Marianne F. James
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Additional Cover Open
Cover legend: The cover image is based on the article A longevity‐specific bank of induced pluripotent stem cells from centenarians and their offspring by George Murphy et al., https://doi.org/10.1111/acel.14351. [Image: see text]
View article: A longevity‐specific bank of induced pluripotent stem cells from centenarians and their offspring
A longevity‐specific bank of induced pluripotent stem cells from centenarians and their offspring Open
Centenarians provide a unique lens through which to study longevity, healthy aging, and resiliency. Moreover, models of human aging and resilience to disease that allow for the testing of potential interventions are virtually non‐existent.…
View article: A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring
A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring Open
Centenarians provide a unique lens through which to study longevity, healthy aging, and resiliency. Moreover, models of human aging and resilience to disease that allow for the testing of potential interventions are virtually non-existent.…
View article: Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations
Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations Open
Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease …
View article: Data from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
Data from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types Open
Inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene results in the development of schwannomas and meningiomas. Using NF2-deficient meningioma cells and tumors, together with the normal cellular counterparts…
View article: Data from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
Data from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types Open
Inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene results in the development of schwannomas and meningiomas. Using NF2-deficient meningioma cells and tumors, together with the normal cellular counterparts…
View article: Supplementary Figure 1 from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
Supplementary Figure 1 from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types Open
PDF file - 105K, Receptor phosphorylation in merlin-deficient Schwann cells in response to serum deprivation, IGF-1 and PDGF stimulation
View article: Supplementary Figure 1 from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
Supplementary Figure 1 from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types Open
PDF file - 105K, Receptor phosphorylation in merlin-deficient Schwann cells in response to serum deprivation, IGF-1 and PDGF stimulation
View article: A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells
A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells Open
View article: A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and <i>in vitro</i> testing of novel therapeutics
A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and <i>in vitro</i> testing of novel therapeutics Open
Hereditary transthyretin amyloidosis (ATTR amyloidosis) is an autosomal dominant protein-folding disorder caused by over 100 distinct mutations in the transthyretin (TTR) gene. In ATTR amyloidosis, protein secreted from the liver aggregate…
View article: A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus
A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus Open
We established a new patient-derived meningioma model that will enable the study of targeted therapeutic approaches for HGM. Based on these studies, it is reasonable to consider a clinical trial of G47Δ for HGM.
View article: Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency
Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency Open
The multi-subunit mammalian Mediator complex acts as an integrator of transcriptional regulation by RNA Polymerase II, and has emerged as a master coordinator of development and cell fate determination. We previously identified the Mediato…
View article: A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas
A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas Open
Meningiomas are the most common primary intracranial adult tumor. All Neurofibromatosis 2 (NF2)-associated meningiomas and ~60% of sporadic meningiomas show loss of NF2 tumor suppressor protein. There are no effective medical therapies for…