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View article: Socioeconomic status modifies the association between adherence to the Mediterranean diet and cognitive outcomes: results from the Collaborative PROMED-COG Pooled Cohorts Study
Socioeconomic status modifies the association between adherence to the Mediterranean diet and cognitive outcomes: results from the Collaborative PROMED-COG Pooled Cohorts Study Open
Background This study examines whether adherence to the Mediterranean diet (MD), alone and combined with physical activity (MedEx), is associated with cognitive decline and dementia incidence, with socioeconomic status (SES) as a potential…
View article: Impact of a four-domain intrinsic capacity measure on falls: findings from the EPOSA study
Impact of a four-domain intrinsic capacity measure on falls: findings from the EPOSA study Open
Objective Low Intrinsic Capacity (IC) has been associated with adverse health outcomes in older adults, including falls. This study examines a four-domain measure of IC (cognition, psychological, locomotion, vitality) and its relationship …
View article: Feasibility and Potential Effects of Multidomain Interventions to Improve the Cognitive and Functional Well-Being of Elderly Individuals in Residential Structures: The I-COUNT Pilot Study Protocol
Feasibility and Potential Effects of Multidomain Interventions to Improve the Cognitive and Functional Well-Being of Elderly Individuals in Residential Structures: The I-COUNT Pilot Study Protocol Open
Background/Objectives: Multidisciplinary approaches spanning the physical, cognitive, and social domains of geriatric evaluation are essential to promote functional well-being and reduce the aversive consequences of aging. The main objecti…
View article: The Impact of Atrial Fibrillation on Physical Performance in Older Adults: A Longitudinal Study in Relation to Cognitive Function
The Impact of Atrial Fibrillation on Physical Performance in Older Adults: A Longitudinal Study in Relation to Cognitive Function Open
AF impacts physical performance, notably walking speed and handgrip strength, varying by cognitive decline and sex. Multidisciplinary interventions, including optimized AF management and geriatric care strategies, are crucial for preservin…
View article: An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training
An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training Open
The TTB intervention not only improved cognitive and physical outcomes but also modulated key immune markers associated with neuroinflammation and aging. IL-10, in particular, emerged as potential peripheral biomarker of training efficacy.…
View article: Body weight trajectories from midlife are associated with cognitive decline in advanced age
Body weight trajectories from midlife are associated with cognitive decline in advanced age Open
View article: Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study
Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study Open
View article: M3.3.1 - Cutting-edge healthcare technologies for monitoring, care and coaching in elderly residential facilities: the perspec-tive of the Italian project “Age-it”
M3.3.1 - Cutting-edge healthcare technologies for monitoring, care and coaching in elderly residential facilities: the perspec-tive of the Italian project “Age-it” Open
View article: Harmonizing Dietary Exposure of Adult and Older Individuals: A Methodological Work of the Collaborative PROMED-COG Pooled Cohorts Study
Harmonizing Dietary Exposure of Adult and Older Individuals: A Methodological Work of the Collaborative PROMED-COG Pooled Cohorts Study Open
Objectives: The PROtein-enriched MEDiterranean diet to combat undernutrition and promote healthy neuroCOGnitive ageing in older adults (PROMED-COG) is a European project that investigates the role of nutritional status on neurocognitive ag…
View article: Undernutrition, cognitive decline and dementia: The collaborative PROMED-COG pooled cohorts study
Undernutrition, cognitive decline and dementia: The collaborative PROMED-COG pooled cohorts study Open
Undernutrition is prevalent among older people and is associated with an increased risk of experiencing cognitive decline and dementia. The prevention and early identification of undernutrition could be an important nonpharmacologic strate…
View article: Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances
Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances Open
View article: Changes in Sleep Duration and Sleep Timing in the General Population from before to during the First COVID-19 Lockdown: A Systematic Review and Meta-Analysis
Changes in Sleep Duration and Sleep Timing in the General Population from before to during the First COVID-19 Lockdown: A Systematic Review and Meta-Analysis Open
Background: The COVID-19 lockdown had a profound effect on everyday life, including sleep health. This systematic review and meta-analysis evaluated changes in quantitative sleep parameters during the first lockdown compared with pre-lockd…
View article: A multidisciplinary approach to improve adherence to medical recommendations in older adults at hospital discharge: The APPROACH study protocol
A multidisciplinary approach to improve adherence to medical recommendations in older adults at hospital discharge: The APPROACH study protocol Open
Introduction Poor comprehension and medication adherence are common in older people, especially after hospitalizations, in case of changes or prescriptions of new therapeutic regimes. This randomized controlled trial aims to evaluate the e…
View article: New Perspectives in the Association between Anthropometry and Mortality: The Role of Calf Circumference
New Perspectives in the Association between Anthropometry and Mortality: The Role of Calf Circumference Open
CC has a validity comparable to MNA and ASMMI in predicting mortality at 3, 6 and 12 months after hospital discharge. Moreover, it can be considered an independent predictor of medium-term mortality in the hospitalized older population. CC…
View article: A Step-by-Step Harmonization Process for Nutritional Epidemiology Purposes: A Methodological Work of the Collaborative PROMED-COG Pooled Cohorts Study
A Step-by-Step Harmonization Process for Nutritional Epidemiology Purposes: A Methodological Work of the Collaborative PROMED-COG Pooled Cohorts Study Open
Background and objectives: Pooling datasets for nutritional epidemiological purposes are becoming more common because of their several advantages. Here, we described our step-by-step dietary data harmonization process applied within the PR…
View article: Effects of PROtein enriched MEDiterranean Diet and EXercise on nutritional status and cognition in adults at risk of undernutrition and cognitive decline: the PROMED-EX Randomised Controlled Trial.
Effects of PROtein enriched MEDiterranean Diet and EXercise on nutritional status and cognition in adults at risk of undernutrition and cognitive decline: the PROMED-EX Randomised Controlled Trial. Open
Introduction Undernutrition leading to unplanned weight loss is common in older age and has been linked to increased dementia risk in later life. Weight loss can precede dementia by a decade or more, providing a unique opportunity for earl…
View article: Poverty and Influenza/Pneumococcus Vaccinations in Older People: Data from The Survey of Health, Ageing and Retirement in Europe (SHARE) Study
Poverty and Influenza/Pneumococcus Vaccinations in Older People: Data from The Survey of Health, Ageing and Retirement in Europe (SHARE) Study Open
Vaccine acceptance seems to be lower in poor people. The determinants of the lower vaccine coverage in poor people are not established. Therefore, we aimed to explore the association between poverty and influenza/pneumococcus vaccinations …
View article: Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis
Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis Open
Background Breast cancer during pregnancy (PrBC) is a rare condition known for its aggressive clinical behavior. The presence of tumor-infiltrating lymphocytes (TILs) has been shown to have a significant impact on the prognosis of these pa…
View article: Ferric Carboxymaltose in Patients with Acute Decompensated Heart Failure and Iron Deficiency: A Real-Life Study
Ferric Carboxymaltose in Patients with Acute Decompensated Heart Failure and Iron Deficiency: A Real-Life Study Open
Background: The correction of iron deficiency (ID) with ferric carboxymaltose (FCM) is a recommended intervention in heart failure (HF) with reduced ejection fraction. Our aim is to evaluate, in a real-life setting, the clinical significan…
View article: Efficacy of COVID-19 control measures on post-vaccination outbreak in Italian Long Term Care Facilities: implications for policies
Efficacy of COVID-19 control measures on post-vaccination outbreak in Italian Long Term Care Facilities: implications for policies Open
Background Numerous individual and organizational factors can influence the spread of SARS-CoV-2 infection in Long Term Care Facilities (LTCFs). A range of outbreak control measures are still implemented in most facilities involving admini…
View article: Clinical profile of trazodone users in a multisetting older population: data from the Italian GeroCovid Observational study
Clinical profile of trazodone users in a multisetting older population: data from the Italian GeroCovid Observational study Open
View article: Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up
Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up Open
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild cognitive impairment (MCI). The ‘Train the Brain’ programme is a combined motor and cognitive…
View article: Sex differences in the efficacy and safety of SARS-CoV-2 vaccination in residents of long-term care facilities: insights from the GeroCovid Vax study
Sex differences in the efficacy and safety of SARS-CoV-2 vaccination in residents of long-term care facilities: insights from the GeroCovid Vax study Open
Despite the reported sex-related variations in the immune response to vaccination, whether the effects of SARS-CoV-2 vaccination differ by sex is still under debate, especially considering old vulnerable individuals, such as long-term care…
View article: Changes in sleep quality and sleep disturbances in the general population from before to during the COVID-19 lockdown: A systematic review and meta-analysis
Changes in sleep quality and sleep disturbances in the general population from before to during the COVID-19 lockdown: A systematic review and meta-analysis Open
Introduction This systematic review and meta-analysis aims to explore changes in sleep quality and sleep disturbances in the general population from before to during the COVID-19 lockdown. Methods The protocol was registered in PROSPERO (C…
View article: Hospital length of stay and 30-day readmissions in older people: their association in a 20-year cohort study in Italy
Hospital length of stay and 30-day readmissions in older people: their association in a 20-year cohort study in Italy Open
Background There are conflicting data on whether hospital length of stay (LOS) reduction affects readmission rates in older adults. We explored 20-year trends of hospital LOS and 30-day rehospitalizations in a cohort of Italian older peopl…
View article: Somatically evoked cough responses help to identify patients with difficult-to-treat chronic cough: a six-month observational cohort study
Somatically evoked cough responses help to identify patients with difficult-to-treat chronic cough: a six-month observational cohort study Open
This work was funded by an unrestricted grant from Merck (Italy).
View article: The role of nutrition and the Mediterranean diet on the trajectories of cognitive decline
The role of nutrition and the Mediterranean diet on the trajectories of cognitive decline Open
The worldwide burden of dementia is immense, and set to increase to unprecedented levels in the coming decades, due to population aging. In the absence of disease-modifying treatment, there is therefore a strong rationale to support the as…
View article: Inflammation and Prostate Cancer: Pathological Analysis from Pros-IT CNR 2
Inflammation and Prostate Cancer: Pathological Analysis from Pros-IT CNR 2 Open
Background: Extensive research effort has been devoted to investigating the link between inflammation and PCa. However, this relationship remains unclear and controversial. The aim of our multi-center study was to investigate this associat…
View article: The impact of falls on the need for hospital care in older people: results from the Pro.V.A. study
The impact of falls on the need for hospital care in older people: results from the Pro.V.A. study Open
Background and aims. Falls have been associated with adverse health-related outcomes in older people, but their effects on the need for hospital admissions is unclear. We investigated the association between falls and all-cause hospitaliza…
View article: Patient-Factors Influencing the 2-Year Trajectory of Mental and Physical Health in Prostate Cancer Patients
Patient-Factors Influencing the 2-Year Trajectory of Mental and Physical Health in Prostate Cancer Patients Open
This study aimed to examine the physical and mental Quality of Life (QoL) trajectories in prostate cancer (PCa) patients participating in the Pros-IT CNR study. QoL was assessed using the Physical (PCS) and Mental Component Score (MCS) of …