Marianna Nalli
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View article: Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei Open
View article: Emerging Direct Targeting β-Catenin Agents
Emerging Direct Targeting β-Catenin Agents Open
Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specifi…
View article: Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment Open
View article: RS6077 Induces Mitotic Arrest and Selectively Activates Cell Death in Human Cancer Cell Lines and in a Lymphoma Tumor In Vivo
RS6077 Induces Mitotic Arrest and Selectively Activates Cell Death in Human Cancer Cell Lines and in a Lymphoma Tumor In Vivo Open
View article: Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia Open
View article: CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme Open
View article: Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics Open
View article: Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists
Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists Open
Kynurenine (kyn) and kynurenic acid (kyna) are well-defined metabolites of tryptophan catabolism collectively known as “kynurenines”, which exert regulatory functions in host-microbiome signaling, immune cell response, and neuronal excitab…
View article: Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors
Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors Open
We report here the synthesis and human carbonic anhydrases (CA, EC 4.2.1.1) inhibitory properties of a series of 4'-substituted 1,1'-biphenyl-4-sulfonamides incorporating a 2″- or 3″-amino- or carboxyphenyl unit. Most compounds showed sign…
View article: CCDC 1043565: Experimental Crystal Structure Determination
CCDC 1043565: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …