Mariano Cingolani
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View article: Transitioning from conventional to digital methods for estimating time since death: a multi-parameter forensic software
Transitioning from conventional to digital methods for estimating time since death: a multi-parameter forensic software Open
This study introduces a cohesive software solution that integrates traditional and modern methodologies for PMI estimation. The program's comprehensive approach and intuitive design promise to improve accuracy and facilitate broader applic…
View article: Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis
Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis Open
The postmortem diagnosis of anaphylaxis remains a forensic challenge due to the lack of specific external signs. Tryptase, a mast cell‐derived protease, has emerged as a potential biomarker for fatal anaphylaxis. This systematic review cri…
View article: Artificial intelligence in healthcare: transforming patient safety with intelligent systems—A systematic review
Artificial intelligence in healthcare: transforming patient safety with intelligent systems—A systematic review Open
Introduction Adverse events in hospitals significantly compromise patient safety and trust in healthcare systems, with medical errors being a leading cause of death globally. Despite efforts to reduce these errors, reporting remains low, a…
View article: Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective Open
Introduction The evolution of Laboratory Medicine (LM) has expanded diagnostic and therapeutic horizons, yet ethical concerns pervade its advancements. This article explores the ethical challenges inherent in LM and advocates for a persona…
View article: Medico-Legal Applications of the Human Microbiome and Critical Issues Due to Environmental Transfer: A Review
Medico-Legal Applications of the Human Microbiome and Critical Issues Due to Environmental Transfer: A Review Open
Microbiome has recently seen an increase in its forensic applications. It could be employed to identify a suspect when DNA is not available; it can be used to establish postmortem interval (PMI). Furthermore, it could prove to be fundament…
View article: Exogenous Versus Endogenous Nandrolone in Doping Investigations: A Systematic Literature Review
Exogenous Versus Endogenous Nandrolone in Doping Investigations: A Systematic Literature Review Open
Nandrolone, or 19-nortestosterone, is an anabolic steroid derived from testosterone, known for its androgenic and anabolic effects. Often used illicitly by athletes to boost performance, its use is banned by the World Anti-Doping Agency (W…
View article: Disability 4.0: bioethical considerations on the use of embodied artificial intelligence
Disability 4.0: bioethical considerations on the use of embodied artificial intelligence Open
Robotics and artificial intelligence have marked the beginning of a new era in the care and integration of people with disabilities, helping to promote their independence, autonomy and social participation. In this area, bioethical reflect…
View article: Validation of a Headspace Gas Chromatography with Flame Ionization Detection Method to Quantify Blood Alcohol Concentration (BAC) for Forensic Practice
Validation of a Headspace Gas Chromatography with Flame Ionization Detection Method to Quantify Blood Alcohol Concentration (BAC) for Forensic Practice Open
Alcohol consumption is a major social and forensic issue. It is often the cause of road accidents, industrial accidents, suicides and other crimes. On account of this, it is of fundamental importance in forensic toxicology to correctly qua…
View article: New Insights on Molecular Autopsy in Sudden Death: A Systematic Review
New Insights on Molecular Autopsy in Sudden Death: A Systematic Review Open
Sudden unexpected deaths often remain unresolved despite forensic examination, posing challenges for pathologists. Molecular autopsy, through genetic testing, can reveal hidden causes undetectable by standard methods. This review assesses …
View article: Sexually Transmitted Infections in Adolescents and Young Adults: A Cross Section of Public Health
Sexually Transmitted Infections in Adolescents and Young Adults: A Cross Section of Public Health Open
Introduction. Sexually transmitted infections (STIs) can be caused by a number of microorganisms that vary greatly in size, life cycle, clinical manifestations, and sensitivity to available treatments. Transmission of STIs can occur during…
View article: CLINICAL CHALLENGE: AORTITIS IN THE EMERGENCY DEPARTMENT
CLINICAL CHALLENGE: AORTITIS IN THE EMERGENCY DEPARTMENT Open
A 67 yo woman presented to the ED for a sustained episode of palpitations and acute chest pain. Past medical history: suspected psoriatic arthritis previously treated with steroids and hydroxychloroquine; previous suspicion of rheumatic po…
View article: ACUTE MYOCARDIAL INJURY IN A PATIENT WITH TYPE–1 NEUROFIBROMATOSIS: A CASE OF SUSPECTED PHEOCROMOCYTOMA–ASSOCIATED MYOCARDITIS
ACUTE MYOCARDIAL INJURY IN A PATIENT WITH TYPE–1 NEUROFIBROMATOSIS: A CASE OF SUSPECTED PHEOCROMOCYTOMA–ASSOCIATED MYOCARDITIS Open
A 54–year–old patient with an history of type–1 neurofibromatosis presented to the emergency department (ED) due to recurrent abdominal pain with diarrhea. Clinical examination didn’t show anything remarkable. She was mildly hypertensive, …
View article: Editorial: Reproductive medical care in minors: ethical and liability issues
Editorial: Reproductive medical care in minors: ethical and liability issues Open
The proposal for the Research Topic focuses on the study of responsibility and ethical aspects related to health workers involved in assisting minors in their reproductive health. It addresses legal and ethical issues concerning the minors…
View article: Medical ethics questions of COVID-19 vaccination in pregnant and lactating women in East Asia and Oceania.
Medical ethics questions of COVID-19 vaccination in pregnant and lactating women in East Asia and Oceania. Open
We aimed to investigate some of the medical ethics issues that characterize the COVID-19 vaccination phase in pregnancy and breast-feeding. A literature search was conducted using PubMed, Scopus, Web of Science, focusing mainly on the coun…
View article: Liability and Medico-Legal Implications in Estimating the Likelihood of Having Attained 14 Years of Age in Pediatric Clinical Practice: A Pilot Study
Liability and Medico-Legal Implications in Estimating the Likelihood of Having Attained 14 Years of Age in Pediatric Clinical Practice: A Pilot Study Open
Accurate methods of age estimation are more essential than ever due to the rise in undocumented individuals without proper identification, often linked to illegal immigration and criminal activities. This absence of reliable records presen…
View article: Over-the-counter emergency contraception in Italy: ethical reflections and medico-legal issues
Over-the-counter emergency contraception in Italy: ethical reflections and medico-legal issues Open
Although more than ten years have passed since the marketing of Ulipristal acetate in Europe, emergency contraception remains a complex issue with many scientific, legal, ethical and social implications. The topic is an example of the diff…
View article: Operational Health Pavilions in Mass Disasters: Lessons Learned from the 2023 Earthquake in Turkey and Syria
Operational Health Pavilions in Mass Disasters: Lessons Learned from the 2023 Earthquake in Turkey and Syria Open
The massive earthquake that hit Turkey and Syria in February 2023 killed tens of thousands of people, and most of the deceased have not yet been identified. Many victims were pulled from the rubble hours or days later, injured and in need …
View article: Artificial Intelligence in Evaluation of Permanent Impairment: New Operational Frontiers
Artificial Intelligence in Evaluation of Permanent Impairment: New Operational Frontiers Open
Artificial intelligence (AI) and machine learning (ML) span multiple disciplines, including the medico-legal sciences, also with reference to the concept of disease and disability. In this context, the International Classification of Disea…
View article: Detection of Three Opioids (Morphine, Codeine and Methadone) and Their Metabolites (6-Monoacetylmorphine and 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in Larvae of Lucilia sericata Species by UHPLC-TF-MS and Validation
Detection of Three Opioids (Morphine, Codeine and Methadone) and Their Metabolites (6-Monoacetylmorphine and 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in Larvae of Lucilia sericata Species by UHPLC-TF-MS and Validation Open
Insects on corpses could be a useful tool for the detection of exogenous substances such as drugs of abuse. The identification of exogenous substances in carrion insects is critical for proper estimation of the postmortem interval. It also…
View article: Anthropometric analysis of orbital and nasal parameters for sexual dimorphism: New anatomical evidences in the field of personal identification through a retrospective observational study
Anthropometric analysis of orbital and nasal parameters for sexual dimorphism: New anatomical evidences in the field of personal identification through a retrospective observational study Open
Orbital and nasal parameters among modern humans show considerable variation, which affects facial shape, and these characteristics vary according to race, region, and period in evolution. The aim of the study was to ascertain whether ther…
View article: C1 COMPLETE HEART BLOCK AS A RARE MANIFESTATION OF GRANULOMATOSIS WITH POLYANGITIS: A CASE REPORT
C1 COMPLETE HEART BLOCK AS A RARE MANIFESTATION OF GRANULOMATOSIS WITH POLYANGITIS: A CASE REPORT Open
A 42–year–old male with prior smoking habit presented at our emergency department after atraumatic syncope preceded by severe pain in the left lower limb. One month prior to presentation, due to persistence of nonproductive cough he underw…
View article: Leading Pathogens Involved in Co-Infection and Super-Infection with COVID-19: Forensic Medicine Considerations after a Systematic Review and Meta-Analysis
Leading Pathogens Involved in Co-Infection and Super-Infection with COVID-19: Forensic Medicine Considerations after a Systematic Review and Meta-Analysis Open
The COVID-19 pandemic raised concerns about the potential for co-infection or over-infection with other respiratory infections, as they can complicate the diagnosis, treatment and prognosis of the disease. This is also a challenge for fore…
View article: What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant?
What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant? Open
Pulmonary damage in SARS-CoV-2 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis. In addition, nosocomial bacterial superinfections and ventilator-induced lung injury (VILI) are likely to occur. The SARS-CoV-2…
View article: The State of Play on COVID-19 Vaccination in Pregnant and Breastfeeding Women: Recommendations, Legal Protection, Ethical Issues and Controversies in Italy
The State of Play on COVID-19 Vaccination in Pregnant and Breastfeeding Women: Recommendations, Legal Protection, Ethical Issues and Controversies in Italy Open
To date, extensive research has been conducted on vaccination against COVID-19 during pregnancy to verify the safety and efficacy of the vaccines, despite the fact that pregnant women were excluded from the initial clinical trials. The eve…