Mariano Colón-Caraballo
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View article: Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression
Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression Open
Progesterone (P4), acting via its nuclear receptor (PR), is critical for pregnancy maintenance by suppressing proinflammatory and contraction-associated protein (CAP)/contractile genes in the myometrium. P4/PR partial…
View article: RETRACTED: Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy
RETRACTED: Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy Open
View article: Human Endometriosis Tissue Microarray Reveals Site-specific Expression of Estrogen Receptors, Progesterone Receptor, and Ki67
Human Endometriosis Tissue Microarray Reveals Site-specific Expression of Estrogen Receptors, Progesterone Receptor, and Ki67 Open
Most available therapies for endometriosis are hormone-based and generally broadly used without taking into consideration the ovarian hormone receptor expression status. This contrasts strikingly with the standard of care for other hormone…
View article: Effects of histone methyltransferase inhibition in endometriosis†
Effects of histone methyltransferase inhibition in endometriosis† Open
Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. We have previously reported that endometriotic lesions…
View article: Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion†
Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion† Open
High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, reported to be elevated in …
View article: Elucidating the Expression Profile of EZH2 Isoforms in Endometriosis: An immunohistochemical study
Elucidating the Expression Profile of EZH2 Isoforms in Endometriosis: An immunohistochemical study Open
Endometriosis is an estrogen-dependent gynecological disease that affects 1 out of 10 women of reproductive age causing severe pelvic pain and infertility. Factors including genetics, environment, inflammation, and recently epigenetics hav…
View article: H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis
H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis Open