Explanipedia

Optical Coherence Tomography Angiography Is Associated with Disease Activity Expressed by NEDA-3 Status in Patients with Relapsing Multiple Sclerosis Open

Jozef Szilasi, Marianna Vitková, Zuzana Gdovinová, Miriam Fedičová, Pavol Mikula , et al. · 2025

Background: Retinal microvascular changes may serve as biomarkers for disease activity in multiple sclerosis (MS). This study evaluated macular and peripapillary vascular plexus densities using optical coherence tomography angiography (OCT…

Plasma NfL and GFAP as Candidate Biomarkers of Disease Activity in NMOSD and MOGAD Open

Jarmila Szilasiová, Miriam Fedičová, Marianna Vitková, Zuzana Gdovinová, Jozef Szilasi , et al. · 2025

Background and Objectives: Neuromyelitis optica spectrum disorder (NMOSD) and MOG antibody-associated disease (MOGAD) are distinct autoimmune demyelinating disorders of the central nervous system, characterized by different pathological an…

Suicidal ideation in people with multiple sclerosis and its association with coping self-efficacy Open

Pavol Mikula, Vladimíra Timková, Marianna Vitková, Jarmila Szilasiová, Iveta Nagyová · 2024

People with MS may significantly benefit from psychological support aimed at promoting coping self-efficacy and utilization of various coping strategies. Problem-focused coping, coping focused on getting support, and coping focused on stop…

Reader Response: <i>D313Y</i> Variant in Fabry Disease: A Systematic Review and Meta-analysis Open

Alexandra Lacková, Jarmila Szilasiová, Marianna Vitková, Miriam Ostrožovičová, Matěj Škorvánek · 2023

We read with great interest the meta-analysis of Palaiodimou et al.1 who evaluated prevalence and phenotypic characteristics of GLA D313Y variant carriers. Based on their results, the D313Y variant seems to correlate with an atypical, mild…

Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis Open

Miriam Fedičová, Pavol Mikula, Zuzana Gdovinová, Marianna Vitková, Norbert Žilka , et al. · 2023

Background and Objectives: Neurofilament light chain (NfL) is a sensitive biomarker of neuroaxonal damage. This study aimed to assess the relationship between the annual change in plasma NfL (pNfL) and disease activity in the past year, as…

Importance of Retesting for the Final Diagnosis of Post-Stroke Cognitive Impairment Open

Dominik Koreň, Miriam Slavkovská, Marianna Vitková, Zuzana Gdovinová · 2023

Background and Objectives: Post-stroke cognitive impairment (PSCI) has been defined as all problems in cognitive function that occur following a stroke. Studies published thus far on the prevalence of PSCI and post-stroke dementia (PSD) ha…

2327 Latitude, UVR and multiple sclerosis severity Open

Marianna Vitková, Ibrahima Diouf, Charles B. Malpas, Michael Barnett, Suzanne Hodgkinson , et al. · 2022

Objectives This study aimed to investigate the association between latitude of residence, ultraviolet B radiation exposure (UVB) and MS severity. Methods This observational study used MSBase registry data. Included patients met the 2005 or…

Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis Open

Marianna Vitková, Ibrahima Diouf, Charles B. Malpas, Dana Horáková, Eva Havrdová , et al. · 2022

In temperate zones, MS severity is associated with latitude. This association is mainly, but not exclusively, driven by UVB exposure contributing to both MS susceptibility and severity.

Did the severity of the COVID-19 outbreak affect the quality of acute stroke care? (Data from across the country) Open

Zuzana Gdovinová, Marianna Vitková, Anna Baráková, Alena Cvopová · 2022

Introduction: The aim of our study was to determine whether the severity of the COVID-19 pandemic affected the quality of acute care of stroke. Methods: Data from the stroke register at the National Health Information Centre were analysed.…

Associations between neurofilament light chain levels, disease activity and brain atrophy in progressive multiple sclerosis Open

Jarmila Szilasiová, Pavol Mikula, Jaroslav Rosenberger, Miriam Fedičová, Peter Urban , et al. · 2021

The results show that pNfL levels are a useful biomarker of disease activity determined by NEDA-3 status, including brain MRI-volumetry, in patients with the progressive form of MS.

The impact of the COVID‐19 outbreak on acute stroke care in Slovakia: Data from across the country Open

Zuzana Gdovinová, Marianna Vitková, Anna Baráková, Alena Cvopová · 2020

Background and purpose A few studies using data from regional databases have recently pointed to a decreased number of patients with stroke. The aim of the present study was to describe country‐level data (the number of patients with strok…

Multiple sclerosis (MS) is autoimmune disorder affecting the central nervous system Open

Miriam Fedičová, Marianna Vitková, Jarmila Szilasiová, Zuzana Gdovinová · 2020

Sclerosis multiplex (SM) je autoimunitné ochorenie centrálneho nervového systému.V súčasnosti máme k dispozícii pomerne širokú škálu ochorenie modifikujúcich liečiv (Disease Modifying Therapy -DMT) s rôznym mechanizmom účinku a účinnosťou.…

Fatigue and Suicidal Ideation in People With Multiple Sclerosis: The Role of Social Support Open

Pavol Mikula, Vladimíra Timková, Marcela Linková, Marianna Vitková, Jarmila Szilasiová , et al. · 2020

Fatigue and poor sleep quality are among the most common patient-reported problems associated with multiple sclerosis (MS). Social support, on the other hand, is often found to be positively associated with quality of life in patients with…

Multiple sclerosis and coping: is disease management easier with good self-esteem? Open

Pavol Mikula, Iveta Nagyová, Marianna Vitková, Jarmila Szilasiová · 2016

Background Multiple sclerosis (MS) is a disease with serious health and social consequences which requires effective disease management. Patients engage in various coping behaviours in order to manage their disease. The aim of this study…

Poor sleep quality and other symptoms affecting quality of life in patients with multiple sclerosis Open

Marianna Vitková · 2015

This study focuses on poor sleep quality and other neuropsychiatric manifestations of multiple sclerosis (MS). Emphasis is put on symptoms of MS, such as pain, depression, anxiety or fatigue, and how they are related to poor sleep quality …

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