Mariavittoria Pizzinga
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View article: Phosphorylation of the Smooth Muscle Master Splicing Regulator RBPMS Regulates its Splicing Activity
Phosphorylation of the Smooth Muscle Master Splicing Regulator RBPMS Regulates its Splicing Activity Open
We previously identified RBPMS as a master regulator of alternative splicing in differentiated smooth muscle cells (SMCs). RBPMS is transcriptionally downregulated during SMC dedifferentiation, but we hypothesized that RBPMS protein activi…
View article: A system-wide quantitative map of RNA and protein subcellular localisation dynamics
A system-wide quantitative map of RNA and protein subcellular localisation dynamics Open
Existing methods to analyse RNA localisation are constrained to specific RNAs or subcellular niches, precluding the cell-wide mapping of RNA. We present Localisation of RNA (LoRNA), which maps, at once, RNAs to membranous (nucleus, ER and …
View article: Don’t shoot the messenger… shoot the reader
Don’t shoot the messenger… shoot the reader Open
View article: Author Correction: Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)
Author Correction: Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS) Open
View article: Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)
Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS) Open
View article: Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth
Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth Open
mRNA localization serves key functions in localized protein production making it critical that the translation machinery itself is present at these locations. Here we show that translation factor mRNAs are localized to distinct granules wi…
View article: Unbiased dynamic characterization of RNA-protein interactions by OOPS
Unbiased dynamic characterization of RNA-protein interactions by OOPS Open
Current methods for the identification of RNA–protein interactions require a quantity and quality of sample that hinders their application, especially for dynamic biological systems or when sample material is limiting. Here, we present a n…
View article: Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins
Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins Open
The ability of mammalian cells to modulate global protein synthesis in response to cellular stress is essential for cell survival. While control of protein synthesis is mediated by the regulation of eukaryotic initiation and elongation fac…
View article: Till stress do us ataRT: a novel toxin–antitoxin system targeting translation initiation
Till stress do us ataRT: a novel toxin–antitoxin system targeting translation initiation Open