002220.].
View article: EFFECTIVENESS OF UTERINE TAMPONADE DEVICES FOR REFRACTORY POSTPARTUM HAEMORRHAGE AFTER VAGINAL BIRTH: A SYSTEMATIC REVIEW
EFFECTIVENESS OF UTERINE TAMPONADE DEVICES FOR REFRACTORY POSTPARTUM HAEMORRHAGE AFTER VAGINAL BIRTH: A SYSTEMATIC REVIEW Open
Objectives: to evaluate the effectiveness of uterine tamponade devices for atonic refractory postpartum haemorrhage (PPH) after vaginal birth, and the effect of including uterine tamponade devices in institutional protocols. Search strateg…
View article: Uterotonic agents for first-line treatment of postpartum haemorrhage: a network meta-analysis
Uterotonic agents for first-line treatment of postpartum haemorrhage: a network meta-analysis Open
The available evidence suggests that oxytocin used as first-line treatment of PPH probably is more effective than misoprostol with less side-effects. Adding misoprostol to the conventional treatment of oxytocin probably makes little or no …
View article: Cost‐effectiveness of uterine tamponade devices for the treatment of postpartum hemorrhage: A systematic review
Cost‐effectiveness of uterine tamponade devices for the treatment of postpartum hemorrhage: A systematic review Open
Background Uterine tamponade is widely promoted for treating refractory postpartum hemorrhage (PPH); however, its cost‐effectiveness may vary depending on unit costs and setting. Objective To review available data on cost‐effectiveness of …
View article: Prevalence of failed samples over time.
Prevalence of failed samples over time. Open
View article: PRISMA check list.
PRISMA check list. Open
View article: Quality scores of 34 studies over time.
Quality scores of 34 studies over time. Open